Antibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repens

Rajendran, Sanjeevan; Robertson, Luke P.; Kosgahakumbura, Lakmini; Fernando, Chathurika; Göransson, Ulf; Wang, Helen; Hettiarachchi, Chamari; Gunasekera, Sunithi

doi:10.1016/j.fitote.2023.105496

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…An endophytic fungus, Xylaria feejeensis , was derived from the medicinal plant Geophila repens in Sri Lanka. Integrated acids, derived from fungal metabolites, have strong antibacterial activity and are a potential resource of antibiotics [ 89 ]. Saikosaponin d (SSd) is an important medicinal component of the medicinal plant Bupleurum scorzonerifolium Willd.…”

Section: Medicinal Components Produced By Endophytes In Medicinal Plantsmentioning

confidence: 99%

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

Wang

Zhang

Hao

et al. 2023

Life

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With the increasing demand for medicinal plants and the increasing shortage of resources, improving the quality and yield of medicinal plants and making more effective use of medicinal plants has become an urgent problem to be solved. During the growth of medicinal plants, various adversities can lead to nutrient loss and yield decline. Using traditional chemical pesticides to control the stress resistance of plants will cause serious pollution to the environment and even endanger human health. Therefore, it is necessary to find suitable pesticide substitutes from natural ingredients. As an important part of the microecology of medicinal plants, endophytes can promote the growth of medicinal plants, improve the stress tolerance of hosts, and promote the accumulation of active components of hosts. Endophytes have a more positive and direct impact on the host and can metabolize rich medicinal ingredients, so researchers pay attention to them. This paper reviews the research in the past five years, aiming to provide ideas for improving the quality of medicinal plants, developing more microbial resources, exploring more medicinal natural products, and providing help for the development of research on medicinal plants and endophytes.

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Section: Medicinal Components Produced By Endophytes In Medicinal Plantsmentioning

confidence: 99%

Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts

Wang

Zhang

Hao

et al. 2023

Life

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“…The bioactive secondary metabolites of endophytic fungi in plants have diverse structures, such as alkaloids, terpenoids, sterols, anthraquinones, and other compounds. , These compounds hold substantial potential for discovering novel antibacterial drugs with efficient and safe profiles. , However, the growth and metabolism regulation mechanisms of endophytic fungi are complex, and the screening and preservation techniques for high-yield strains are still insufficient . Additionally, the use of bioactive secondary metabolites obtained from endophytic fungi in industrial production is challenging owing to their poor stability and low yield, hindering the development and application of natural products as pesticides.…”

Section: Introductionmentioning

confidence: 99%

“…The bioactive secondary metabolites of endophytic fungi in plants have diverse structures, such as alkaloids, terpenoids, sterols, anthraquinones, and other compounds. 10,11 These compounds hold substantial potential for discovering novel antibacterial drugs with efficient and safe profiles. 12,13 However, the growth and metabolism regulation mechanisms of endophytic fungi are complex, and the screening and preservation techniques for high-yield strains are still insufficient.…”

Section: ■ Introductionmentioning

confidence: 99%

Design, Synthesis, Antibacterial Activity, and Mechanism of Novel Mesoionic Compounds Based on Natural Pyrazole Isolated from an Endophytic Fungus Colletotrichum gloeosporioides

Cui

Zhang

et al. 2023

J. Agric. Food Chem.

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Xanthomonas oryzae pv. oryzicola (Xoo) is a type of bacteria that causes bacterial leaf blight disease in rice plants. This disease is substantially harmful, and the current prevention and control measures are facing challenges. This study has investigated the effectiveness of the control activity that the endophytic fungus NS7 fermented from Dendrobium candidum possessed against Xoo. Twenty-eight novel mesoionic compounds were designed and synthesized based on the natural compound D. These compounds displayed moderate to excellent anti-Xoo activity in vitro. Notably, compound 24 exhibited prominent anti-Xoo activity in vitro with an EC 50 value of 40.3 mg/L, which was better than that of the positive control thiodiazole copper (TC)(71.2 mg/L) and the lead compound D (108.1 mg/L). In vivo pot experiments on Xoo showed that compound 24 exhibited protective and curative activities of 39.4 and 30.4%, respectively, which were better than those of TC (35.7 and 28.8%, respectively). Further, a preliminary mechanism study indicated that compound 24 could enhance the activity of defense enzymes to improve the ability for anti-Xoo. Meanwhile, compound 24 could also regulate the carbon fixation in photosynthetic organisms, which might be related to the enhanced immune function of rice. This study offers a new strategy for discovering antibacterial agents based on natural products.

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