Antibacterial prophylaxis with lactoferrin in neutropenic patients

Trümpler, U.; Straub, P W; Rosenmund, A

doi:10.1007/bf01963459

Cited by 47 publications

(16 citation statements)

References 14 publications

(6 reference statements)

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“…2006). Several studies have revealed anti‐inflammatory, antibacterial, and protective properties of LF (Trumpler et al. 1989; Lonnerdal & Iyer 1995; Shimazaki et al.…”

Section: Discussionmentioning

confidence: 99%

Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide‐injected preruminant calves

Kushibiki

Shingu

Komatsu

et al. 2009

Animal Science Journal

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The aim of this study was to investigate the influence of oral lactoferrin (LF) administration on lipid metabolism changes in calves given lipopolysaccharide (LPS). Twenty-one 4-day-old Holstein calves were divided into three groups, with each group receiving one of three oral doses of LF (0, 1, 3 g/day) for 10 consecutive days (day -10 to day -1). All calves were intravenously injected with LPS (50 ng/kg BW) on day 0, the day after LF treatment ended. Plasma triglyceride concentrations were lower (P < 0.05) in the LF-treated calves than in the control calves given 0 g/day of LF at 12 and 24 h after LPS injection. Plasma NEFA concentrations were elevated between 6 and 24 h after LPS treatment. At 12 h, the concentration of plasma NEFA was lower (P < 0.05) in the calves given LF 3 g/day than in the control calves. On day 0, plasma total cholesterol and phospholipid concentrations tended to be lower in the LF groups administered 1 and 3 g of LF/day than in the control group, but did not differ significantly among the groups. The plasma very-low-density and low-density lipoprotein concentrations were lower (P < 0.05) at 12, 24, and 72 h in the LF groups than in the control calves. The concentrations of plasma high-density lipoprotein tended to be lower in the LF groups than in the control group between day 0 and 96 h, though there were no significant group differences. The concentration of plasma interleukin-1beta was lower (P < 0.05) in the calves fed LF 3 g/day than in the control calves at 2 and 12-48 h after LPS injection. These data suggest that LF inhibits LPS-induced alterations in lipid metabolism in preruminant calves.

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“…2006). Several studies have revealed anti‐inflammatory, antibacterial, and protective properties of LF (Trumpler et al. 1989; Lonnerdal & Iyer 1995; Shimazaki et al.…”

Section: Discussionmentioning

confidence: 99%

Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide‐injected preruminant calves

Kushibiki

Shingu

Komatsu

et al. 2009

Animal Science Journal

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“…It is highly suggestive that lactoferrin may be active at the infection site as well. Trumpler et al 32 clinically confirmed the effectivity of lactoferrin in alleviating the course of infection in in patients with neutropenia to whom chemotherapy was applied.…”

Section: General Lactoferrin Propertiesmentioning

confidence: 85%

Therapeutic properties of lactoferrin

Dzik¹,

Olsztyn²,

Miciński³

et al. 2018

Pol. Ann. Med.

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“…The authors concluded the GMP prevention of oral bacterial adhesion to polystyrene tubes took place with no species specificity and could be compared to nonspecific inhibition exhibited by various polymers. In a model of arterial thrombosis, triggered by laser-induced intimal injury in the guinea pig, GMP, the undecapeptide [residues [106][107][108][109][110][111][112][113][114][115][116] and the pentapeptide [residues [112][113][114][115][116], exerted a significant antithrombotic activity [149]. That activity was achieved in vivo for doses less than one could predict from in vitro results.…”

Section: Caseinsmentioning

confidence: 96%

“…The ability of Lf to bind free iron could be of significance to control the physiological balance between reactive oxygen species [ROS] production and the rate of their elimination, which naturally protects against oxidative stress cell injury [109]. Oxidative stress has been implicated in a variety of pathological and chronic degenerative processes including the development of cancer, atherosclerosis, inflammation, aging, neurodegenerative disorders and also in defense against infection [110][111][112].…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

Molecular and Biotechnological Advances in Milk Proteins in Relation to Human Health

Kanwar¹,

Kanwar²,

Sun³

et al. 2009

CPPS

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Milk and colostrum is a rich source of proteins/peptides which have crucial roles in both neonates and adults. Milk bioactive proteins and peptides are potential health-enhancing nutraceuticals for food. Many bioactive peptides/proteins may be used as nutraceuticals, for example, in the treatment of cancer, asthma, diarrhea, hypertension, thrombosis, dental diseases, as well as mineral malabsorption, and immunodeficiency. The following components of milk are of particular interest in the recent years: 1) Lactoferrin [Lf] has antibacterial, antifungal, antiviral, antiparasite and antitumor activities and accelerates immunomodulatory properties. Lf is a potent inhibitor for several enveloped and naked viruses, such as rotavirus, enterovirus and adenovirus. Lf is resistant to tryptic digestion and breast-fed infants excrete high levels of faecal Lf, so that its effect on viruses replicating in the gastrointestinal tract is of great interest. 2) Casein has been protective in experimental bacteremia by eliciting myelopoiesis. Casein hydrolyzates were also protective in diabetic animals, reduced the tumor growth and diminished colicky symptoms in infants. 3) A Proline rich polypeptide [PRP] revealed variety of immunotropic functions, including promotion of T-cell activation and inhibition of autoimmune disorders such as multiple sclerosis. 4) alpha-Lactalbumin [LA] demonstrates antiviral, antitumor and anti-stress properties. 5) Lactoperoxidase shows antibacterial properties. 6) Lysozyme is effective in treatment of periodentitis and prevention of tooth decay. Taken together, milk-derived proteins and peptides are bio-available and safe for the prevention and treatment of various disorders in humans and may play a complementary [natural agents] rather than a substitutional role to the toxic synthetic pharmacological drugs.

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Antibacterial prophylaxis with lactoferrin in neutropenic patients

Cited by 47 publications

References 14 publications

Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide‐injected preruminant calves

Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide‐injected preruminant calves

Therapeutic properties of lactoferrin

Molecular and Biotechnological Advances in Milk Proteins in Relation to Human Health

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