Antibacterial Effects of Some Antiseptics and Disinfectants

Ak, Saha; Haque, Mohammad Rashedul; Karmaker, Susmita; Mohanta, MK

doi:10.3329/jles.v3i0.7440

Cited by 25 publications

(22 citation statements)

References 11 publications

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“…In this case, one would expect an elevated toxicity in the mammals exposed to MA (re: MA-cyanurate or MA-cyanurate-urate crystals). At the same time, Klebsiella species are susceptible to FA; thus, during the concurrent exposures, it is possible that the FA hindered MA conversion in the gut (Saha et al 2009). If this was the case here, there were less MA-derived toxicants available to impart hematologic/immunologic effects in these hosts.…”

Section: Discussionmentioning

confidence: 96%

Hemato-immunologic impact of subchronic exposure to melamine and/or formaldehyde in mice

Abd‐Elhakim

Mohamed

2016

Journal of Immunotoxicology

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The aim of the present study was to explore the potential hematotoxic and immunotoxic effects of melamine (MA) in the absence and presence of formaldehyde (FA) in mice. Forty adult Swiss mice were equally allocated into four groups and daily treated with water, MA (50 mg/kg), FA (25 mg/kg), and MA þ FA respectively via feeding needle for 60 consecutive days. Hematological status was evaluated using erythrogram and leukogram profiling. Innate immune functions were assessed by measuring white blood cells lysozyme and phagocytic activities. Serum immunoglobulin levels were evaluated as indicators of humoral immunity. In addition, histologic and immunohistochemical evaluations of splenic tissues were performed. The results indicated that either MA or FA treatment resulted in significant decreases in RBCs, Hb, MCHC, total WBC, lymphocyte, and basophile levels as well as in WBCs phagocytosis and lysozyme activity. In contrast, MCV, PCV%, and reticulocyte levels were significantly increased in these hosts. The total IgM level was significantly reduced in the MA-only-exposed mice but markedly increased in the FA-only-treated ones. A significant decrease in serum IgG levels was detected following either MA or FA treatment. The combined exposure to MA and FA, compared to levels of either toxicant alone, was revealed to evoke a significant improvement in Hb, PCV%, MCV, MCHC, neutrophil, eosinophil, total IgM level, and lysozyme activity; however these values did not reach that of the controls. Furthermore, compared to control mice, both MA-only-and FA-only-treated mice showed a strong distribution of CD4 þ and CD8 þ cells in their spleens, while a moderate presence of the former cells was obvious at their co-exposure. Taken together, these findings revealed that exposure to MA or FA resulted in significant alterations in hemato-immune parameters at variable degrees while a co-exposure resulted in the mitigation of most effects of either toxicant alone. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 96%

Hemato-immunologic impact of subchronic exposure to melamine and/or formaldehyde in mice

Abd‐Elhakim

Mohamed

2016

Journal of Immunotoxicology

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“…It has been documented that some antiseptics and disinfectants are rather less effective to S. aureus strains that carry a plasmid carrying genes encoding resistance. 27 The study of Saha et al 28 showed similar results in which the effect of six types of antiseptics and disinfectants, namely Dettol (chloroxylenol), Savlon (chlorhexidine gluconate and cetrimide), iodine, phenyl, formalin, and hydrogen peroxide (H 2 O 2 ) was studied on S. aureus, Salmonella typhi, Shigella dysenteriae, Klebsiella species, and E. coli. S. aureus showed the maximum resistance to disinfectants tested.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of Efficacy of Different Denture Disinfectants on Biofilms Formed on Acrylic Resin

Bhathal

Kukreja²,

Kukreja³

2018

Dental Journal of Advance Studies

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Purpose Health professionals, especially in dentistry, are involved at high risk of microbial cross contamination. There are many studies that reported the risk of cross-contamination in prosthetic laboratories. Although much importance has been given to infection control practices, such as the barrier technique, sterilization, and disinfection of the dental office and instruments, less emphasis has been given for the disinfection of dentures. The dentures in mouth are prosthetic medical devices that create an appropriate habitat for both pathogenic and nonpathogenic organisms to nurture. To avoid cross-contamination, denture disinfection is mandatory. This study evaluated the efficacy of four denture disinfectants on four most common organisms found in denture biofilm at two different time intervals. Materials and Methods Three hundred twenty denture base acrylic resin specimens were fabricated by means of wax patterns with dimensions diameter 15 mm × 4 mm. The contamination of samples was done by the four microorganisms taken in study that were Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, and Escherichia coli. The contaminated samples were disinfected by immersion procedure in four disinfectants that were sodium hypochlorite, glutaraldehyde, peracetic acid, and chloroxylenol. Results Sodium hypochlorite was the best disinfectant resulting in complete elimination of microorganisms in 5 minutes immersion time. Glutaraldehyde and chloroxylenol were also effective against microorganisms. Minimum 10 minutes immersion time was required to completely eliminate the microorganisms. Peracetic acid was least effective of all showing the least reduction in microbial growth. Among the organisms, S. aureus showed the maximum resistance to disinfection, and C. albicans was the least resistant. AbstractKeywords ► disinfectants ► infection control ► microorganisms ► acrylic resin Dent J Adv Stud 2018;6:20-27

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“…(chlorhexidine gluconate, 0.3% w/v and cetrimide B.P, 3% w/v), ethyl alcohol (70%), hand gel rub type 1 (ethanol and triclosan), hand gel rub type 2 (ethanol 70% v/v), hand gel rub type 3 (alcohol denat), liquid antiseptic soap types (1, 2 and 3) and plain liquid soap (non-antimicrobial). The sensitivity of the aforementioned agents was evaluated according to Saha et al [14]. Briefly, tryptic soy broth tubes were inoculated with the tested strains and incubated at 37°C for 24 hours.…”

Section: Sensitivity Of Selected Mrsa Isolates To Some Hand Cleansingmentioning

confidence: 99%

Occurrence and Zoonotic Importance of Methicillin-Resistant Staphylococcus aureus in raw Milk and Some Dairy Products at Ismailia City, Egypt

Fadel

2015

Zagazig Veterinary Journal

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This study was undertaken to determine the occurrence and the zoonotic importance of methicillin resistant Staphylococcus aureus (MRSA) in raw milk of sheep, goats and buffaloes, some dairy products and dairy workers at Ismailia City, Egypt. A total of 150 samples were collected randomly and cultured on Baird Parker agar and CHROMagar MRSA. Culturing on Baird Parker agar, the results revealed that 46.7 % of raw goat milk, 40% of raw sheep milk, 40% of raw buffaloes' milk, 80% of yogurt, 36.7% of ice cream, 63.3% of Kareish cheese and 63.3% of human swabs' samples were contaminated by coagulase positive Staphylococcus aureus. The isolation rates of MRSA on CHROMagar MRSA in relation to the number of the examined samples and the number of S. aureus isolates were (33.3 and 71.4%), (20 and 50%), (13.3 and 33.3%), (40 and 50%), (13.3 and 36.4%), (33.3 and 52.6%) and (13.3 and 21.1%) from the examined milk samples (goat, sheep, and buffaloes), yogurt, ice cream, Kareish cheese and human swabs' samples, respectively. PCR results showed that all the isolates that were classified as MRSA on CHROMagar contained mecA gene. Results of the disk diffusion test revealed that the resistance rates of MRSA strains to penicillin, gentamycin, vancomycin, clindamycin, amikacin, erythromycin and oxacillin were 91.2%, 67.6%, 14.7%, 94.1%, 91.2%, 82.4% and 100%, respectively. The effectiveness of some hand cleansing agents against the selected MRSA isolates was assessed. It was found that hand gel rub based on alcohol and triclosan together was the most effective agent. The findings of the present study necessitate exerting more efforts for effective control of MRSA in dairy products.

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Antibacterial Effects of Some Antiseptics and Disinfectants

Cited by 25 publications

References 11 publications

Hemato-immunologic impact of subchronic exposure to melamine and/or formaldehyde in mice

Hemato-immunologic impact of subchronic exposure to melamine and/or formaldehyde in mice

Evaluation of Efficacy of Different Denture Disinfectants on Biofilms Formed on Acrylic Resin

Occurrence and Zoonotic Importance of Methicillin-Resistant Staphylococcus aureus in raw Milk and Some Dairy Products at Ismailia City, Egypt

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