Antibacterial Efficacy of Acacia modesta Wall Miswak Against Dental Pathogen

Asghar, Rehana; Ahmad, Mushtaq; Zafar, Muhammad Mubashar; Akram, Abida; Hassan, Maqbool

doi:10.3923/pjbs.2003.2024.2025

Cited by 10 publications

(12 citation statements)

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“…As compared to the standard drug, the highly significant activity of Acacia modesta and other medicinal plants extracts was recorded by Napar et al 15 against S. aureus, B. subtilis and E. coli. The stem extracts of A. modesta with five bacterial strains showed that this specific part of the plant has profound antibacterial activity, and same results were noted by 17 . The methanolic extract of A. modesta displayed maximum zone of inhibition of 8 mm against E. faecalis, S. aureus, and S. typhi, and did not show any activity against B. subtalis and P. aeruginosa 18 .…”

Section: Discussionsupporting

confidence: 73%

“…Noticeably, among the plant extracts tested, the bark of J. regia and T. aphylla showed the higher antimicrobial potential that might be due the accumulation of flavonoids content in the bark as resported earleir 16,17 . Like that, the bark of J. regia and T. aphylla has been particularly demontrated previously to have a higher antimicrobial potential as compared to other parts 18,19 .…”

Section: Discussionmentioning

confidence: 96%

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In-vitro Evaluation of Anti-Bacterial, Anti-biofilm and Cytotoxic Activity of Naturally Inspired Juglans regia, Tamarix aphylla L., and Acacia modesta with Medicinal Potentialities

Khalid¹,

Bilal²,

Munir³

et al. 2020

J Pure Appl Microbiol

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The usefulness of medicinal plants has evoked increasing research interests to combat antimicrobial resistance. The current work reports on the in vitro bioactive activities, i.e., antibacterial, anti-biofilm and cytotoxicity evaluation of three medicinal plants. Extracts from different plant parts (leaves, stems, and root barks) were obtained using different solvents, such as methanol, ethanol, and water. The methanolic extracts of bark of Juglans regia and Tamarix aphylla L., whereas the stem of Acacia modesta (Wall.) exhibited the highest antibacterial activity. The maximum zone of inhibition, i.e., 21.8±0.76 mm was observed against H. influenza for a methanolic extract of J. regia. Similarly, the maximum inhibition zones of ethanolic extract of T. aphylla L. against A. baumannii and methanolic extract of A. modesta against S. aureus were recorded. Notably, a higher anti-biofilm potential of the methanolic extract of J. regia was recorded against six pathogenic strains. Finally, the cytotoxicity of plants extracts was evaluated by testing the hemolytic activity against human erythrocytes, that displayed the negligible percent lysis of RBCs. In conclusion, the results of this study provided information related to the possible use of some medicinal plants in the treatment of microbial related ailments.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 96%

In-vitro Evaluation of Anti-Bacterial, Anti-biofilm and Cytotoxic Activity of Naturally Inspired Juglans regia, Tamarix aphylla L., and Acacia modesta with Medicinal Potentialities

Khalid¹,

Bilal²,

Munir³

et al. 2020

J Pure Appl Microbiol

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“…Because of curative properties, gum was used for back pain and sex. Plant use was also seen in treatment of cough [11][12][13][14][15] .…”

Section: Ethno-medicinal Usesmentioning

confidence: 99%

Pharmacological and phytochemical studies on Acacia modesta Wall; A review

Sarwar¹

2016

J Phytopharmacol

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The use of plants with therapeutic properties is as ancient as human civilization. Acacia modesta belongs to family Fabaceae and is a deciduous tree which has medium or small size. Traditionally, it has been used to treat leprosy, wounds, dysentery, venereal diseases, cough, body weakness, bacterial infections and backache. Many pharmacological activities have been reported viz. antibacterial, antifungal, anti-hyperglycemic, analgesic, anti-inflammatory, anti-platelet, anti-termite, antioxidant, brine shrimp cytotoxicity, haemagglutination, insecticidal, phytotoxic and spasmolytic. While various flavonoids, terpenoids, alkaloids, tannins, non-protein amino acids, fixed oils and cyclitols have been isolated from this plant. This review is an attempt to provide adequate information on ethno-medicinal uses, general morphology, pharmacological and phytochemical properties of the plant.

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“…Gum has been used for back pain and sex because of the curative properties. Plant use was also seen in cough treatment (Asghar et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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Natural Plants are broadly used in treating inflammatory disorders. The current study focused on evaluating the hepato-protective and anti-inflammatory potential of A. modesta in MnCL 2 induced hepatotoxicity and liver inflammation. The MnCl2 induce 6.0mg/kg was given for 30 days (p.o) to induced hepatotoxicity and liver inflammation. The ethanolic extract of A. modesta were given orally at the dose of 100mg/kg/day. The in vivo inflammatory manganese induced hepatotoxic model is used for evaluating the acacia heap to-protective effect. Gas chromatography-mass spectrometry analyses were performed to find out compounds responsible for anti-inflammatory properties. Results showed that administration of ethanolic extract (100 mg/kg), altogether diminished inflammation of the liver, expanded liver capacity, oxidative stress and his to-pathological outcomes in the current study compared with disease rats. The beneficial outcomes of A. modesta extract were observed on liver inflammation.

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Antibacterial Efficacy of Acacia modesta Wall Miswak Against Dental Pathogen

Cited by 10 publications

References 0 publications

In-vitro Evaluation of Anti-Bacterial, Anti-biofilm and Cytotoxic Activity of Naturally Inspired Juglans regia, Tamarix aphylla L., and Acacia modesta with Medicinal Potentialities

In-vitro Evaluation of Anti-Bacterial, Anti-biofilm and Cytotoxic Activity of Naturally Inspired Juglans regia, Tamarix aphylla L., and Acacia modesta with Medicinal Potentialities

Pharmacological and phytochemical studies on Acacia modesta Wall; A review

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