Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Xu, Yunling; Wang, Yuji; He, Jiaolong; Zhu, Wanpeng

doi:10.3389/fmicb.2022.947102

Cited by 14 publications

(12 citation statements)

References 46 publications

(47 reference statements)

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“…According to a study by Beshay M. et al, the presence of contusion was found to be associated with mortality (9).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Trauma Patients Admitted to a Tertiary Care University Hospital Emergency Service: One year Cross-sectional Analysis

ÇETİN>¹,

Bektaş²,

ÖZTÜRK³

et al. 2022

HMJ

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IntroductionTrauma is a important cause of mortality and morbidity in the world. Lay out and prevent the causes of trauma will significantly affect the quality of patient care and the quality of patients' lives. The purpose of this study is to identify the characteristics of trauma patients who refer to the emergency room and assess the mortality impact of pathologies that patients have. Materials and MethodsIn this study, 14423 trauma patients who admitted to tertiary care emergency department between January 1, 2019 and December 31, 2019 were retrospectively evaluated by using the hospital information management system. The trauma types of these patients were evaluated together with their radiological imaging, and their effects on hospital discharge, hospitalization and survival were evaluated. The analysis of the data obtained has reached by SPSS and MEDCALC program. ResultsIt was determined that 8948 (62%) of 14423 patients included in our study were male and 5475 (38%) were female. It was found that the median age of the patients was 24 (IQR:25). 1680 (11.6%) of patients had head trauma, spinal trauma in 203 (1.4%), thorax trauma in 461 (3.2%), abdomen trauma in 209 (1.5%), and extremity related trauma in 4157 (28.8%) patients were found in the study. In our study, 12630 (87.6%) were discharged from the emergency department, 1747 (12.1%) were hospitalized, 16 (0.111%) died in the emergency room, and 30 (0,2%) of patients were transferred to another hospital. 1747 patients who were hospitalized, 40 (53.8%) of them were operated at least once during their hospitalization. 43 patients (2.4%) died after hospitalization. When the effects of the pathologies of the patients included in the study on mortality were evaluated; presence of scalp incisions, ventricular hemorrhage, subarachnoid hemorrhage, spinal fracture, rib fracture, lung contusion, presence of intra-abdominal fluid were statistically significant with mortality. ConclusionKnowing the epidemiological characteristics, current trauma and trauma mechanisms of trauma patients with a significant share in emergency services admissions will be important in predicting morbidity and mortality. Comprehensive and multicenter studies are needed more to increase the quality of patient care and to effect morbidity and mortality.

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“…According to a study by Beshay M. et al, the presence of contusion was found to be associated with mortality (9).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Trauma Patients Admitted to a Tertiary Care University Hospital Emergency Service: One year Cross-sectional Analysis

ÇETİN>¹,

Bektaş²,

ÖZTÜRK³

et al. 2022

HMJ

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“…Most of the previously performed studies demonstrate the use of different types of substances, mostly from the range of biomaterials (e.g., hydroxyapatite crystals, nanostructures) that are functionalized with Lf and with promising results in tissue engineering [ 38 , 61 ]. The antimicrobial properties of Lf are the most studied [ 36 , 61 , 62 , 63 ]. Several mechanisms are involved in this activity, such as iron chelation, thus depriving microorganisms of this nutrient, or direct interaction with bacterial surface components [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Bioactive Potential of Functionalized Injectable Platelet-Rich Plasma

et al. 2023

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Injectable platelet-rich fibrin (iPRF) is a frequently used platelet concentrate used for various medical purposes both in veterinary and human medicine due to the regenerative potential of hard and soft tissues, and also because of its antimicrobial effectiveness. This in vitro study was carried out to assess the cumulative antimicrobial and antibiofilm effect of iPRF functionalized with a multifunctional glycoprotein, human lactoferrin (Lf). Thus, the ability to potentiate cell proliferation was tested on keratinocytes and evaluated by the CCK8 test. The combinations of iPRF and Lf induced an increase in the proliferation rate after 24 h. The average cell viability of treated cultures (all nine variants) was 102.87% ± 1.00, and the growth tendency was maintained even at 48 h. The highest proliferation rate was observed in cultures treated with 7% iPRF in combination with 50 µg/mL of Lf, with an average viability of 102.40% ± 0.80. The antibacterial and antibiofilm activity of iPRF, of human lactoferrin and their combination were tested by agar-well diffusion (Kirby–Bauer assay), broth microdilution, and crystal violet assay against five reference bacterial strains. iPRF showed antimicrobial and antibiofilm potential, but with variations depending on the tested bacterial strain. The global analysis of the results indicates an increased antimicrobial potential at the highest concentration of Lf mixed with iPRF. The study findings confirmed the hypothesized enhanced bioactive properties of functionalized iPRF against both Gram-positive and Gram-negative biofilm-producing bacteria. These findings could be further applied, but additional studies are needed to evaluate the mechanisms that are involved in these specific bioactive properties.

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“…It would even seem that LF could stimulate the proliferation of probiotic bacteria [ 63 ]. The exploration of the LF peptide mechanisms of action for the antibacterial effects mainly revealed (i) the sequestration of bacteria and their deprivation in iron (essential for their survival) by LF given its iron-binding ability [ 64 ]; (ii) the potential of LF in interacting with LPS of gram-negative bacteria, thus considerably hampering their growth [ 8 , 65 , 66 ]; (iii) the LF competency of binding with receptors on microorganisms to obstruct the transport of nutrients, thereby restraining bacterial synthesis and metabolism [ 67 , 68 ]; (iv) the inhibition of microbial enzyme activity by LF [ 67 ]; (v) the LF-mediated prevention of biofilm formation by bacteria [ 69 ]; (vi) the capacity of LF to release antibacterial peptide lactoferricin and other bioactive peptides following hydrolysis by pepsin [ 70 , 71 , 72 ]; and (vii) the direct antimicrobial activities exerted by LF [ 73 ]. It should be noted that the impact of LF is not limited to bacteria, but can also extend to antivirals [ 74 , 75 , 76 ], antiprotozoal [ 77 ], and antifungal [ 78 ] activities.…”

Section: General Lactoferrin Propertiesmentioning

confidence: 99%

Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders

et al. 2023

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Milk-derived bioactive proteins have increasingly gained attention and consideration throughout the world due to their high-quality amino acids and multiple health-promoting attributes. Apparently, being at the forefront of functional foods, these bioactive proteins are also suggested as potential alternatives for the management of various complex diseases. In this review, we will focus on lactoferrin (LF) and osteopontin (OPN), two multifunctional dairy proteins, as well as to their naturally occurring bioactive LF–OPN complex. While describing their wide variety of physiological, biochemical, and nutritional functionalities, we will emphasize their specific roles in the perinatal period. Afterwards, we will evaluate their ability to control oxidative stress, inflammation, gut mucosal barrier, and intestinal microbiota in link with cardiometabolic disorders (CMD) (obesity, insulin resistance, dyslipidemia, and hypertension) and associated complications (diabetes and atherosclerosis). This review will not only attempt to highlight the mechanisms of action, but it will critically discuss the potential therapeutic applications of the underlined bioactive proteins in CMD.

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Antibacterial properties of lactoferrin: A bibliometric analysis from 2000 to early 2022

Cited by 14 publications

References 46 publications

Characteristics of Trauma Patients Admitted to a Tertiary Care University Hospital Emergency Service: One year Cross-sectional Analysis

Characteristics of Trauma Patients Admitted to a Tertiary Care University Hospital Emergency Service: One year Cross-sectional Analysis

Enhanced Bioactive Potential of Functionalized Injectable Platelet-Rich Plasma

Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders

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