Antibacterial effects of vulgarone B from Artemisia iwayomogi alone and in combination with oxacillin

Chung, Eun Young; Byun, Y.; Shin, Eun Joo; Chung, Ha Sook; Lee, Yeon Hee; Shin, Seungwon

doi:10.1007/s12272-009-2208-8

Cited by 27 publications

(15 citation statements)

References 21 publications

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“…For the studies of structure-activity relationships, it was postulated that the α,β-unsaturated carbonyl group is essential for the antifungal activity of vulgarone B. This compound, vulgarone B, has also been reported in the essential oil from A. iwayomogi as an antibacterial constituent [84]. The antibacterial activities of vulgarone B have been demonstrated against some antibiotic-susceptible and -resistant human pathogens, and the antibiotic mechanism involved might be related to DNA cleavage.…”

Section: Anti-infective Effects Of Essential Oils From the Artemismentioning

confidence: 99%

The Artemisia L. Genus: A Review of Bioactive Essential Oils

et al. 2012

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Numerous members of the Anthemideae tribe are important as cut flowers and ornamental crops, as well as being medicinal and aromatic plants, many of which produce essential oils used in folk and modern medicine and in the cosmetics and pharmaceutical industry. Essential oils generally have a broad spectrum of bioactivity, owing to the presence of several active ingredients that work through various modes of action. Due to their mode of extraction, mostly by distillation from aromatic plants, they contain a variety of volatile molecules such as terpenes, phenol-derived aromatic and aliphatic components. The large genus Artemisia L., from the tribe Anthemideae, comprises important medicinal plants which are currently the subject of phytochemical attention due to their biological and chemical diversity. Artemisia species, widespread throughout the world, are one of the most popular plants in Chinese traditional preparations and are frequently used for the treatment of diseases such as malaria, hepatitis, cancer, inflammation and infections by fungi, bacteria and viruses. Extensive studies of the chemical components of Artemisia have led to the identification of many compounds as well as essentials oils. This review summarizes some of the main reports on the chemistry and anti-infective activities of Artemisia. Li. essential oils from the data in the recent literature (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011).

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Section: Anti-infective Effects Of Essential Oils From the Artemismentioning

confidence: 99%

The Artemisia L. Genus: A Review of Bioactive Essential Oils

et al. 2012

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“…Furthermore, the combination with oxacillin resulted in synergism against antibiotic-resistant Staphylococcus aureus . The antibiotic mechanism may involve bacterial DNA cleavage [ 87 ].…”

Section: Biological Activities Of Sesquiterpene Lactonesmentioning

confidence: 99%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

146

118

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Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

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“…6, is a sesquiterpene ketone abundant in A. iwayomogi, to which the antimicrobial properties of this herb are attributed [31]. This compound has also been isolated as the active constituent of A. douglasiana [32].…”

Section: Sesquiterpene Lactones From Artemisia Genusmentioning

confidence: 99%

“…Chung et al [31] investigated the antibacterial activities of vulgarone B, Fig. 6, a component of A. iwayomogi, against some antibiotic susceptible and resistant human pathogens.…”

Section: Antimalarial and Other Anti-infective Activitiesmentioning

confidence: 99%