Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance

Gaidukevich, S K; Mikulovich, Yu. L.; Smirnova, Tatiana G.; Andreevskaya, Sofya; Сорокоумова, Г. М.; Chernousova, L. N.; Селищева, А. А.; Швец, В. И.

doi:10.1007/s10517-016-3247-z

Cited by 17 publications

(10 citation statements)

References 5 publications

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“…There are many visualization procedures exist for imaging of nanoliposomes, For instance to detect particles bigger than 290 nm and impurity with larger particles, a phase contrast optical microscope is an appropriate choice (Gaidukevich et al 2016) and a polarizing microscope is suitable for revealing lamellarity of liposomes (Tanifum et al 2016). Scanning electron microscopy, freeze-fracture, and negative staining are common techniques applied to characterize nanoliposome structures.…”

Section: Visualization Techniquesmentioning

confidence: 99%

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Panahi

Farshbaf

Mohammadhosseini

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

192

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Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

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Section: Visualization Techniquesmentioning

confidence: 99%

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Panahi

Farshbaf

Mohammadhosseini

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

192

View full text Add to dashboard Cite

show abstract

“…It was also, described before that liposome-encapsulated drugs can kill microbes faster, before microbial mutations can develop. Moreover, this method has been reported [46] that, the incorporation of the antibiotic drug levofloxacin into liposomes improved the antimycobacterial activity to kill Mtb strains resistant to the drug levofloxacin. Several drug delivery systems, among them the non-ionic surfactant vesicles (NIVs), have the capability to encapsulate both hydrophobic and hydrophilic drugs for direct delivery to the site of infection [47].…”

Section: Resultsmentioning

confidence: 99%

Minor Groove Binders MGBs: A Mini Review

2021

JCBSC

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Distamycin and Netropsin are the two naturally occurring polyamide heterocycles and they belong to a group of heterocyclic compounds called Lexitropsins. These compounds exhibit their activity by binding to the minor groove of the DNA. Minor groove binders MGBs, in general, have several biological activities such as anticancer, antibiotics, and anti-parasitic qualities. Over the years several research groups have modified these compounds by replacing the pyrrole groups by other heterocyclic compounds and many other modifications have been employed to both the tail group and the head group. These changes gave rise to new compounds with different biological activities.

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“…33 A liposomal complex containing the phospholipid cardiolipin co-entrapped with levofloxacin was formulated by Gaidukevich et al to suppress the growth of Mycobacterium tuberculosis and reduce the minimum inhibitory concentration of cardiolipin (33.5 μM) and levofloxacin up to 2 μg ml −1 . 34 Antimicrobial activities of herbal extracts with lysozyme were evaluated against two Gram-positive (B. subtilis and M. luteus) and two Gram-negative (E. coli and S. marcescens) bacteria by Matouskova et al 35 The integration of selective antimicrobial peptides such as S-thanatin onto liposomes with encapsulated levofloxacin via a lipid PEG linker was recently reported by Fan et al 36 ( Fig. 3B).…”

Section: Liposomesmentioning

confidence: 96%

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

Jijie

Barras

Teodorescu

et al. 2017

Mol. Syst. Des. Eng.

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Abstract.Numerous antimicrobial drugs have been developed and commercialized to kill and inhibit the growth of pathogenic microbes. The therapeutic efficiency of these drugs has however become often inadequate for the treatment of microbial infections, the reasons being multiple. Oral administration results often in only partial absorption and up to 50% of the active compound can be excreted in the urine. Furthermore, antibiotic therapy is also frequently accompanied by gastrointestinal complications, including vomiting, nausea and diarrhea. From a therapeutic point of view, the low solubility of antibiotics in lipid membranes presents a limitation for rapid and efficient treatment of infections. The preferred route for the delivery of antimicrobial drugs is the oral one; oral formulations capable of extending the duration of drug delivery and minimizing side effects have received much attention. The combination of antimicrobial agents with nanomaterials has been seen as a particularly promising strategy to overcome these limitations. Particulate formulations have proven their efficiency in achieving better pharmacokinetic profiles and improving the bio availability of several antibiotics. Antibiotic modified particles have shown their capability to protect some of the antimicrobial drugs from stomach acid and first-pass metabolisms in the gastrointestinal tract. Likewise, particle formulations can increase the circulation times of a drug and the local concentration gradient across absorptive cells. The present review describes the current status of different types of antibiotic loaded nano-systems. Key principles such as antibiotic loading, the release mechanism and the mode of action involved in pathogen killing or inhibition will be discussed in more detail. It is hoped that the general knowledge obtained here will help in the generation of advanced nanomaterials loaded with antimicrobials agents.Post-print 2

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Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance

Cited by 17 publications

References 5 publications

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Minor Groove Binders MGBs: A Mini Review

Advancements on the molecular design of nanoantibiotics: current level of development and future challenges

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