Antibacterial nanocomposite hydrogels for superior biomedical applications: a Facile eco-friendly approach

Abstract

In this scientific paper, we report a facile and eco-friendly fabrication of antibacterial nanocomposite hydrogels of Au-core Ag-shell nanoparticles, embedded within Carbopol® 980 NF/Noveon® AA-1 polycarbophil acrylic acid polymeric matrix. The aim of the study was to investigate whether these nanocomposite hydrogels have the potential to be used for bacterial inactivation applications. The key feature was that, unlike the use of chemical reductants, auxiliary stabilizers and specialized expensive equipment, the Au-core Ag-shell nanoparticles ($15 AE 3 nm) were synthesized utilizing aqueous mint leaf extracts. The developed hydrogels were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy/energy-dispersive spectroscopy and thermogravimetric analysis. Swelling studies were performed in phosphate buffered saline (pH 7.4) solution. A sustained antibacterial study against E. coli (GÀ) and B. subtilis (G+) showed their excellent antibacterial efficiency, which suggested that the developed hydrogels are potential candidates for a wide range of biomedical applications.

Preparation and characterization of poly(ethylene glycol) stabilized nano silver particles by a mechanochemical assisted ball mill process

“…4,23,39,40 Nutrient agar medium was prepared by mixing peptone (5.0 g), beef extract (3.0 g) and sodium chloride (NaCl) (5.0 g) in a1000 mL double distilled water and the pH was adjusted to 7.0. Finally, agar (15.0 g) was added to the solution.…”

“…50 Furthermore, according to various literatures and the standard antibacterial test "SNV 195920-1992", 51,52 specimens showing more than 1 mm microbial zone inhibition can be considered as good antibacterial agents. 4,23,51 Hence, the PEG stabilized nano silver particles synthesized from ball mill process can be considered as excellent antibacterial agents and has been proved to, effectively, work on the inactivation of the two bacteria tested.…”

“…20,21 Moreover, by using this process, plenty of nanomaterials can be synthesized at ambient temperature, resulting in the absence of residues and with good control of particle size. 5,22,23 procedure. 20,[24][25][26] However, according to literature, there has been limited reports for the synthesis of nano sized silver particles by this process.…”

Nano zinc oxide–sodium alginate antibacterial cellulose fibres

“…In recent years, metal nanoparticles were extensively used as antibacterial agents towards many pathogens Jayaramudu, Raghavendra, Varaprasad, Sadiku, Ramam, et al, 2013;Raghavendra, Jayaramudu, Varaprasad, Mohan Reddy, & Raju, 2015). Among the various metal nanoparticles, silver nanoparticles were extensively studied because of their potential anti-bacterial properties (Kolya, Pal, Pandey, & Tripathy, 2015).…”

Development of microbial protective Kolliphor‐based nanocomposite hydrogels

“…Furthermore, swollen hydrogels were treated with dual inorganic metallic aqueous solutions and subsequently with a mint solution via the bioprocess, as clarified in section “Synthesis of dual inorganic nanocomposite hydrogels.” The swelling ratio ( S g/g ) of the hydrogel developed and their dual nanocomposite hydrogels were calculated using eq. below: where H s and H d denote the weight of the swollen hydrogel at equilibrium and the weight of the pure hydrogels, respectively.…”