Antibacterial electrospun chitosan/poly(vinyl alcohol) nanofibers containing silver nitrate and titanium dioxide

Son, Bokgi; Yeom, Bong-Yeol; Song, Sang Hoon; Lee, Chang‐Soo; Hwang, Taek Sung

doi:10.1002/app.29233

Cited by 107 publications

(60 citation statements)

References 19 publications

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“…Thus, many researchers observed that the decrease of fiber diameters when electrospinning voltages increased (36,37). Similarly, we observed that attenuated ruptures of the charged jet at lower voltages were advantageous for fabricating micron-size microspheres.…”

Section: Resultssupporting

confidence: 68%

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

et al. 2013

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Abstract. Electrospinning was employed to fabricate chitosan microspheres by a single-step encapsulation of proteins without organic solvents. Chitosan in acetic acid was electrospun toward a grounded sodium carbonate solution at various electric potential and feeding rates. Electrospun microspheres became insoluble and solidified in the sodium carbonate solution by neutralization of chitosan acetate. When the freeze-dried microspheres were examined by scanning electron microscopy, the small particle size was obtained at higher voltages. This is explained by the chitosan droplet size at the electrospinning needle was clearly controllable by the electric potential. The recovery yield of chitosan microspheres was dependent on the concentration of chitosan solution due to the viscosity is the major factor affecting formation of chitosan droplet during curling of the electrospinning jets. For protein encapsulation, fluorescently labeled bovine serum albumin (BSA) was codissolved with chitosan in the solution and electrospun. At higher concentration of sodium carbonate solution and longer solidification time in the solution, the encapsulation efficiency of the protein was confirmed to be significantly high. The high encapsulation efficiency was achievable by instant solidification of microspheres and electrostatic interactions between chitosan and BSA. Release profiles of BSA from the microspheres showed that the protein release was faster in acidic solution due to dissolution of chitosan. Reversed-phase chromatography of the released fractions confirmed that exposure of BSA to acidic solution during the electrospinning did not result in structural changes of the encapsulated protein.

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Section: Resultssupporting

confidence: 68%

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

et al. 2013

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“…Other nanofibers electrospun of blends of chitosan and inorganic nanoparticles are not discussed in detail here, such as titanium dioxide (TiO 2 ) nanoparticles/chitosan/PVA electrosun nanofibers exhibiting antibacterial activities against Staphylococcus aureus and Escherichia coli [99], palladium nanoparticles/chitosan grafting acrylic copolymer (PdNPs/ CS-g-AA) blend electrospun nanofibrous catalyst applied to catalyze alpha-octene hydrogenation in normal temperature and pressure [100], etc. The combination of the characteristics of the inorganic nanoparticles and the features of chitosan nanofibers could lead to more products with unique properties that can fit special needs.…”

Section: Electrospinning Of Blends Of Chitosan and Inorganic Nanopartmentioning

confidence: 99%

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Sun¹,

Li²

2011

Express Polym. Lett.

215

101

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Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

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“…the coaxial electrospinning provides a versatile method to encapsulate immobilized antibacterial agents in the core-shell micro/nanofibers. The antibacterial mechanism of this new kind of core-shell nanofibers may be different from the mechanism of Ag-doped antibacterial nanofibers [22,23]. One reason is that the PySMPU like PUPy53 and PUPyMDI35 contains large fraction of BINA unit which have an amido group in !…”

Section: Characterizationmentioning

confidence: 93%

Coaxial electrospun polyurethane core-shell nanofibers for shape memory and antibacterial nanomaterials

Zhuo¹,

Hu²,

Chen³

2011

Express Polym. Lett.

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Abstract.A novel kind of shape memory polyurethane (SMPU) nanofibers with core-shell nanostructure is fabricated using coaxial electrospinning. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) results show that nanofibers with core-shell structure or bead-on-string structure can be electrospun successfully from the core solution of polycaprolactone based SMPU (CLSMPU) and shell solution of pyridine containing polyurethane (PySMPU). In addition to the excellent shape memory effect with good shape fixity, excellent antibacterial activity against both gramnegative bacteria and gram-positive bacteria are achieved in the CLSMPU-PySMPU core-shell nanofiber. Finally, it is proposed that the antibacterial mechanism should be resulted from the PySMPU shell materials containing amido group in ! position and the high surface area per unit mass of nanofibers. Thus, the CLSMPU-PySMPU core shell nanofibers can be used as both shape memory nanomaterials and antibacterial nanomaterials.

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Antibacterial electrospun chitosan/poly(vinyl alcohol) nanofibers containing silver nitrate and titanium dioxide

Cited by 107 publications

References 19 publications

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Coaxial electrospun polyurethane core-shell nanofibers for shape memory and antibacterial nanomaterials

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