In this work, water soluble CdTe quantum dots (QDs) were incorporated into a biopolymeric matrix of polyacrylamide grafted onto cationic starch (CS-g-PAAm) to enhance optical properties of QDs. To this aim, the effect of various factors such as AAm concentration, molar ratio of CS-g-PAAm/CdTe, reaction temperature and time on optical properties of obtained QDs were investigated via UV-visible (UV-vis) and fluorescence spectra. Finally, the optimized QDs were characterized by Fourier transform infrared (FT-IR), transmission electron microscopy (TEM), thermo-gravimetric (TG) analysis, and energy dispersive X-ray analysis (EDX).