Antibacterial properties of lidocaine on bacteria isolated from dermal lesions

Antibacterial Activity of Preservative-Free Topical Anesthetic Drops in Current Use in Ophthalmology Departments

“…Variables such as the amount of anesthetic in the conjunctival sac, the tear volume, the number of organisms in the ulcer, and the time of exposure to the drug may all cause a variation on the overall effect of the anesthetic. 10 The MICs found in this study ranged from 625 to 5000 mg/mL, the lowest were obtained with tetracaine and the highest with proxymetacaine. The MICs corresponded to a number of dilutions ranging from 1:2 with proxymetacaine to 1:16 with tetracaine.…”

“…Previous literature confirms that different bacterial strains may have different susceptibility to drugs; therefore, more comparative data are necessary about more bacterial and fungal strains. 10 To draw conclusions on the in vivo effect of drugs applied to the human cornea, additional factors need consideration. Variables such as the amount of anesthetic in the conjunctival sac, the tear volume, the number of organisms in the ulcer, and the time of exposure to the drug may all cause a variation on the overall effect of the anesthetic.…”

Safety of Liposuction Using Exclusively Tumescent Local Anesthesia in 3,240 Consecutive Cases

“…The compression garments enhance this drainage. Third, there is a possible antibacterial effect of lidocaine, [18][19][20] and it has been suggested that the presence of sodium bicarbonate in the tumescent solution could enhance the antibacterial 21 although others believe that the solution used in TLA does not significantly inhibit the growth of commonly encountered bacteria. 22 Fourth, because the only entries are the incision sites, and open surgery is not involved, the risk of contamination by the surroundings is reduced.…”

Does Use of Lidocaine Affect Culture of Synovial Fluid Obtained to Diagnose Periprosthetic Joint Infection (PJI)? An In Vitro Study

“…Lidocaine is a local anesthetic agent with known antibacterial activity [ 19 , 22 – 24 ]. Miller et al [ 14 ] reported that bacteriologic investigation of samples taken during dermal and subdermal minor surgical interventions can lead to false-negative results when lidocaine is used for these procedures. Stratford et al [ 25 ] found a 70% decrease in bacterial density when lidocaine injected in infiltrative form was inoculated into the area.…”

“…As a local anesthetic, lidocaine is already used before the procedure of arthrocentesis. Based on reports on the properties of lidocaine against some bacteria in vivo and in vitro , its use in microbiological sampling can pose a problem by causing false-negative results [ 14 – 17 ]. Based on the literature, we hypothesized that the results of SFC are adversely affected by use of lidocaine for local anesthesia.…”