Antibacterial Efficacy of MTAD Final Rinse and Two Percent Chlorhexidine Gel Medication in Teeth with Apical Periodontitis: A Randomized Double-blinded Clinical Trial

Malkhassian, Gevik; Manzur, Aldo; Legner, M.; Fillery, Edward D.; Manek, Sheela; Basrani, Bettina; Friedman, Shimon

doi:10.1016/j.joen.2009.08.003

Cited by 54 publications

(44 citation statements)

References 35 publications

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“…Unpleasant taste and odor . However, its activity is pH dependent and it is toxic to human periodontal ligament (PDL) cells 4 . The use of plants and plant products as medicines could be traced as far back as the beginning of human civilization.…”

Section: Introductionmentioning

confidence: 99%

Antifungal efficacy of Azadirachta indica (neem) - An in vitro study

Raghavendra¹,

Balsaraf²

2014

Braz. J. Oral Sci.

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Aim: To evaluate antimicrobial ability of neem leaf extract, 3% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX) against Candida albicans. Methods: Neem leaf extract was prepared by using absolute ethanol with fresh neem leaves, filtering the extract through muslin cloth, coarse residue and filter paper. Cultures of C. albicans were maintained on Brain Heart Infusion broth and Agar. The antimicrobial efficacy was checked using the Agar Diffusion and the zones of inhibition were measured. The results were statistically analysed using ANOVA test. Inter-group comparison was checked using Kruskal Wallis ANOVA and Mann Whitney tests (a=0.05). Results: There was statistically significant difference between the zones of inhibition seen with 3% NaOCl and Neem extract with 2% CHX (p<0.05). There was no significant difference observed between Neem extract and 3% NaOCl. Conclusions: Efficacy of Neem extract is comparable to 3% NaOCl against C. albicans and it is significantly better than 2% CHX.

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Section: Introductionmentioning

confidence: 99%

Antifungal efficacy of Azadirachta indica (neem) - An in vitro study

Raghavendra¹,

Balsaraf²

2014

Braz. J. Oral Sci.

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“…Komorowski et al [ 45 ] suggested that a 5-min application of CHX did not induce substantivity, so the dentin should be treated with CHX for 7 days. However, when Paquette et al [ 63 ] and Malkhassian et al [ 55 ] in their in vivo studies medicated the canals with either liquid or gel forms of CHX for 1 week, neither of them could achieve total disinfection. Therefore, residual antimicrobial effi cacy of CHX in vivo still remains to be demonstrated.…”

Section: Substantivitymentioning

confidence: 99%

Update of Endodontic Irrigating Solutions

Basrani¹,

Malkhassian²

2015

Endodontic Irrigation

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Successful root canal therapy depends on thorough debridement of pulpal tissue, dentin debris, and infective microorganisms. Currently, it is impossible to predictably eradicate intraradicular infection with mechanical instrumentation alone. Therefore, irrigants are required to be used as an important addition in the disinfection process. This chapter analyzes the main irrigating solutions used during the endodontic treatment and their actions and interactions among them. Explanation of their mechanism of action and effect on dentin structure and on biofi lm is also described. A clinical protocol is proposed at the end of the chapter.The goal of endodontic treatment is to prevent or cure apical periodontitis. Apical periodontitis is an infl ammatory process in the periradicular tissues caused by microorganisms in the infected root canal [ 84 ]. It is well known that shaping, cleaning, and obturating the root canal system provide the strategy for successful treatment. The principle to reach favorable outcomes in endodontic infection management requires the recognition of the problem and the removal of the etiological factors.In endodontic disinfection, there are two main challenges which are important to be recognized the anatomical challenge and the microbiological challenge [ 42 ].The anatomical challenge can be divided into complexity of the root canal system, dentin structure, and dentin constituents. Anatomical Complexities (also see Chap. 2 ):Root canal is an enclosed complex space with intricate confi gurations and apical constriction it is important to mention here that more than 35 % of the root canal surface is left untouched by conventional instrumentation [ 35 , 64 ] (Fig. 5.1 ). Also, common instrumentation techniques accumulate debris in isthmus areas. Paque et al. showed explained that when rotary fi les are used in canal with a round cross section, the dentine particles that are cut from the canal wall are car-

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“…A compound has been developed with combined chelating and antibacterial properties (13). MTAD (BioPure MTAD; Dentsply Tulsa Dental Specialties, Tulsa, OK) is a mixture of doxycycline, citric acid, and Tween.…”

Section: Mtadmentioning

confidence: 99%

Root Canal Irrigants in Horizon: A Review

2016

IJSR

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Local wound debridement in the diseased pulp space is the main step in root canal treatment to prevent the tooth from being a source of infection. Successful root canal therapy is always based on the combination of proper instrumentation, irrigation and obturation of the root canal. Of these three essential steps of root canal therapy, irrigation of the root canal is the most important technique which aids in the healing of the periapical tissues. The root canal is shaped under constant irrigation to remove the inflamed and necrotic tissue, microbes, biofilms and other debris from the root canal space. There is no single irrigating solution that can alone cover all of the functions required from an irrigant. Optimal irrigation is based on the combined use of two or several irrigating solutions, in a proper sequence, to predictably obtain the goals of safe and effective irrigation. This article highlights various irrigants, ideal requirements of irrigants and newer irrigants used for irrigation.

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Antibacterial Efficacy of MTAD Final Rinse and Two Percent Chlorhexidine Gel Medication in Teeth with Apical Periodontitis: A Randomized Double-blinded Clinical Trial

Cited by 54 publications

References 35 publications

Antifungal efficacy of Azadirachta indica (neem) - An in vitro study

Antifungal efficacy of Azadirachta indica (neem) - An in vitro study

Update of Endodontic Irrigating Solutions

Root Canal Irrigants in Horizon: A Review

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