Antibacterial Potential of Bryophyllum pinnatum Leaf Extracts on Bacteria Obtained from Infected Infant Respiratory Tract

Etim, Lawrence B.; Obande, Godwin Attah; Chuku, Aleruchi; Bassey, Victoria M.

doi:10.9734/bjpr/2016/24757

Cited by 9 publications

(5 citation statements)

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“…Furthermore, the maximum activity of Bryophyllum pinnatum was obtained from the leaf extract using methanol biofraction containing 100mg/ml concentration followed by ethanol biofraction with concentration of 100mg/ml. This was in accordance with the reports of [39,40,41,42] but partially in consonance to the report of [43] who reported the effectiveness of the ethanol extract derived from Bryophyllum pinnatum plant by exhibiting the best biological activities at 4 mm for Staphylococcus aureus. Meanwhile, the activity of Rauvol a vomitoria leaf was discovered to be at maximum using ethanol biofraction at 100mg/ml followed by methanol biofraction at 100mg/ among the four solvents biofractions used against GBS with mean inhibition diameter ranging from (15mm-23mm).…”

Section: Molecular Identification Of Tet(o) and Erm(b) Genessupporting

confidence: 93%

Bioactivity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

Ojo

Udewena

Adetunji

2022

GA – 70th Annual Meeting 2022

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BackgroundGroup B Streptococcus (GBS) is a harmless commensal bacterium in healthy adults but it causes sepsis in neonates resulting in a high rate of mortality. This study was carried out to investigate the antibacterial activity of Bryophyllum pinnatum and Rauvol a vomitoria bioactive fractions on thirty-ve multidrug resistant Group B Streptococcus (GBS) strains implicated on neonatal sepsis as well as to identify the antibiotic resistant genes present. The phytochemical analyses were carried out using column chromatography. Antibacterial activity, Minimum Inhibitory Concentration (MIC) and Minimum Bacteria Concentration (MBC) of the different plant biofractions was determined using disc diffusion technique. The presence of erythromycin (ermB) and tetracycline (tetO) resistant genes was identi ed using duplex PCR techniques. Graphing was done using Graph pad prism (version 5.0a). ResultThe results obtained from this study show that the selected plants have dose dependent activity against GBS. Ethanol biofraction of R. vomitoria had the highest activity with an MIC value ranges between 12.5 mg/ml and 50 mg/ml and MBC ranges from 25 mg/ml and 50 mg/ml followed by methanol biofraction of B. pinnatum with an MIC value ranging between 50mg/ml and 100mg/ml on 32 out of the 35 strains investigated, leaving the other three having MIC values of 25 mg/ml then MBC values ranging between 50 mg/ml and 100mg/ml while N-hexane and aqueous biofractions had the least activity. Also, the presence of ermB and tetO resistant genes were present in all the ten representative GBS strains tested. ConclusionThe high rate of activity shown by the methanol and ethanol extracts of both plants suggests that the plants can serve as a potential alternative for the treatment of neonatal sepsis. However, a further study on their in vivo activity is important in order to evaluate the e ciency, safety and potential adverse effects and drug herb interactions of the plants.

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Section: Molecular Identification Of Tet(o) and Erm(b) Genessupporting

confidence: 93%

Bioactivity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

Ojo

Udewena

Adetunji

2022

GA – 70th Annual Meeting 2022

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“…The highest level of activity of Bryophyllum pinnatum was achieved using a methanol biofraction of the leaf extract at a concentration of 100 mg/mL, followed by an ethanol biofraction at the same concentration (Figure 1). This finding aligns with the studies conducted by Akinsulere et al 29 , Ofokansi et al 30 , Etim et al 31 , and Obioma et al 32 . However, it is only partially consistent with the findings of Obi and Onuoha 33 , who reported that the ethanol extract derived from the Bryophyllum pinnatum plant showed the highest biological activity against Staphylococcus aureus at a concentration of 4 mm.…”

Section: Antibacterial Susceptibility Pattern Of Bioactive Fractions ...supporting

confidence: 92%

Antibacterial Activity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

2024

TJNPR

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Medicinal plants are a promising alternative as they contain a diverse array of biologically active compounds that can be utilized in the treatment of various chronic infectious diseases. This could be associated with their cost-effectiveness and minimal side effects. 8 In the western region of Nigeria, various native plants, like Bryophyllum pinnatum, Azadirachta indica, Rauvolfia vomitoria, Mangifera indica, Allium cepa, and Mormodic acharantia, are used to treat infant diseases. 9 However, it is necessary to scientifically validate the traditional medicinal claims by investigating the antibacterial properties of Bryophyllum pinnatum and Rauvolfia vomitoria against neonatal sepsis caused by Group B Streptococcus (GBS). 10 This study aims to assess the antibacterial effects of Bryophyllum pinnatum and Rauvolfia vomitoria against GBS strains that cause neonatal sepsis, as well as identify the presence of tet (O) and erm (B) genes in these strains. Materials and Methods Sample Collection and Strain ConfirmationThe thirty-five GBS strains used in this study were neonatal clinical isolates of GBS, all resistant to both tetracycline (MIC, ≥ 8µg/ml) and erythromycin (MIC, ≥1µg/ml) and were obtained from the

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“…isolated from the respiratory tract of infants. The findings confirmed the usefulness of the plant extract in the treatment of infant respiratory infections and as a promising antibacterial agent in the pharmaceutical industry [28]. Górniak et al suggested that bioactive compounds from plant extract have antibacterial properties since they can constrain bacterial DNA replication, disrupt bacterial cell walls, inhibit biofilm formation and reduce the production of bacterial toxins to the host [29].…”

Section: Antimicrobial Activitymentioning

confidence: 54%

Antimicrobial Activity of Kalanchoe Pinnata: A Review

Tajudin

Ismail

2022

MJoSHT

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Kalanchoe pinnata (synonym to Byrophyllum pinnatum) or commonly known as “Setawar” is a medicinal plant belongs to the Crassulaceae family. It is also known as “life plant” and “resurrection plant” due to its multiple roles in traditional medication. The therapeutic values of K. pinnata mostly lie on the presence of phytochemicals or plant active compounds which possess high potential as a natural antimicrobial agent source. Given the global health threat of antimicrobial resistance towards synthetic drugs, uncovering the natural sources as a novel drug is of crucial need. In this regard this review highlights the antimicrobial property of K. pinnata extract, the bioactive compound analysis of this plant extract and their mode of action against pathogenic microorganisms. The potent bioactive compounds extracted from K. pinnata plant could be further explored as an alternative medicine to the current synthetic antimicrobial drugs.

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Antibacterial Potential of Bryophyllum pinnatum Leaf Extracts on Bacteria Obtained from Infected Infant Respiratory Tract

Cited by 9 publications

References 0 publications

Bioactivity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

Bioactivity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

Antibacterial Activity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus

Antimicrobial Activity of Kalanchoe Pinnata: A Review

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