Antibacterial Organic Acids in Chronic Urinary Tract Infection

Zangwill, Donald P.; Porter, P.; Kaitz, Alan L.; Cotran, Ramzi S.; Bodel, Phyllis; Kass, Edward H.

doi:10.1001/archinte.1962.03620230247034

Cited by 11 publications

(1 citation statement)

References 16 publications

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“…T H E defence mechanisms which operate in the urinary tract against bacterial infections have been intensively investigated over the last decades. A slime mucous which prevents adherence (Parsons and Mulholland, 1978), mechanical expulsion (Norden, et al, 1968), low pH (Zangwill et al, 1962) and urea (Kaye, 1968;Hadas et al, 1977) have all been found protective against bacteria. But such agents, however effective, serve more to prevent infections than to cure them and comparatively little is known about the antimicrobial mechanisms which come into play once an infection has been established.…”

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confidence: 99%

Comparative histology of the mouse bladder following initial infection and re‐infection with Escherichia coli

Sivan

Griffel

Medalia

et al. 1982

The Journal of Pathology

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The present study continues our investigation of the bladder antimicrobial mechanisms following bacterial infection. Since the process of spontaneous clearance of bacteria (E. coli) from the mouse bladder is greatly accelerated upon re-infection, a histopathological comparison was made of initially infected (II) versus re-infected (RI) mice. It was reconfirmed that the spontaneous clearance upon re-infection is indeed much faster than after the initial infection. There were morphological differences between these two courses of infection, as well as in the localization and composition of the inflammatory response. Thus cellular infiltration was more evident in the epithelium of the II mice, whereas the RI animals displayed increased cellular exudation in the lamina propria. It was also found that the dominant cell in the II mouse is the granulocyte and in the RI mouse--lymphocytes, macrophages and plasma cells. This last finding is suggestive of a local immunological process. The overall results are consistent with the notion that a local immune response develops in the infected bladder and participates in the enhanced clearance in RI animals.

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confidence: 99%