Antibacterial potential of Saussurea obvallata petroleum ether extract: A spiritually revered medicinal plant

Abstract

Uttarakhand Himalayan region holds Asteraceae or Compositae as the largest family of flowering, medicinal and aromatic plants. Species belonging to this family rises from low altitude to the alpine region. Among Asteraceae, Saussurea obvallata (DC.) Edgew. is widely used in several indigenous systems of medicine. Flowers, leaves and rhizomes of S. obvallata are used for several traditional, religious, therapeutic and ornamental purposes. Aim of this study was to determine the chemical composition and antibacterial efficacy of petroleum ether extract (PEE) of S. obvallata. Gas chromatography-mass spectrometry (GC-MS) analysis was used for identifying phytochemicals present in the plant extract. Furthermore, the PEE was assessed for in-vitro antibacterial activity against selected Gram positive and negative strains. Structure of squalene and α-linolenic acid methyl ester were identified in PEE by GC-MS analysis, by comparing the results obtained with NIST library and literature reports. PEE exhibited significant activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus, Bacillus subtilis with IC 50 value of 87.2 ± 1.6, 98.4 ± 1.1 and 90.2 ± 1.8 µg/ml, respectively. These results showed that squalene and α-linolenic acid derivative identified in S. obvallata may be responsible for the observed antibacterial activity. To the best of our knowledge, this is the first report focused on the chemical composition and antibacterial activity of S. obvallata.

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Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

“…Medicinal plants have been used in human pharmacologic treatments for a long time (Mishra, Saklani, Sharifi‐Rad, Iriti, Salehi, Maurya, et al, ; Mishra, Saklani, Salehi, et al, ; Prakash et al, ; Salehi, Sharopov, et al, ; Salehi, Valussi, et al, ; M. Sharifi‐Rad, Fokou, et al, ; M. Sharifi‐Rad, Nazaruk, et al, ; M. Sharifi‐Rad, Roberts, et al, ). Stevia is one of these species with healthy properties and is used especially in South America and some Asian regions (Lemus‐Mondaca et al, ).…”

“…Medicinal plants have been used in human pharmacologic treatments for a long time (Mishra, Saklani, Sharifi-Rad, Iriti, Salehi, Maurya, et al, 2018;Prakash et al, 2018;Salehi, Sharopov, et al, 2018;Salehi, Valussi, et al, 2018 Marcinek & Krejpcio, 2016).…”

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