Antibacterial potency of simple fractions of ethyl acetate extract of Begonia baliensis

Siregar, Hartutiningsih M.; Purwantoro, R. Subekti; Praptiwi,; Agusta, Andria

doi:10.13057/nusbiosci/n100305

Cited by 4 publications

(3 citation statements)

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“…The mycelium biomass of G. frondosa was extracted using a mixed solvent; the extracting yield was 54.73%. In addition to indicating the abundance of bioactive compounds in an extract, the extraction yield also represents the effectiveness and efficiency of the extraction process [19]. This extraction of G. frondosa may contain several bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Exploring the influence of maitake (Grifola frondosa) on Mus musculus learning-memory and anxiety behavior

Fadilah,

Listiyowati,

Juliandi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Progressive neurodegeneration affect memory and behavior. One solution to increase neuroprotection is the consumption of medicinal mushrooms such as Grifola frondosa. This study aims to analyze the effect of G. frondosa extract on learning-memory and anxiety levels in mice. Mycelium was cultured in Potato Sucrose Broth medium at room temperature for 14 days. Dried mycelial was extracted using a solvent mixture (22% ethyl acetate and 11% methanol). Learning-memory and anxiety levels were observed using Y-Maze Alternation (Y-Maze) test, Morris Water Maze (MWM) test, Novel Object Recognition test, and Light and Dark Transition test. A total of 18 male mice were divided into three groups and given oral treatment for 14 days: control (distilled water), GF100 (extract of 100 mg/kg BW), and GF200 (crude extract of 200 mg/kg BW). The GF100 and GF200 groups increased spatial learning-memory in Y-Maze and novel object recognition memory, but both treatment groups did not significantly affect anxiety and learning-memory in MWM.

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Section: Discussionmentioning

confidence: 99%

Exploring the influence of maitake (Grifola frondosa) on Mus musculus learning-memory and anxiety behavior

Fadilah,

Listiyowati,

Juliandi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…The Begonia is one of the largest genera of flowering plants with leaves and flowers of beautiful shapes and various colours. 13 Literature studies reveal 1.870 plant species belonging to the Begonia genera. 14 , 15 Begonia commonly used to be decorative plant and some of them are empirically used to treat various diseases, e.g., Begonia barbata C.B.…”

Section: Introductionmentioning

confidence: 99%

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

Maulana

Wahyuni

Widiyanti

et al. 2023

J. Public Health Afr.

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Background: The emergence of Coronavirus disease (COVID-19) has been declared a pandemic and made a medical emergency worldwide. Various attempts have been made, including optimizing effective treatments against the disease or developing a vaccine. Since the SARS-CoV-2 protease crystal structure has been discovered, searching for its inhibitors by in silico technique becomes possible. Objective: This study aims to virtually screen the potential of phytoconstituents from the Begonia genus as 3Cl pro-SARS-CoV- 2 inhibitors, based on its crucial role in viral replication, hence making these proteases “promising” for the anti-SARS-CoV-2 target. Methods: In silico screening was carried out by molecular docking on the web-based program DockThor and validated by a retrospective method. Predictive binding affinity (Dock Score) was used for scoring the compounds. Further molecular dynamics on Desmond was performed to assess the complex stability. Results: Virtual screening protocol was valid with the area under curve value 0.913. Molecular docking revealed only β-sitosterol-3-O-β-D-glucopyranoside with a lower docking score of - 9.712 kcal/mol than positive control of indinavir. The molecular dynamic study showed that the compound was stable for the first 30 ns simulations time with Root Mean Square Deviation <3 Å, despite minor fluctuations observed at the end of simulation times. Root Mean Square Fluctuation of catalytic sites HIS41 and CYS145 was 0.756 Å and 0.773 Å, respectively. Conclusions: This result suggests that β-sitosterol-3-O-β-D- glucopyranoside might be a prospective metabolite compound that can be developed as anti-SARS-CoV-2.

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“…More than 10.000 hybrids of Begonia have been produced known worldwide (Kiew et al, 2015). Begonia is used for medicines due to its bioactive compound, as reported by Hartutiningsih et al (2018) on B. baliensis. Locally, B. lombokensis and B. longifolia are also eaten and/or used medicine and food (Girmansyah, 2009).…”

Section: Introductionmentioning

confidence: 99%

Leaf Anatomy Profile of Begonia Section Platycentrum Sphenanthera Group From Java and Sumatera, Indonesia

Lailaty,

Efendi

2023

Jurnal Biodjati

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Anatomical studies have been used in the classification and identification of Begonia species. However, the research on Indonesian native Begonia is still limited. This study focused to evaluate the importance of leaves’ anatomy character for the identification and classification purpose of the Sphenanthera group in Java and Sumatra. A total of six individuals of four Begonia species used in this study, namely Begonia multangula, B. longifolia, B. pseudoscottii, and B. robusta. This study aimed to describe the anatomical characters of the leaves that are useful in the identification and grouping of Begonia section Platycentrum–Sphenanthera. The anatomical preparations used the paraffin method for the cross-section of leaves and the semi-permanent method for paradermal observations. In general, the epidermal cells of paradermal Begonia leaves are polygonal in shape. Consistently, Begonias have single-type stomata with an anisocytic type which are only present on the abaxial leaves. Begonia Sphenanthera group has a thin cuticle (less than 2 µm), both in the abaxial and adaxial surfaces. The lower epidermis cells are smaller than the upper epidermis cells. The mesophyll is differentiated into palisade and spongy tissue. The number and form of mesophyll tissue are varied, therefore useful for diagnosing an important character in the grouping of Begonias from this section.

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Antibacterial potency of simple fractions of ethyl acetate extract of Begonia baliensis

Cited by 4 publications

References 1 publication

Exploring the influence of maitake (Grifola frondosa) on Mus musculus learning-memory and anxiety behavior

Exploring the influence of maitake (Grifola frondosa) on Mus musculus learning-memory and anxiety behavior

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

Leaf Anatomy Profile of Begonia Section Platycentrum Sphenanthera Group From Java and Sumatera, Indonesia

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