Antibacterial, physicochemical and mechanical properties of endodontic sealers containing quaternary ammonium polyethylenimine nanoparticles

Barros, Joana; Silva, M. G.; Rodrigues, Marco Aurélio; Alves, Flávio R.F.; Lopes, M. A.; Pina‐Vaz, Irene; Siqueira, José F.

doi:10.1111/iej.12207

Cited by 57 publications

(42 citation statements)

References 33 publications

(73 reference statements)

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“…27,28 The repulsive action could be associated with the orientation of the surfactant in the sealer where the hydrophobic chains would interact with the hydrophobic components of the sealer while the hydrophilic part would be located on the surface and interact with the bacterial cell membranes decreasing the adhesive potential. 29 These findings are also in accordance with the contact angle results. In fact, the measured contact angles were reduced with the addition of BC.…”

Section: Discussionsupporting

confidence: 88%

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

Arias-Moliz

Ruiz-Linares

Cassar

et al. 2015

Journal of Dentistry

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Section: Discussionsupporting

confidence: 88%

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

Arias-Moliz

Ruiz-Linares

Cassar

et al. 2015

Journal of Dentistry

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“…, Barros et al . ). Glass–ionomer‐based cements had a resistance 1.82 MPa higher than zinc oxide‐eugenol‐based sealers, probably due to the adhesive characteristic of ionomeric cements (Schwartz ).…”

Section: Discussionmentioning

confidence: 97%

The influence of methodological variables on the push‐out resistance to dislodgement of root filling materials: a meta‐regression analysis

et al. 2015

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Collares FM, Portella FF, Rodrigues SB, Celeste RK, Leitune VCB, Samuel SMW. The influence of methodological variables on the push-out resistance to dislodgement of root filling materials: a meta-regression analysis. International Endodontic Journal, 49, 836-849, 2016. The aim of this systematic review was to evaluate the influence of several methodological variables on the push-out resistance to dislodgment of root filling materials by a meta-regression analysis of the literature. A systematic review was performed by searching the PubMed database using the terms 'push-out' and 'pushout'. Laboratory studies published before March 2015 were included. Two reviewers extracted data regarding country of origin, year of publication, tooth type, smear layer removal, root canal sealer, core material, obturation technique, sample storage, tooth portion, test machine load velocity and slice thickness. Pooled mean resistance to dislodgement of all groups from the included studies was used in a linear meta-regression of random effects (a = 0.05). Of the 850 identified studies, 53 met the inclusion criteria. A meta-regression of the 341 groups extracted from these articles was performed to analyse the influence of each variable on resistance to dislodgement (in MPa). The sealer, core material, obturation technique, slice thickness, storage time, load velocity and tooth portion significantly influence the results (P < 0.05). Irrigant solution and smear layer removal did not influence the resistance to dislodgement of the root filling materials (P > 0.05). Methodological variables such as sealer, core material, root filling technique, tooth type, tooth portion, slice thickness, storage time and load velocity influenced the resistance to dislodgment. The inclusion and standardization of all related variables could lead to a more comparable and reproducible analysis of the resistance to dislodgment of the root canal sealers.

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“…Regarding the results of comparing Log CFU/mL averages of AgNP-CM and sterile saline solution, the wild strain showed a relative increase during the 5-minute contact; nonetheless, there was no significant statistical difference for the 5-minute or the 30-minute contact. In a study of quaternary ammonium polyethylenimine (QPEI) nanoparticles added to two luting cements, the antibacterial effect only after 60-minute contact with E. faecalis RW35, whereas in the ATCC29212 strain, the effect was evident only after 10-minute contact (28). In our study, the antibacterial efficacy of AgNP nanoparticles for the treatment of a wild strain of E. faecalis was lower when compared to the ATCC29212 strain.…”

Section: Discussionmentioning

confidence: 50%

“…Similar studies recommended the use of isolated wild native strains for antibacterial efficacy studies in order to compare their behavior with standard ATCC29212 strain, which is the most studied species (28). Regarding the results of comparing Log CFU/mL averages of AgNP-CM and sterile saline solution, the wild strain showed a relative increase during the 5-minute contact; nonetheless, there was no significant statistical difference for the 5-minute or the 30-minute contact.…”

Section: Discussionmentioning

confidence: 92%

Antibacterial Efficacy of a Dispersion of Silver Nanoparticles in Citrate Medium for the Treatment of E. faecalis: an In Vitro Study

Rodríguez

Ramírez-Mora

Montero

et al. 2016

Odovtos - Int J Dent Sc

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The purpose of this study was to measure the antibacterial efficacy of a dispersion of silver nanoparticles (AgNP) in a citrate medium tested in two E. faecalis strains. AgNP were synthesized, and AgNP citrate medium (AgNP-CM) dispersion was prepared at a concentration of 100 μg/mL. The antibacterial efficacy of AgNP-CM dispersion was evaluated over two E. faecalis strains: ATCC29212 and a wild strain collected from human necrotic teeth. 5% sodium hypochlorite (NaOCl) and sterile saline solution were used as positive and negative controls. 5 and 30-minute contact tests were conducted and each experimental group were replicated 10 times. After 24 hours of incubation, the Log CFU/ mL were calculated. The AgNP obtained showed spherical shapes and had 30-60nm size. 5% NaOCl was able to completely eliminate both E. faecalis strains in all groups, showing a significant statistical difference when compared to AgNP-CM dispersion and negative control groups. AgNP-CM dispersion showed a statistically significant decrease in Log CFU/mL averages (p=0,0006) when compared to the sterile saline solution for the ATCC29212 strain during the 30-minute time. Between the 5-minute and 30-minute groups, a significant bacterial count decrease was also observed (p= 0,0128). The antibacterial efficacy of the dispersion was greater for the ATCC29212 strain than the wild strain, were the effect diminished. AgNP-CM dispersion showed a significantly lower antibacterial efficacy against E. faecalis than the 5% NaOCl at the tested times. RESUMENEl propósito del presente estudio fue medir la eficacia antibacteriana de una dispersión de nanopartículas de plata (AgNP) en medio de citrato ante dos cepas de E. faecalis. Las AgNP fueron sintetizadas y se preparó una dispersión en medio de citrato (AgNP-CM) en una concentración de 100 μg/mL. La eficacia antibacteriana de la dispersión de AgNP-CM fue evaluada ante dos cepas de E. faecalis: la ATCC29212 pura y una cepa silvestre aislada de un tratamiento endodóntico fallido. Se utilizó hipoclorito de sodio al 5% de concentración (NaOCl) y solución salina estéril como controles positivos y negativos. Se realizaron pruebas de contacto durante 5 y 30 minutos y cada grupo experimental se replicó 10 veces. Después de incubar las muestras durante 24 horas, se calcularon las concentraciones Log CFU/mL. Las AgNP obtenidas mostraron formas esféricas y un tamaño entre los 30 y 60nm. El NaOCl 5% logró eliminar por completo las cepas bacterianas en todos los grupos, mostrando una diferencia estadísticamente significativa al compararse con las dispersiones de AgNP-CM y los controles negativos. La dispersión de AgNP-CM mostró una disminución estadísticamente significativa en los promedios Log CFU/mL al compararse con la solución salina estéril para la cepa ATCC29212 a los 30 minutos de contacto. Entre los grupos de 5 y 30 minutos de la dispersión, se observó también una disminución en el conteo bacteriano (p=0,0128). La eficacia antibacteriana de la dispersión fue mayor para la cepa ATCC29212 que para la c...

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Antibacterial, physicochemical and mechanical properties of endodontic sealers containing quaternary ammonium polyethylenimine nanoparticles

Abstract: Incorporation of QPEI nanoparticles can improve the long-term antibacterial activity of Pulp Canal Sealer EWT without relevant changes in physicochemical and mechanical properties.

Cited by 57 publications

References 33 publications

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

The influence of methodological variables on the push‐out resistance to dislodgement of root filling materials: a meta‐regression analysis

Antibacterial Efficacy of a Dispersion of Silver Nanoparticles in Citrate Medium for the Treatment of E. faecalis: an In Vitro Study

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