Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide‐injected preruminant calves

Abstract

The aim of this study was to investigate the influence of oral lactoferrin (LF) administration on lipid metabolism changes in calves given lipopolysaccharide (LPS). Twenty-one 4-day-old Holstein calves were divided into three groups, with each group receiving one of three oral doses of LF (0, 1, 3 g/day) for 10 consecutive days (day -10 to day -1). All calves were intravenously injected with LPS (50 ng/kg BW) on day 0, the day after LF treatment ended. Plasma triglyceride concentrations were lower (P < 0.05) in the LF-treated calves than in the control calves given 0 g/day of LF at 12 and 24 h after LPS injection. Plasma NEFA concentrations were elevated between 6 and 24 h after LPS treatment. At 12 h, the concentration of plasma NEFA was lower (P < 0.05) in the calves given LF 3 g/day than in the control calves. On day 0, plasma total cholesterol and phospholipid concentrations tended to be lower in the LF groups administered 1 and 3 g of LF/day than in the control group, but did not differ significantly among the groups. The plasma very-low-density and low-density lipoprotein concentrations were lower (P < 0.05) at 12, 24, and 72 h in the LF groups than in the control calves. The concentrations of plasma high-density lipoprotein tended to be lower in the LF groups than in the control group between day 0 and 96 h, though there were no significant group differences. The concentration of plasma interleukin-1beta was lower (P < 0.05) in the calves fed LF 3 g/day than in the control calves at 2 and 12-48 h after LPS injection. These data suggest that LF inhibits LPS-induced alterations in lipid metabolism in preruminant calves.

Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice

“…In accord with previous studies [36], [37], we observed that the non-esterified fatty acid levels decreased significantly in the LF-treated group. Triglyceride levels showed a similar tendency, although no marked differences could be found.…”

Comparison of immune response to lipopolysaccharide of rabbit does selected for litter size at weaning or founded for reproductive longevity

“…LPS induction usually drives the liver to a total depletion of hepatocyte glycogen. This, together with the concomitant lack of feed consumption, might lead to the pronounced hypoglycemia (Ferrante et al, 1984;Fukuzumi et al, 1996;Leininger et al, 2000) and NEFA mobilization (Webel et al, 1997;Leininger et al, 2000;Kushibiki et al, 2009), commonly observed after LPS challenges in other species.…”

Peptides from Natural or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies

“…Bovine lactoferrin was found to produce beneficial effects on plasma lipid concentrations. Its administration in rodents led to increased plasma high-density lipoprotein (HDL) cholesterol concentrations, decreased plasma concentrations of triacylglycerol and non-esterified fatty acids, and decreased hepatic cholesterol and triacylglycerol concentrations [257][258][259][260][261][262]. Lactoferrin is also produced by neutrophils, and some human studies showed its plasma levels are negatively associated with overall adiposity and an altered glucose tolerance [263,264].…”