Abstract:Distamycin and Netropsin are the two naturally occurring polyamide heterocycles and they belong to a group of heterocyclic compounds called Lexitropsins. These compounds exhibit their activity by binding to the minor groove of the DNA. Minor groove binders MGBs, in general, have several biological activities such as anticancer, antibiotics, and anti-parasitic qualities. Over the years several research groups have modified these compounds by replacing the pyrrole groups by other heterocyclic compounds and many … Show more
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