Antibacterial Properties of Copper Nanoparticle Dispersions: Influence of Synthesis Conditions and Physicochemical Characteristics

Godymchuk, Anna; Frolov, G. A.; Gusev, Alexander; Zakharova, Olga V.; Yunda, Elena; Кузнецов, Денис; Kolesnikov, Еvgeny

doi:10.1088/1757-899x/98/1/012033

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…However, there is some evidence that the use of silver compounds may result in local skin irritation and discoloration [13]. Furthermore, copper compounds have been described as a low-cost alternative to silver, with high potential for the development of medical devices with powerful antibacterial properties [11,12]. The addition of nanoparticles of copper to polymers and the resulting antimicrobial properties have promising applications in the development of transitional prostheses [12].…”

Section: Discussionmentioning

confidence: 99%

“…Previous investigations [11,12] have shown that copper compounds have a high potential for use in the development of low-cost medical devices with powerful antibacterial properties. These positive characteristics and the high environmental safety of copper makes it capable of replacing silver and other antimicrobial compounds in the development of a wide range of medical devices [11]. Furthermore, a previous investigation reported side effects after using compounds with silver, including local skin irritation, discoloration, or staining, which are harmless and usually reversible [13].…”

Section: Introductionmentioning

confidence: 99%

“…This information is crucial for the implementation of 3D printed prostheses as post-operative or transitional prostheses. Based on previous investigations [11][12][13][14][16][17][18][19], we hypothesized that (i) antibacterial 3D printed filaments can be used for the development of functional upper-limb prostheses and (ii) the antibacterial properties of the 3D printing filament after extrusion and development of the prosthesis do not affect the antibacterial properties of the filament.…”

Section: Introductionmentioning

confidence: 99%

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3D Printed Antibacterial Prostheses

Zúñiga

2018

Applied Sciences

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The purpose of the current investigation was two-fold: (i) to describe the development of 3D printed prostheses using antibacterial filaments and (ii) to verify the antibacterial properties of the 3D printed prostheses. Three-dimensional printed finger prostheses were manufactured using PLACTIVETM antibacterial 3D printing filaments. Two adults with left index finger amputations at the proximal phalanx were fitted with a customized 3D printed finger prosthesis manufactured with an antibacterial filament. The manual gross dexterity was assessed during the Box and Block Test. Patient satisfaction was assessed using the Quebec User Evaluation of Satisfaction with assistive Technology (QUEST 2.0). Bacterial analysis of the 3D printed prostheses was performed by two independent laboratories against Staphylococcus aureus and Escherichia coli (ISO 22196). Two customized 3D printed partial finger prostheses were manufactured using a 3D printed antibacterial filament. The bacterial analysis showed that PLACTIVETM with 1% antibacterial nanoparticles additives was up to 99.99% effective against Staphylococcus aureus and Escherichia coli. The manual gross dexterity assessed was improved after using the 3D printed partial finger prosthesis. The research subjects indicated that they were “quite satisfied” to “very satisfied” with the 3D printed partial finger prosthesis. The present investigation showed that the antibacterial 3D printed filament can be used for the development of functional and effective antibacterial finger prostheses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D Printed Antibacterial Prostheses

Zúñiga

2018

Applied Sciences

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“…The antibacterial and antiviral properties of copper (compound of the PLACTIVE TM filament additives) have been shown in previous works [17][18][19]21], making it a low-cost alternative to silver [12,17,18]. Additionally, the authors in [12] showed that the antibacterial properties of the PLACTIVE TM filament after extrusion is not affected.…”

Section: Discussionmentioning

confidence: 90%

“…PLACTIVE™ is a polylactic acid polymer with copper nanoparticle additives with a high antimicrobial (antiviral and antibacterial) potential that makes it of great interest for 3D printing of orthoses, prostheses, and medical instruments [12][13][14][15][16]. Scientific publications have shown that copper has antibacterial properties [17,18], and that inhibits the replication and propagation abilities of respiratory viruses [19][20][21]. In addition, authors in [12] showed that PLACTIVE™ filament keeps its antibacterial properties after extrusion.…”

Section: Introductionmentioning

confidence: 99%

User-Tailored Orthosis Design for 3D Printing with PLACTIVE: A Quick Methodology

et al. 2021

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This paper proposes a methodology for user-tailored orthosis design for 3D printing that aims to give a non-expert, user-oriented tool that easily generates a customized orthosis. Additionally, this work aims to verify the biocompatibility of the PLACTIVE TM (PLACTIVE AN1TM, nano-additive concentration 1%, Copper 3D, Santiago, Chile) filament after extrusion to check its feasibility for 3D printed orthoses. A forefinger and a thumb orthosis were successfully designed applying the proposed methodology. The results showed that the proposed methodology is able to generate simple and practical orthoses through a fairly easy and intuitive procedure. Furthermore, experimental tests showed that the biocompatibility of the PLACTIVE TM filament is not affected after extrusion process, suggesting that it is a feasible material for 3D-printed orthoses.

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