Antibacterial properties of laser spinning glass nanofibers

Echezarreta-Lopez, M.; Miguel, Trinidad de; Quintero, F.; Pou, J.; Landín, Mariana

doi:10.1016/j.ijpharm.2014.09.050

Cited by 13 publications

(8 citation statements)

References 37 publications

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“…The correspondent assignments for sharp peaks formed after the later heat treatments (T c2 and T c3 ) are presented in Figure 3d, from where vibrational peaks ranging from 636 to 595 and 1270−1010 cm −1 can be attributed to the formation of Si−O−Si bonds and Si−O−Si asymmetric stretching, respectively. 37,39,42 On the other hand, peaks ranging from 735 to 680 and 1010−935 cm −1 can be assigned to bending of B 2 −O bonds in the borate glassy network and B 2 − O bond of tetrahedral [BO 4 ]. 36,43,44 Finally, peaks ranging from 680 to 645 and 1195−1010 cm −1 can be attributed to the formation of Si−O−B bonds.…”

Section: Resultsmentioning

confidence: 99%

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Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Fernandes

Gentile

Moorehead

et al. 2016

Crystal Growth & Design

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1Three novel borosilicate bioactive glasses (BBGs) of general formula of 0.05Na2O0.35x 2 0.20B2O30.40SiO2 (molar ratio, where x = MgO or CaO or SrO) were prepared and used to 3 investigate the effect of crystallisation on their properties including cytotoxicity. The three post-4 melt compositions were determined using X-ray fluorescence spectroscopy and crystallisation 5 events were studied using differential thermal analysis and x-ray diffraction. This information was 6 used to determine heat treatments to prepare glass-ceramics by controlled crystallisation. X-ray 7 diffraction analysis and Fourier transform infrared spectroscopy showed that, after higher heat 8 treatment temperatures (800-900 ºC), borosilicate bioactive glass-ceramics (BBGCs) contained 9 mainly borate and silicate crystalline phases. Specifically, BBG-Mg, BBG-Ca and BBG-Sr glass-10 ceramics detected the presence of magnesium silicate-Mg2(SiO3)2 and magnesium borate-Mg2B2O5; 11 wollastonite-2M-CaSiO3 and calcium borate-Ca(BO2)2; and strontium silicate-SrSiO3 and strontium 12 borate-Sr2B2O5, respectively. In vitro cytotoxicity tests were performed using the mouse fibroblast 13 cell line (L929). Glass and glass ceramic at concentrations lower than 50 mg/ml did not exhibit any 14 level of cytotoxicity when compared with the control. However, quantitative evaluation indicated 15 that greater cell growth occurred in the presence of materials with crystalline phases. Control of 16BBGs crystallisation may therefore be used to influence the biocompatibility of these glass-ceramic 17 systems. 18

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Section: Resultsmentioning

confidence: 99%

“…ATR-7 FTIR spectra of all BBGs consist of dominant broad bands from 740-585 and 1210-740 cm stretching, respectively [37][38][39] . The presence of these intense bands indicates the coexistence of 12 silicate and borate bonds, which supports the presence of borosilicate network structure in the 13 amorphous phase.…”

Section: Differential Thermal Analysis 12mentioning

confidence: 99%

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Fernandes

Gentile

Moorehead

et al. 2016

Crystal Growth & Design

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“…TEM micrographs of ICIE16M nanofibers ( Figure 10) do not show the mechanical or physical effect of nanofibers on the bacteria which has been demonstrated for other nanofibers compositions. 61 The increase in the effectiveness against S aureus after the third day of culture ( Figure 5) can be attributed to the toxic effect of Zn and Sr ions on bacterial biological mechanisms for the 75 mg/mL concentration. At this concentration, some cell walls ( Figure 10) seem damaged after 4 days of culture, suggesting a toxic effect derived from physicochemical changes in bacterial environment, pH or potential interfacial variations promoted by the presence of the doped nanofibers.…”

Section: Discussionmentioning

confidence: 97%

Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

et al. 2016

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The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.

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“…Bioactive glasses are used for numerous applications, such as middle ear small bone replacement, cochlear implants, endosseous ridge maintenance implants, jaw bone defects fillers… [22]. They present a composition based on SiO 2 , CaO, P 2 O, and NaO which, in addition to being essential to guarantee the regeneration of tissues, endows them with antibacterial properties [23,24]. Ion release obtained during their resorption activates cell differentiation by the activation of specific genes [27], and also has devastating effects for some bacterial species [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…They present a composition based on SiO 2 , CaO, P 2 O, and NaO which, in addition to being essential to guarantee the regeneration of tissues, endows them with antibacterial properties [23,24]. Ion release obtained during their resorption activates cell differentiation by the activation of specific genes [27], and also has devastating effects for some bacterial species [23,24]. The ability of bioactive glasses to form a hydroxycarbonate apatite layer in aqueous media is not only used to design and develop scaffolds for tissue engineering, but also to protect enamel during tooth bleaching treatment [28].…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Biomimetic Ceramics for Tissue Engineering

Díaz‐Rodríguez

Sánchez

2018

Pharmaceutics

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The mimesis of biological systems has been demonstrated to be an adequate approach to obtain tissue engineering scaffolds able to promote cell attachment, proliferation, and differentiation abilities similar to those of autologous tissues. Bioceramics are commonly used for this purpose due to their similarities to the mineral component of hard tissues as bone. Furthermore, biomimetic scaffolds are frequently loaded with diverse therapeutic molecules to enhance their biological performance, leading to final products with advanced functionalities. In this review, we aim to describe the already developed bioceramic-based biomimetic systems for drug loading and local controlled release. We will discuss the mechanisms used for the inclusion of therapeutic molecules on the designed systems, paying special attention to the identification of critical parameters that modulate drug loading and release kinetics on these scaffolds.

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Antibacterial properties of laser spinning glass nanofibers

Cited by 13 publications

References 37 publications

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

Drug-Loaded Biomimetic Ceramics for Tissue Engineering

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