Antibacterial properties of Allium sativum L. against the most emerging multidrug-resistant bacteria and its synergy with antibiotics

Abstract

Garlic has long been known as the most effective plant species in treatment of bacterial infections. Considering the vast potential of garlic as a source of antimicrobial drugs, this study is aimed to evaluate the antibacterial activity of Allium sativum extracts and their interactions with selected antibiotics against drug-sensitive and multidrug-resistant isolates of emerging bacterial pathogens that are frequently found in healthcare settings. As shown by the in vitro data obtained in this study, the whole Allium sativum extract inhibited the growth of a broad range of bacteria, including multidrug-resistant strains with bactericidal or bacteriostatic effects. Depending on the organism, the susceptibility to fresh garlic extract was comparable to the conventional antibiotic gentamycin. Since the combinations of fresh garlic extract with gentamycin and ciprofloxacin inhibited both the drug sensitive and MDR bacteria, in most cases showing a synergistic or insignificant relationship, the potential use of such combinations may be beneficial, especially in inhibiting drug-resistant pathogens. The study results indicate the possibility of using garlic as e.g. a supplement used during antibiotic therapy, which may increase the effectiveness of gentamicin and ciprofloxacin.

Biogenic Synthesis, Characterization and Antibacterial Potential Evaluation of Copper Oxide Nanoparticles Against Escherichia coli

“…Antimicrobial activity against a wide range of microbes has been manifested by aqueous extracts of ginger, owing to its phenolic contents of therapeutic nature [ 4 ]. Allium sativum commonly known as garlic contains phenolic compounds exhibiting a broad-spectrum antibacterial activity even against MDR bacteria [ 5 ]. Allium sativum has exhibited broad-spectrum antibacterial activity against a number of Gram-positive and various Gram-negative bacteria [ 6 ].…”

“…Bactericidal activity 1 (3 mL:1), 2 (6 mL:1), 3 (12 mL:1),4 Ciprofloxacin,5 DIWConclusionsBactericidal potential of CuO NPs doped with Zingiber officinale and Allium sativum extracts against pathogenic E. coli was evaluated in this study, produced with the aim of alternate, economical and effective antimicrobials. The significant role of phytochemical ingredients of ZO and AS extracts was revealed in the biogenic synthesis of CuO NPs while synergistic effects of flavonoids with CuO were found to be concentration-dependent exploiting the bactericidal potential against pathogenic E. coli.…”

A review on medicinal properties and therapeutic applications of Allium sativum (Garlic)

“…It is known that Bacillus anthrasis causing anthrax infections is the most susceptible bacteria to garlic. [59] Amir Sasan et al [60] concluded the anti-bacterial activities of Aqueous garlic extract in hamburger S.aureus. In addition, not only as a taste but as a natural component for hamburgers may be used garlic aqueous extract.…”

Progress in Immunoassays of Toxic Alkaloids in Plant-Derived Medicines: A Review

“…Owing to the outstanding advantages, such as the nature of the original compounds, the functionality of a lot of active ingredients, and the low cost of a wide range of sources, plant-derived medicines are becoming more and more popular with consumers worldwide. In the current era of widespread antibiotic resistance, plant-derived medicines such as garlic have remarkably persisted over time and continue to be used today for indications similar to those described historically, which can be used as alternative antibiotic resources [ 5 ]. In addition, plant-derived medicines as functional foods have made a significant contribution to human or animal health [ 6 ].…”