Antibacterial Property and Cytotoxicity of a Poly(lactic acid)/Nanosilver-Doped Multiwall Carbon Nanotube Nanocomposite

Abstract

A novel method was used to synthesize a nanosilver-doped multiwall carbon nanotube (MWCNT-Ag), and subsequently, the novel poly(lactic acid) (PLA)-and MWCNT-Ag-based biocompatible and antimicrobial nanocomposites were prepared by melt blending. Based on energy dispersive X-ray spectrometry images, an MWCNT-Ag was successfully synthesized. The effect of the MWCNT-Ag on the PLA bionanocomposites was investigated by evaluating their thermal and mechanical properties, antifungal activity, and cytotoxicity. The nanocomposites exhibited a high degree of biocompatibility with the MWCNT-Ag content, which was less than 0.3 phr. Furthermore, tensile strength testing, thermogravimetric analysis, differential scanning calorimetry, and antibacterial evaluation revealed that the tensile strength, thermostability, glass transition temperature, and antibacterial properties were enhanced by increasing the MWCNT-Ag content. Finally, hydrolysis analysis indicated that the low MWCNT-Ag content could increase the packing density of PLA.

Development of Antimicrobial Packaging Film Made from Poly(Lactic Acid) Incorporating Titanium Dioxide and Silver Nanoparticles

“…The nano-TiO 2 could kill microbes because its particle size is very small, and it would generated many electron–hole pairs, which induced redox reactions on those microorganisms [ 49 ]. The antimicrobial mechanism of nano-Ag is that the nano-Ag particle might accumulate in the bacterial cytoplasmic membrane, and the membrane permeability of the bacteria increased significantly, which led to cell death [ 37 , 50 ].…”

Effect of multiscale structure on the gas barrier properties of poly(lactic acid)/Ag nanocomposite films

“…In this concern, the high thermostability of inorganic antimicrobial agents such as metallic nanoscale materials could be incorporated into the food packaging system to extend the shelf life of food and maintain food safety and quality . If the packaging film provides barrier properties to small molecules such as water, CO 2 , and O 2 , they can effectively control the deterioration of agricultural products . One of the most common metallic nanoparticles used in the food packaging industry is nano‐Ag …”

“…2,9,10 If the packaging film provides barrier properties to small molecules such as water, CO 2 , and O 2 , they can effectively control the deterioration of agricultural products. 11,12 One of the most common metallic nanoparticles used in the food packaging industry is nano-Ag. [13][14][15][16][17] The PLA/nano-Ag composites had been reported to give improvements in barrier properties.…”

Preparation and characterization of poly(lactic acid) with adipate ester added as a plasticizer

“…Lai and Li 21 modified silica by melt blending it with polyurethane to initiate the nucleation of PLA; the crystallization peak temperature and optical transmittance of the modified silica/PLA composite were higher than those of the unmodified silica/PLA composite. Tsou et al 22 synthesized a new nanomaterial (nanosilver-doped multiwall carbon nanotube) to enhance the mechanical property, theromostability, and antibacterial properties of PLA. Moreover, Tsou et al 18 indicated that acetyl tributyl citrate as a plasticizer could enhance the elongation at break of PLA/tapioca composites.…”