Antibacterial properties of silver nanoparticles grown in situ and anchored to titanium dioxide nanotubes on titanium implant against Staphylococcus aureus

Gunputh, Urvashi; Le, Huirong; Lawton, Kiruthika; Besinis, Alexandros; Tredwin, Christopher; Handy, Richard D.

doi:10.1080/17435390.2019.1665727

Cited by 65 publications

(45 citation statements)

References 38 publications

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“…37 Modifying implant surfaces with silver nanoparticles, using various doped methods, is currently an area of intensive interest, due to the safety and strong antibacterial properties of silver nanoparticles. 38 Researchers have demonstrated the long-term antibacterial effect of titanium implants coated with silver nanoparticles by steadily controlling silver ion release with various coating methods. 39 The antibacterial effect can also be prolonged by immobilizing silver nanoparticles on implant surfaces.…”

Section: Dental Implant Treatmentmentioning

confidence: 99%

The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

1,074

681

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Nanotechnology has recently emerged as a rapidly growing field with numerous biomedical science applications. At the same time, silver has been adopted as an antimicrobial material and disinfectant that is relatively free of adverse effects. Silver nanoparticles possess a broad spectrum of antibacterial, antifungal and antiviral properties. Silver nanoparticles have the ability to penetrate bacterial cell walls, changing the structure of cell membranes and even resulting in cell death. Their efficacy is due not only to their nanoscale size but also to their large ratio of surface area to volume. They can increase the permeability of cell membranes, produce reactive oxygen species, and interrupt replication of deoxyribonucleic acid by releasing silver ions. Researchers have studied silver nanoparticles as antimicrobial agents in dentistry. For instance, silver nanoparticles can be incorporated into acrylic resins for fabrication of removable dentures in prosthetic treatment, composite resin in restorative treatment, irrigating solution and obturation material in endodontic treatment, adhesive materials in orthodontic treatment, membrane for guided tissue regeneration in periodontal treatment, and titanium coating in dental implant treatment. Although not all authorities have acknowledged the safety of silver nanoparticles, no systemic toxicity of ingested silver nanoparticles has been reported. A broad concern is their potential hazard if they are released into the environment. However, the interaction of nanoparticles with toxic materials and organic compounds can either increase or reduce their toxicity. This paper provides an overview of the antibacterial use of silver nanoparticles in dentistry, highlighting their antibacterial mechanism, potential applications and safety in clinical treatment.

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Section: Dental Implant Treatmentmentioning

confidence: 99%

The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

1,074

681

View full text Add to dashboard Cite

show abstract

“…19 Therefore, it is essential to look for new antibacterial substances (new generation of antibacterial drugs) to prevent the growth of bacteria. Silver, 20,21 gold 22,23 and platinum 24,25 nanoparticles (NPs) exhibit significant antibacterial activity. This property is due to the extremely small size and surface-tovolume ratio of these particles.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches

Arsalan

Kashi

Hasan

et al. 2020

IJN

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The interaction of NPs with biological systems may reveal useful details about their pharmacodynamic, anticancer and antibacterial effects. Methods: Herein, the interaction of as-synthesized Co 3 O 4 NPs with HSA was explored by different kinds of fluorescence and CD spectroscopic methods, as well as molecular docking studies. Also, the anticancer effect of Co 3 O 4 NPs against leukemia K562 cells was investigated by MTT, LDH, caspase, real-time PCR, ROS, cell cycle, and apoptosis assays. Afterwards, the antibacterial effects of Co 3 O 4 NPs against three pathogenic bacteria were disclosed by antibacterial assays. Results: Different characterization methods such as TEM, DLS, zeta potential and XRD studies proved that fabricated Co 3 O 4 NPs by sol-gel method have a diameter of around 50 nm, hydrodynamic radius of 177 nm with a charge distribution of −33.04 mV and a welldefined crystalline phase. Intrinsic, extrinsic, and synchronous fluorescence as well as CD studies, respectively, showed that the HSA undergoes some fluorescence quenching, minor conformational changes, microenvironmental changes as well as no structural changes in the secondary structure, after interaction with Co 3 O 4 NPs. Molecular docking results also verified that the spherical clusters with a dimension of 1.5 nm exhibit the most binding energy with HSA molecules. Anticancer assays demonstrated that Co 3 O 4 NPs can selectively lead to the reduction of K562 cell viability through the cell membrane damage, activation of caspase-9,-8 and-3, elevation of Bax/Bcl-2 mRNA ratio, ROS production, cell cycle arrest, and apoptosis. Finally, antibacterial assays disclosed that Co 3 O 4 NPs can stimulate a promising antibacterial effect against pathogenic bacteria. Conclusion: In general, these observations can provide useful information for the early stages of nanomaterial applications in therapeutic platforms.

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“…AgNPs are able to penetrate into bacterial cell walls, change the structure of cell membranes and even result in cell death, with the antibacterial mechanisms of contact killing and ion-mediated killing [126]. TiO 2 -NTs decorated with AgNPs exhibited antibacterial properties against S. aureus and showed better biocompatibility with human cells after obtaining a nanoform of HA top coating [127]. Recent studies confirmed that the coating of PDA and AgNPs on the surface of titanium could effectively inhibit the microbial growth against S. mutans and P. gingivalis [128,129].…”

Section: The Antimicrobial Properties Of Metal Element Componentsmentioning

confidence: 99%

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

et al. 2020

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Dental implants are widely used in the field of oral restoration, but there are still problems leading to implant failures in clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict the success rate of dental implants and patient satisfaction. Poor osseointegration and bacterial infection are the most essential reasons resulting in implant failure. To improve the clinical outcomes of implants, many scholars devoted to modifying the surface of implants, especially to preparing different physical and chemical modifications to improve the osseointegration between alveolar bone and implant surface. Besides, the bioactive-coatings to promote the adhesion and colonization of ossteointegration-related proteins and cells also aim to improve the osseointegration. Meanwhile, improving the anti-bacterial performance of the implant surface can obstruct the adhesion and activity of bacteria, avoiding the occurrence of inflammation related to implants. Therefore, this review comprehensively investigates and summarizes the modifying or coating methods of implant surfaces, and analyzes the ossteointegration ability and anti-bacterial characteristics of emerging functional coatings in published references.

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Antibacterial properties of silver nanoparticles grown in situ and anchored to titanium dioxide nanotubes on titanium implant against Staphylococcus aureus

Abstract: Antibacterial properties of silver nanoparticles grown in situ and anchored to titanium dioxide nanotubes on titanium implant against Staphylococcus aureusGunputh, UF

Cited by 65 publications

References 38 publications

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

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