Antibacterial potential of ellagic acid and gallic acid against IBD bacterial isolates and cytotoxicity against colorectal cancer

Cota, Damita; Patil, Dhanashree

doi:10.1080/14786419.2022.2111560

Cited by 8 publications

(10 citation statements)

References 21 publications

(1 reference statement)

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“…It has been widely used as an antioxidant additive in food. The addition of gallic acid has potentiated antimicrobials’ effectiveness against various pathogenic bacteria [ 47 ]. Accordingly, gallic acid could be applied as a promising compound for new antimicrobial drug development.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI)

Zhang,

Niu,

Yin

et al. 2023

Antibiotics

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A novel antimicrobial peptide, GAPI, has been developed recently by grafting gallic acid (GA) to polyphemusin I (PI). The objective of this study was to investigate the antibacterial effects of GAPI on common oral pathogens. This laboratory study used minimum inhibitory concentrations and minimum bactericidal concentrations to assess the antimicrobial properties of GAPI against common oral pathogens. Transmission electron microscopy was used to examine the bacterial morphology both before and after GAPI treatment. The results showed that the minimum inhibitory concentration ranged from 20 μM (Lactobacillus rhamnosus) to 320 μM (Porphyromonas gingivalis), whereas the minimum bactericidal concentration ranged from 80 μM (Lactobacillus acidophilus) to 640 μM (Actinomyces naeslundii, Enterococcus faecalis, and Porphyromonas gingivalis). Transmission electron microscopy showed abnormal curvature of cell membranes, irregular cell shapes, leakage of cytoplasmic content, and disruption of cytoplasmic membranes and cell walls. In conclusion, the GAPI antimicrobial peptide is antibacterial to common oral pathogens, with the potential to be used to manage oral infections.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI)

Zhang,

Niu,

Yin

et al. 2023

Antibiotics

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“…It strongly inhibits the growth of various bacteria, including antibiotic-resistant S. aureus , E. coli , Mannheimia haemolytica , and Pasteurella multocida strains [ 36 ], by inhibiting efflux pumps and folate metabolism. Additionally, gallic acid can potentiate the efficacy of antimicrobials [ 37 ]. To verify the important role of trihydroxybenzene, we selected four gallic acid analogues, containing trihydroxybenzene or not, to detect the inhibition.…”

Section: Discussionmentioning

confidence: 99%

Structural Basis of the Inhibition of L-Methionine γ-Lyase from Fusobacterium nucleatum

Lan

et al. 2023

IJMS

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Fusobacterium nucleatum is a lesion-associated obligate anaerobic pathogen of destructive periodontal disease; it is also implicated in the progression and severity of colorectal cancer. Four genes (FN0625, FN1055, FN1220, and FN1419) of F. nucleatum are involved in producing hydrogen sulfide (H2S), which plays an essential role against oxidative stress. The molecular functions of Fn1419 are known, but their mechanisms remain unclear. We determined the crystal structure of Fn1419 at 2.5 Å, showing the unique conformation of the PLP-binding site when compared with L-methionine γ-lyase (MGL) proteins. Inhibitor screening for Fn1419 with L-cysteine showed that two natural compounds, gallic acid and dihydromyricetin, selectively inhibit the H2S production of Fn1419. The chemicals of gallic acid, dihydromyricetin, and its analogs containing trihydroxybenzene, were potentially responsible for the enzyme-inhibiting activity on Fn1419. Molecular docking and mutational analyses suggested that Gly112, Pro159, Val337, and Arg373 are involved in gallic acid binding and positioned close to the substrate and pyridoxal-5′-phosphate-binding site. Gallic acid has little effect on the other H2S-producing enzymes (Fn1220 and Fn1055). Overall, we proposed a molecular mechanism underlying the action of Fn1419 from F. nucleatum and found a new lead compound for inhibitor development.

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“…However, gallic and ellagic acids, major phytoconstituents of leaves, reportedly work as antibacterial agents [52]. Previous evidence indicated in vitro antibacterial activity of T. bellirica fruit extracts [53].…”

Section: Discussionmentioning

confidence: 99%

Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts in Northern Thailand

Khonthun

Khoothiam

Chumphukam

et al. 2023

FFHD

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Background: Aging is a process caused by oxidants and aging-related enzymes. Therefore, the inhibition of these processes can exacerbate anti-aging agents. This study aimed to evaluate the antioxidant and anti-aging activities of leaf extracts from seven herbs used in traditional Thai herbal remedies. Methods: Researchers assessed the total levels of phenolic content (TPC), antioxidant, anti-collagenase, and anti-tyrosinase activity using colorimetric methods. Cytotoxicity effects were determined using MTT assays, and matrix metalloproteinases(MMPs) secretion was assessed through gelatin zymography. In addition, inhibitory effects on the growth of microorganisms were examined using the disc diffusion and broth microdilution method.Results: TPC ranged between 48.68–440.91 mg GAE/g of ethanolic leaf extracts. High antioxidant activities against ABTS radicals were detected in P. granatum, P. emblica, P. guajava, T. bellirica, and T. chebula, while high DPPH neutralization appeared in M. coreia, P. guajava, and P. granatum. FRAP assays significantly reduced the power of T. chebula and P. granatum. T. chebula and P. guajava exhibited the highest inhibitory effect on H2O2induced ROS production. P. emblica, P. guajava, T. bellirica, and E. hygrophilus reduced tyrosinase and collagenase activities. P. gaujava, T. chebula, and T. bellirica were shown to inhibit the secretion of MMP-2 from fibroblast cells. All concentrations of leaf extracts were non-toxic to fibroblast cells. P.granatum and T. bellirica could inhibit the growth of P. acnes, E. coli, and S. aureus. Conclusion: Preliminary studies showed that P.granatum and T. bellirica leaf extracts have antioxidants, anti-aging, and anti-bacterial activities, as well as active ingredients suitable for cosmetic products.Keywords: antioxidants, anti-aging, leaf extracts

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Antibacterial potential of ellagic acid and gallic acid against IBD bacterial isolates and cytotoxicity against colorectal cancer

Cited by 8 publications

References 21 publications

Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI)

Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI)

Structural Basis of the Inhibition of L-Methionine γ-Lyase from Fusobacterium nucleatum

Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts in Northern Thailand

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