Antibacterial peptides from thermophilic bacteria

Mikulı́k, Karel; Melčová, Magdalena; Zídková, J.

doi:10.25125/engineering-journal-ijoer-apr-2017-15

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…The development of modern physicochemical analysis and genomics, supplemented by biochemical research, has led to the development of new detection technologies that significantly accelerate the discovery of new natural phosphonates, the identification of their metabolic pathways, and their use as starting compounds for the creation of new promising drugs. Aminophosphonic and hydroxyphosphonic acids, phosphagens, phosphonopeptides, phosphonolipids, phosphorus antibiotics, agrochemicals, etc., confirm the importance of natural phosphorus compounds for science and economics [209].…”

Section: Discussionmentioning

confidence: 72%

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Kolodiazhnyi

2021

Symmetry

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Organophosphorus compounds play a vital role as nucleic acids, nucleotide coenzymes, metabolic intermediates and are involved in many biochemical processes. They are part of DNA, RNA, ATP and a number of important biological elements of living organisms. Synthetic compounds of this class have found practical application as agrochemicals, pharmaceuticals, bioregulators, and others. In recent years, a large number of phosphorus compounds containing P-O, P-N, P-C bonds have been isolated from natural sources. Many of them have shown interesting biological properties and have become the objects of intensive scientific research. Most of these compounds contain asymmetric centers, the absolute configurations of which have a significant effect on the biological properties of the products of their transformations. This area of research on natural phosphorus compounds is still little-studied, that prompted us to analyze and discuss it in our review. Moreover natural organophosphorus compounds represent interesting models for the development of new biologically active compounds, and a number of promising drugs and agrochemicals have already been obtained on their basis. The review also discusses the history of the development of ideas about the role of organophosphorus compounds and stereochemistry in the origin of life on Earth, starting from the prebiotic period, that allows us in a new way to consider this most important problem of fundamental science.

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Section: Discussionmentioning

confidence: 72%

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Kolodiazhnyi

2021

Symmetry

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“…ZGt-1 from Zara hot springs [24,25]. More than 25 species of Geobacillus have been found in thermophilic environments around the world [26].…”

Section: Molecular-based Bacterial Identificationmentioning

confidence: 99%

Antimicrobial peptide coding gene of thermophilic bacteria isolated from crater hot spring in mountains around West Java

Rachmawati¹,

Asarina²,

Kennardi³

et al. 2022

J App Biol Biotech

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Antimicrobial peptides (AMPs) are ribosomal synthesized peptides produced by microorganisms, including thermophilic bacteria isolated from hot springs. The protein has a broad spectrum against Gram-positive and Gramnegative bacteria, making it a candidate for alternative antibiotics. This study aims to identify and characterize antimicrobial peptide coding genes of thermophilic bacteria isolated from Mount Kamojang and Tangkuban Perahu crater hot springs in West Java. Six samples of crater water were collected from different locations around Mount Kamojang and Tangkuban Perahu. All six isolates were identified using 16S rRNA gene sequencing and were identified as Geobacillus sp. The antagonist test of all isolates against Streptococcus mutans was carried out using a disk test, and it was seen that there was an inhibition zone formation in the culture of all strains. The largest inhibition zone was formed in the culture of Geobacillus strain TM6Sp1 which was 7.96 mm. The identification of AMP encoding genes was carried out by entering the identified genome sequence of samples into the BAGELA4 web server, and the NCBI database was used for sequence analysis and alignment. The results showed that all of the samples have the same alignment lanthipeptide Class A, which has a 100% similarity to the lantibiotic precursor. This indicates that thermophilic bacteria isolated from crater hot springs in the mountains surrounding West Java have antimicrobial activity against S. mutans due to their ability to produce AMPs of lanthipeptide Class A with an amplicon size of 230 base pairs.

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Antibacterial peptides from thermophilic bacteria

Abstract: Abstract-

Cited by 2 publications

References 78 publications

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Phosphorus Compounds of Natural Origin: Prebiotic, Stereochemistry, Application

Antimicrobial peptide coding gene of thermophilic bacteria isolated from crater hot spring in mountains around West Java

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