Antibacterial graphene oxide coatings on polymer substrate

Liu, Yiming; Wen, Jing; Gao, Yang; Li, Tianyang; Wang, Hong; Yan, Hong; Niu, Baolong; Guo, Ruijie

doi:10.1016/j.apsusc.2017.12.006

Cited by 79 publications

(32 citation statements)

References 36 publications

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“…Similar surface topographies were obtained by our group by dip or spray coating silicone films, obtaining exposed platelets and aggregates or creased structures when using either GNP-M5 or GNP-M5ox [50]. Flat coatings without sharp edges, identical to the coatings containing GNP-M5ox obtained here were also reported by others using GO [20]. Thampi et al also observed wrinkled topography when spraying GO onto electrospun polycarbonate urethane (PCU) membranes [74].…”

Section: Pu/gnp Coatingssupporting

confidence: 88%

“…Other strategies are being investigated, focusing on conferring anti-adhesive and/or bactericidal properties through surface modification of the medical-grade polyurethane (PU)-a thermoplastic elastomer from which most catheters are made of [9,10]. Strategies include physical and chemical modifications such as incorporation or coatings with antibiotics or antiseptics [11][12][13], topography modification with micropatterns [14], functionalization or coating with antimicrobial peptides (AMPs) [15] and antimicrobial nanomaterials, such as silver nanoparticles (Ag NPs) [16], titanium oxide (TiO 2 ) NPs [17], carbon nanotubes (CNT) [18], bioactive compounds [19], and graphene oxide (GO) [20]. Approaches that depend on eluting bactericidal agents have many drawbacks, namely the limitation of the amount loaded, difficulty in controlling the release rate and the concentration of the released agents during the application period [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Exposure of Smaller and Oxidized Graphene on Polyurethane Surface Improves its Antimicrobial Performance

et al. 2020

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Catheter-related infections are a common worldwide health problem, highlighting the need for antimicrobial catheters. Here, antibacterial potential of graphene nanoplatelets (GNP) incorporated in the commonly used polymer for catheter manufacture—polyurethane (PU)—is investigated. Two strategies are explored: melt-blending, producing a composite, and dip coating, where a composite layer is deposited on top of PU. GNP with different lateral sizes and oxidation degrees—GNP-M5, GNP-M15, GNP-M5ox, GNP-M15ox—are applied in both strategies, and the antimicrobial potential towards Staphylococcus epidermidis of GNP dispersions and GNP-containing PU evaluated. As dispersions, oxidized and smaller GNP powders (GNP-M5ox) inhibit 74% bacteria growth at 128 µg/mL. As surfaces, GNP exposure strongly impacts their antimicrobial profile: GNP absence at the surface of composites yields no significant effects on bacteria, while by varying GNP: PU ratio and GNP concentration, coatings enhance GNP exposure, depicting an antimicrobial profile. Oxidized GNP-containing coatings induce higher antibacterial effect than non-oxidized forms, particularly with smaller GNPox, where a homogeneous layer of fused platelets is formed on PU, leading to 70% reduction in bacterial adhesion and 70% bacterial death. This pioneering work unravels how to turn a polymer clinically used to produce catheters into an antimicrobial surface, crucial to reducing risk of infection associated with catheterization.

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Section: Pu/gnp Coatingssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Exposure of Smaller and Oxidized Graphene on Polyurethane Surface Improves its Antimicrobial Performance

et al. 2020

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“…In approximately 27.8% of cases, no antibacterial effect was observed, while in approximately 66.6% of cases a bacteriostatic effect was shown. The morphology, GO size, concentration, exposure time, incubation protocol, and microorganism type are properties that affect the interaction between GO and bacteria [99][100][101]. Many studies have verified the antibacterial efficacy of GO in the form of freestanding paper, nanosheets, or nanowalls.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

Plachá

Jampílek

2019

Nanomaterials

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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“…aureus bacteria. [ 159 ] GO Metallic films, such as Zn, Ni, Sn, and steel E . coli (G-) It is also found that such activities are directly correlated to the electrical conductivity of the GO-metal systems; the higher the conductivity the better is the antibacterial activity.…”

Section: Antibacterial Activity Of Graphene Family Materialsmentioning

confidence: 99%

Graphene Family Materials in Bone Tissue Regeneration: Perspectives and Challenges

2018

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We have witnessed abundant breakthroughs in research on the bio-applications of graphene family materials in current years. Owing to their nanoscale size, large specific surface area, photoluminescence properties, and antibacterial activity, graphene family materials possess huge potential for bone tissue engineering, drug/gene delivery, and biological sensing/imaging applications. In this review, we retrospect recent progress and achievements in graphene research, as well as critically analyze and discuss the bio-safety and feasibility of various biomedical applications of graphene family materials for bone tissue regeneration.

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Antibacterial graphene oxide coatings on polymer substrate

Cited by 79 publications

References 36 publications

Exposure of Smaller and Oxidized Graphene on Polyurethane Surface Improves its Antimicrobial Performance

Exposure of Smaller and Oxidized Graphene on Polyurethane Surface Improves its Antimicrobial Performance

Graphenic Materials for Biomedical Applications

Graphene Family Materials in Bone Tissue Regeneration: Perspectives and Challenges

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