Antibacterial kaolinite/urea/chlorhexidine nanocomposites: Experiment and molecular modelling

Holešová, Sylva; Valášková, Marta; Hlaváč, Dominik; Madejová, Jana; Samlíková, Magda; Tokarský, Jonáš; Pazdziora, Erich

doi:10.1016/j.apsusc.2014.04.008

Cited by 35 publications

(11 citation statements)

References 49 publications

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“…The recorded spectra were subjected to a comparative analysis which demonstrated the presence of vibrational bands characteristic for the functional groups occurring in the analyzed molecules ( Table 2 and Table 3 ). The absorption bands obtained for CHX-acetate and CIP-HCl ( Table 2 and Table 3 ) are in good agreement with previous literature [ 20 , 24 , 25 , 27 , 28 ] and [ 22 , 26 , 34 ], respectively.…”

Section: Resultssupporting

confidence: 91%

“…Nuclear magnetic resonance (NMR) spectroscopy and Fourier transform infrared spectroscopy (FTIR) are the commonly used methods for the confirmation of synthesis and structural characterization of a novel chemical framework [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The spectroscopic studies were used: (i) For the characterization of metal-complexes [ 17 , 18 , 19 , 20 , 21 , 22 , 24 , 32 , 33 ] such as metalloantibiotics [ 21 , 22 ], including metallofluoroquinolones [ 18 , 19 , 22 , 26 , 33 ] and metal complexes with chlorhexidine [ 20 , 24 ], (ii) for the analysis of the decomposition of metal-complexes [ 20 ], (iii) for the characterization of inclusion compounds [ 25 ], composites/mineral composites [ 27 , 28 , 31 , 32 ] and (iv) for the examination of interactions between the components [ 23 ]. Infrared (IR) spectroscopic method, especially the Attenuated Total Reflectance (ATR) technique and NMR spectroscopic measurements were often applied to confirm the coordination of the ligands to metal ions and to find out the possible coordination sites in the metallo-organic structures [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

et al. 2021

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Bacterial strains become resistant to almost all classes of antibiotics, which makes it necessary to look for new substitutes. The non-absorbable ciprofloxacin–biguanide bismuth complex, used locally, may be a good alternative to a conventional therapy. The purpose of this study was to study the structure of the proposed ciprofloxacin (CIP) -bismuth(III)—chlorhexidine (CHX) composite (CIP-Bi-CHX). The spectroscopic techniques such as UV-VIS (ultraviolet-visible) spectroscopy, FTIR (Fourier-transform infrared) spectroscopy and NMR (Nuclear Magnetic Resonance) spectroscopy were used for structure characterization of the hybrid compound. The performed analysis confirmed the presence of the two active components—CIP and CHX and revealed the possible coordination sites of the ligands with bismuth ion in the metallo-organic structure. Spectroscopic study showed that the complexation between Bi(III) and CIP occurs through the carboxylate and ketone groups of the quinolone ring, while CHX combines with the central ion via the biguanide moieties.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

et al. 2021

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“…The stretching vibration of the imine group appears at 1641 cm −1 [18,19]. Absorption at 1415 cm −1 belongs to the C=C stretching vibration of an aromatic ring [20].…”

Section: Resultsmentioning

confidence: 99%

Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate

et al. 2019

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Novel biomedical composites, based on organically modified vermiculite and montmorillonite with deposited Ca-deficient hydroxyapatite (CDH), were prepared. The monoionic sodium forms of vermiculite and montmorillonite were intercalated with chlorhexidine diacetate (CA). The surfaces of organoclays were used for the precipitation of Ca-deficient hydroxyapatite. The composites with Ca-deficient hydroxyapatite showed very good antibacterial effects, similar to the antimicrobial activity of pure organoclay samples. Better antibacterial activity was shown in the organically modified montmorillonite sample with Ca-deficient hydroxyapatite compared with the vermiculite composite, but, in the case of Staphylococcus aureus, both composites showed the same minimum inhibitory concentration (MIC) value. The antimicrobial effect of composites against bacteria and fungi increased with the time of exposure. The structural characterization of all the prepared materials, performed using X-ray diffraction and FT infrared spectroscopy analysis, detected no changes in the original clay or CDH during the intercalation or precipitation process, therefore we expect the strength of the compounds to be in the original power.

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“…8) to evaluate possible interactions during the granulation and tableting process which might have resulted from the low melting point of P407. CHD displayed peaks at 3325 and 3119 cm −1 (asymmetric and symmetric NH stretching vibrations), 2938 and 2886 cm −1 (asymmetric and symmetric CH stretching), 1624 cm −1 (CN stretching vibration of imine group), 1522,1483 cm −1 (NH bending vibration of secondary amine and imine groups), 1406 cm −1 (CC stretching vibrations of aromatic rings), 1290 and 1245 cm −1 CN stretching, 819 cm −1 (out of plane vibration of the aromatic ring and the CCl) group’s spectra at 718 cm −1 (Holešová et al, 2014, and Yang et al, 2007). The characteristic peaks of HPMC are at 3445 cm −1 (OH stretching) and 2897 cm −1 (CH stretching), 1375 cm −1 (asymmetric CH 3 bending vibration), 1049 cm −1 (C—O asymmetric stretching vibration) and 942 cm −1 (C—O symmetric stretching vibration (Ding et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

The effect of the source and the concentration of polymers on the release of chlorhexidine from mucoadhesive buccal tablets

Al-Ani

Martin

Britland

et al. 2019

Saudi Pharmaceutical Journal

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In the current work, two groups of chlorhexidine mucoadhesive buccal tablets were prepared, using either rod or irregularly-shaped spherical particles of hydroxypropyl methylcellulose and different ratios of poloxamer 407 (P407). The tablets were designed to release the drug over two hours. Their physicochemical properties and drug release profiles were investigated. The impact on dry granulation, the ex-vivo mucoadhesion, the swelling index, the morphology of swollen tablets and the drug release kinetic were investigated. Drug-polymers chemical interaction was studied using Fourier Transforms Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC). Due to different particle shapes, the preparation of dry granules required a 40 KN force for rod-shaped particles compared to 10 KN for the irregularly-shaped spherical particles. All formulations showed at least two-hours residence time using ex-vivo mucoadhesion. Statistically, there was no significant difference in the swelling index, drug release nor its kinetic for both groups. However, the microscopical morphology of the swollen tablet and the size of the pores were affected by particle shape. Increasing the ratio of P407 to 62.5% resulted in a pronounced increase in drug release from around 60% to >90% after two hours. Following the FTIR and DSC analyses, no chemical interaction was noted apart from the steric hindrance effect of P407, which was observed even with the physical mixtures.

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Antibacterial kaolinite/urea/chlorhexidine nanocomposites: Experiment and molecular modelling

Cited by 35 publications

References 49 publications

Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect

Study of the Structure and Antimicrobial Activity of Ca-Deficient Ceramics on Chlorhexidine Nanoclay Substrate

The effect of the source and the concentration of polymers on the release of chlorhexidine from mucoadhesive buccal tablets

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