Antibacterial Effects of Nanoparticles of Metals

Леонтьев, В. К.; Кузнецов, Денис; Frolov, G. A.; Pogorelskiy, Ivan Petrovich; Latuta, N.V.; Krasenkov, Yakov Nikolaevich

doi:10.18821/1728-2802-2017-21-6-304-307

Cited by 7 publications

(6 citation statements)

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“…Эффективность действия наночастиц металлов во многом зависит от принадлежности микроорганизмов к клиническим полирезистентным или антибиотикочувствительным музейным культурам -наночастицы меди, а также серебра и золота наиболее активны в отношении полирезистентных клинических штаммов бактерий (наличие различий на уровне значимости 0,05, n = 72). Полученный результат подтверждают аналогичные исследования на других микроорганизмах, авторы которых отмечают, что максимальный антибактериальный эффект наночастиц металлов достигается при воздействии на клинические штаммы бактерий с множественной лекарственной устойчивостью [6,10,11,13,14].…”

Section: антибактериальная активность достигается в результате использования наночастиц металлов в разных концентрациях (рис 2)unclassified

“…Быстрое формирование устойчивости микроорганизмов к современным антибактериальным препаратам требует поиска все новых, альтернативных методов терапии [5,9,13], одним из которых может стать использование наночастиц металлов. Наночастицы экологически не опасны, обладают бактерицидной активностью [6,10,15], а также имеют низкую себестоимость, что играет немаловажную роль при решении вопроса их выбора.…”

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“…Известно, что они могут оказывать как бактериостатический, так и бактерицидный эффект, действовать как интрацеллюлярно, так и экстрацеллюлярно. Согласно некоторым теориям, наночастицы могут способствовать ингибированию ферментов дыхательной цепи, тем самым разобщая процессы окисления и окислительного фосфорилирования; взаимодействовать с нуклеотидами, нарушая стабильность ДНК; взаимодействовать с пептидогликанами клеточной стенки, блокируя способность передавать кислород; или выступать в роли катализатора, способствуя окислению протоплазмы растворенным в воде кислородом [6,13]. Механизм действия зависит как от вида микроорганизмов, на который оказывается воздействие, так и от типа наночастиц, их концентрации, размера, а также от способа их получения.…”

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Metal nanoparticle antibacterial effect оn antibiotic-resistant strains of bacteria

Удегова

Гильдеева

Рукосуева

et al. 2021

Russian Journal of Infection and Immunity

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The rapid formation of microbial resistance to modern antibacterial drugs requires to search for new, alternative therapies. It is known that some organisms, such as plants, algae, fungi, are able to convert inorganic metal ions into metal nanoparticles due to the recovery process carried out by proteins, sugars and metabolites contained in the tissues and cells of these organisms. At the same time, many plants (e.g., plantain, yarrow, wormwood, turmeric long, calendula, marsh bagulnik, etc.) and metals (copper, silver, gold, zinc, etc.) themselves have antibacterial properties, so that metal nanoparticles obtained by biological method, or via “Green” synthesis method, from extracts of such plants can become a current alternative to many modern antibacterial drugs. The antibacterial mechanism of action of nanoparticles depends on the type of microorganisms affected, as well as on the type of nanoparticles, their concentration, size, and how they are obtained. Based on this, the study of the antibacterial effect of nanoparticles is one of the promising directions of solving the problem of microbial antibiotic resistance. There was examined antibacterial effect of metal nanoparticles containing silver, copper and gold obtained by biological method from the salts of AgNO3, CuSO4, H[AuCl4] metals, respectively, and the extract of the plant — turmeric long (lat. Curcuma longa) — related to the following bacteria strain collection: E. coli (ATCC 25922), S. aureus (ATCC 25923), MRSA (ATCC 38591) and polyresistant clinical strains isolated from patients of the Regional clinical hospital (Krasnoyarsk) — К. рneumoniae, strain 104, P. аeruginosa, strain 40, P. аeruginosa, strain 215, А. baumannii, strain 210, А. baumannii, strain 211. Study allowed to identify the minimum suppressive concentration of nanoparticles by the method of serial dilutions (MUK 4.2.1890-04) with azurin dye. It was proved that metal nanoparticles exhibit different antibacterial efficacy depending on the type of nanometals used and bacterial cultures. Copper nanoparticles have the highest antibacterial activity, and gold nanoparticles have the lowest. The most marked antibacterial effect was observed against clinical polyresistant strains. Metal nanoparticles can become an alternative to the currently known antibacterial drugs, but despite the high efficiency of nanoparticles against polyresistant to antibacterial drugs microorganisms in vitro, it is necessary to take into account their possible toxic effect on live tissues, which requires further study in experiments in vivo.

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Metal nanoparticle antibacterial effect оn antibiotic-resistant strains of bacteria

Удегова

Гильдеева

Рукосуева

et al. 2021

Russian Journal of Infection and Immunity

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“…Исследования проводились на микробной куль туре зубного налета и смешанной культуре, выделенной из зубодесневых карманов стоматологических пациентов. Все растворы показали высокую пролонгированную в течение 19 дней бактерицидную активность в разведениях от цельного раствора до 1-20 мг/л [6]. Преимущества использования наночастиц металлов и оксидов металлов связано, прежде всего, с тем, что механизм их действия в отношении бактерий отличается от стандартных механизмов действия антибиотиков, что позволяет преодолеть МЛУ [74].…”

Section: Introductionunclassified

Аntibacterial inorganic agents: efficiency of using multicomponent systems

Мелешко¹,

Афиногенова²,

Афиногенов³

et al. 2020

Russian Journal of Infection and Immunity

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Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents exerting a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans and allowing to avoid developing microbial resistance. Here we briefly review general mechanisms and the main NP factors affecting their antibacterial activity. Special attention is paid development of new-generation antimicrobial agents displaying augmented long-term bactericidal activity and low toxicity. We also describe examples of synthesizing double and triple nanocomposites based on the following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2 , etc. including metal and nonmetal doped nanocomposites (e.g. with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and exert synergistic effects. For instance, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by ∼100 % by formation of triple nanocomposites ZnO–MnO2–Cu2O or ZnO–Ag2O–Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. We also highlight the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and long-term antibacterial activity. All of the nanocomposites and their combinations described have a pronounced long-term antimicrobial effect including that one against antibiotic-resistant microbial strains. They are able to prevent formation of microbial biofilms on biotic and abiotic surfaces, exhibit low toxicity to eukaryotic cells, demonstrate anti-inflammatory and wound-healing properties in contained with polymers (sodium alginate, collagen, polyvinylpyrrolidone etc.). The use of nanoscale systems can solve several important practical problems simultaneously by preserving long-term antimicrobial activities while reducing the number of constituents, generation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.

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“…At a porosity of 3-8%, the thermal conductivity of magnesium oxide exceeds 30 W/(m•K) and tends to increase with decreasing temperature. Biocompatibility of Mg (maximum permissible concentration 50 mg/m 3 ) is the highest for metals [2].A number of studies have shown that nano-structured coatings have bactericidal properties, presumably due to the effect because of local surface plasmon resonance [4][5][6]. To determine the conditions for realizing this effect, we developed a laser method.…”

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confidence: 99%