Bacteria have long been recognized as the primary etiological factor in the development of pulp and periapical lesions. Successful root canal therapy depends on thorough debridement of pulpal tissue, dentin debris, and infective microorganisms. Currently, it is impossible to eradicate intraradicular infection with mechanical instrumentation alone. Therefore, irrigants are required to complete this task. In this article, the different actions and interactions of the most commonly used irrigants are discussed. The aim of this review is to analyze the relevant literature on root canal irrigants.
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