Antibacterial potential of Antarctic lichens against human pathogenic Gram‐positive bacteria

Paudel, Bishnu Hari; Bhattarai, Hari Datta; Lee, Jin Sung; Hong, Soon Gyu; Shin, Hyun Woung; Yim, Joung Han

doi:10.1002/ptr.2445

Cited by 52 publications

(32 citation statements)

References 9 publications

(10 reference statements)

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“…These results against S. aureus are similar to many other studies (Gulluce et al, 2006;Paudel et al, 2008Paudel et al, , 2012Srivastava et al, 2013). We found that all crude extracts of the tested lichen species except for Lobaria pulmonaria and Umbilicaria mammulata were found to be active against S. aureus.…”

Section: Discussionsupporting

confidence: 92%

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Shrestha

Raphael

Leavitt

et al. 2014

Pharmaceutical Biology

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Context: The emergence of antibiotic resistant pathogens is a serious global health threat. Hence, the search for new antibiotic drugs from various natural sources should be given high priority. Lichens produce a variety of low molecular weight metabolic compounds and many cultures have utilized these compounds in traditional medicine for centuries. Objective: Report the antibiotic properties of extracts from 34 North American lichens screened against four pathogenic bacteria. Materials and methods: The micro-well dilution method was used to determine the minimum inhibitory concentration (MIC) of acetone and methanol extracts of 34 lichen species against four bacterial strains. Major chemical compounds in each species were identified using thin layer chromatography (TLC). Results: Most of the lichen extracts demonstrated inhibitory effects against Staphylococcus aureus, Pseudomonas aeruginosa, and methicillin-resistant S. aureus (MRSA) with MIC values ranging from 3.9 to 500 mg/ml. In addition, extracts from three species, Letharia columbiana (Nutt.) J. W. Thomson (Parmeliaceae), Letharia vulpina (L.) Hue (Parmeliaceae), and Vulpicida canadensis (Räsänen) J.-E. Mattsson & M. J. Lai (Parmeliaceae) (MIC ¼ 125-500 mg/ml) were also effective against Escherichia coli. Generally, acetone extractions were found to be more effective than methanol extractions. Discussion and conclusion: Results of this study show that lichen extracts provide significant antimicrobial activity against both Gram-positive and Gram-negative bacteria. These results suggest that lichens may be an important potential source of antibacterial drugs.

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Section: Discussionsupporting

confidence: 92%

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Shrestha

Raphael

Leavitt

et al. 2014

Pharmaceutical Biology

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“…During our previous preliminary screening study (Paudel et al, 2008b), the methanol extract of R. terebrata showed antibacterial activity against Gram-positive pathogenic bacteria. The further work of isolation of bioactive compounds gave fi ve compounds as described above.…”

Section: Antibacterial Activities Of the Isolated Compoundsmentioning

confidence: 97%

Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

Paudel

Bhattarai

Lee

et al. 2010

Zeitschrift Für Naturforschung C

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The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method while the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 μg/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis.

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“…In order to prevent spreading of infection by antibiotic resistant microbes, scientists have been conducting intensive researches to determine new alternative antimicrobial agents (Paudel et al, 2008;Özkan et al, 2015). Huge number of studies presented that natural products have been used for hundreds of years to treat several diseases caused by bacteria, fungi, viruses and parasites (Jones, 1996;Onbaşılı et al, 2011;Onbaşlı et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial Activity Screening of Xylaria Hypoxylon

Canlı¹,

Akata²,

Altuner³

2016

Afr J Tradit Complement Altern Med

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Background: Fungi have a potential of using both as nutritive and medicinal food stuff. Because of containing several therapeutic agents, they are reported to be used for hundreds of years to treat several diseases caused by bacteria, fungi, viruses and parasites. The aim of this study is to determine the in vitro antimicrobial activity of Xylaria hypoxylon, which were collected from Yomra, Trabzon, Turkey. Materials and Methods: X. hypoxylon samples were air dried and extracted by using ethanol. Results: It is observed that ethanol extracts of X. hypoxylon has antimicrobial activity against several Gram positive and Gram negative microorganisms tested. As a result of the study, an antimicrobial activity of X. hypoxylon found against most of strains used in the study. Conclusion:The results of our study clearly puts forward that X. hypoxylon could have a possible medicinal use.

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Antibacterial potential of Antarctic lichens against human pathogenic Gram‐positive bacteria

Cited by 52 publications

References 9 publications

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

In vitroevaluation of the antibacterial activity of extracts from 34 species of North American lichens

Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

In Vitro Antimicrobial Activity Screening of Xylaria Hypoxylon

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