Antibacterial properties of Ya-Samarn-Phlae (YaSP): A pilot study on diabetic patients with chronic ulcers

Sanpinit, Sineenart; Yincharoen, Kanyatorn; Jindamanee, Chadaporn; Jobthin, Suwit; Limsuwan, Surasak; Kunworarath, Nongluk; Jaisamut, Patcharawalai; Chokpaisarn, Julalak; Voravuthikunchai, Supayang Piyawan; Chusri, Sasitorn

doi:10.1016/j.hermed.2020.100381

Cited by 7 publications

(5 citation statements)

References 25 publications

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“… Azadirachta indica, Moringa pterygosperma, Eclipta alba, Boerhaavia diffusa, Carumcopticum, Terminalia chebula, Terminalia belerica, Emblica officinalis, Santalum album, Ocimum sanctum, Vitex negundo, Curcuma longa, Mentha piperata, Cinnamomum camphora, Amomum subulatum, Rosa centifolia, Rock salt, Pearl, Honey Itone™ Wistar albino rats Anti-inflammatory activity by reduction of LTB4 formation [ 54 ] Theme 3: Polyherbal formulations against infections aiding wound healing 49. Garcinia mangostana , Oryza sativa , Curcuma longa , and Areca catechu – Human (Diabetic foot ulcers) Antibacterial activity against Staphylococcus epidermidis and Pseudomonas aeruginosa [ 55 ] 50. Acacia catechu (heart wood), Lagerstroemia speciosa (Leaves), Aegle marmelos (fruits), Phyllanthus emblica (fruits) and Terminalia chebula (fruits) Polyherbal Gel Human vaginal keratinocyte cell line Anti-HIV-1 activity and also effective in healing vaginal wounds caused by Lactobacillus infection [ 56 ] 51.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore the current review has analyzed studies associated with evaluatiing the antimicrobial potentials of various wound care polyherbal formulations. In this context, it was observed that polyherbal formulations are effective against a good range of gram-positive bacteria, gram-negative bacteria, and fungi that are often associated with wound infection [ 55 ]. Some formulations are also derived for combating infections in areas prone to infectious wounds such as the vagina [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some formulations are also derived for combating infections in areas prone to infectious wounds such as the vagina [ 56 ]. Many studies have mentioned that the antimicrobial nature of polyherbal formulations is also attributed to the phenol and flavonoid contents of the herbs [ 55 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

Dubey¹,

Dixit²

2023

Journal of Ayurveda and Integrative Medicine

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

Dubey¹,

Dixit²

2023

Journal of Ayurveda and Integrative Medicine

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“…Sanpinit et al's investigation meant to study the antibacterial, antibioflm, and woundhealing impacts of pericarp extracts of G. mangostana as a constituent of Ya-Samarn-Phlae (YaSP) oil, a traditional Tai polyherbal preparation, against infective bacteria in DFUs. Treatment using YaSP oil bandage on 14 DM2 patients for four weeks showed improvement of ulcers of varying degrees and antibacterial activity; G. mangostana has signifcant antibacterial efects against Staphylococcus [73].…”

Section: Renal Failure and Oxidative Stressmentioning

confidence: 94%

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Safaei,

Sakhaee,

Saberifar

et al. 2023

Journal of Food Biochemistry

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Diabetes mellitus is one of the leading public health problems, affecting about 10% of the population. Chronic complications of diabetes cause several human sufferings, including kidney failure, blindness, amputations, stroke, and myocardial infarction. Xanthones from mangosteen fruit (Garcinia mangostana) and their physiological effects, such as antiobesity, antihyperglycemic, antidyslipidemia, antidiabetic, and anti-inflammatory effects have been demonstrated in experimental studies to have beneficial effects on obesity, diabetes, hyperglycemic, dyslipidemia, and inflammatory states. It is worthwhile to mention that, in this context, the PubMed, Scopus, and Google Scholar databases have been searched for articles containing the keywords of “Garcinia mangostana,” “Mangosteen,” “α-mangostin,” “diabetes mellitus,” “diabetes complication,” “hypoglycemic,” “antihyperglycemic,” “antidiabetic,” and “without publication time limitation”. This study aims to review the in silico, in vitro, in vivo, and clinical pharmacological effects of mangosteen fruit and its xanthones on diabetes mellitus and its complications as well as their molecular pathways related to them. Taking into account the findings of these studies, we can say that mangosteen fruit and its xanthones hold significant potential for designing human studies for controlling and even modifying diabetes mellitus and its related diseases.

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“…Unfortunately, there have been few studies that focused on the treatment of biofilm-associated DFUs. A search on SCOPUS (2021) with the words: “Antibiofilm diabetic foot ulcer” in the title, keywords and abstract only displayed eleven research items: three reviews [ 118 , 162 , 163 ]; seven research articles about new antibiofilm approaches [ 164 , 165 , 166 , 167 , 168 , 169 , 170 ]; and one about the design of antibiofilm peptides [ 171 ]. Thus, in this review, the most promising molecules and techniques to combat biofilm formation or to disaggregate already established mature biofilms, and that can be used in the prevention/control of biofilm-associated DFU infections, will be summarised ( Table S1 ).…”

Section: The Role Of Biofilms In Diabetic Foot Ulcersmentioning

confidence: 99%

Biofilms in Diabetic Foot Ulcers: Impact, Risk Factors and Control Strategies

Afonso

Oliveira

Saavedra

et al. 2021

IJMS

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Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients’ life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. In fact, appropriate treatment for the elimination of these microbial communities can prevent the disease evolution and, in some cases, even avoid more serious outcomes, such as amputation or death. However, the detection of biofilm-associated DFUs is difficult due to the lack of methods for diagnostics in clinical settings. In this review, the current knowledge on the involvement of biofilms in DFUs is discussed, as well as how the surrounding environment influences biofilm formation and regulation, along with its clinical implications. A special focus is also given to biofilm-associated DFU diagnosis and therapeutic strategies. An overview on promising alternative therapeutics is provided and an algorithm considering biofilm detection and treatment is proposed.

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Antibacterial properties of Ya-Samarn-Phlae (YaSP): A pilot study on diabetic patients with chronic ulcers

Cited by 7 publications

References 25 publications

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Biofilms in Diabetic Foot Ulcers: Impact, Risk Factors and Control Strategies

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