Antibacterial effects and ibuprofen release potential using chitosan microspheres loaded with silver nanoparticles

Pereira, Anna Karla dos Santos; Reis, Davi Texeira; Barbosa, Keleen M.; Scheidt, Gessiel Newton; Costa, Luelc Souza da; Santos, Lucas Samuel Soares dos

doi:10.1016/j.carres.2019.107891

Cited by 40 publications

(20 citation statements)

References 44 publications

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“…To accomplish the objective of sustained release of LSP, it was incorporated in chitosan microparticulate matrix using different cross-linkers in varied proportions by employing emulsion cross linking method. The cross-linkers selected for the preparation of chitosan microspheres were covalently cross-linking agents (glutaraldehyde, formaldehyde, and vanillin); ionically cross-linking agents (citric acid and sulphuric acid) and epichlorohydrin crosslinker which link through carbon atoms to the polymer [6][7][8][9][10].…”

Section: Conclusion the Outcome Of In Vitro Release And Other Charac-mentioning

confidence: 99%

Formulation and Characterization of Losartan Loaded Chitosan Microspheres: Effect of Crosslinking Agents

2020

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Objective The present investigation entailed determination of effect of diverse cross-linking agents on Losartan Potassium loaded chitosan microspheres. The emulsion cross-linking method was employed to formulate the microspheres with an endeavour to achieve maximum sustained effect. Methods The FTIR studies revealed absence of any interaction between Losartan and chitosan. The emulsion cross linking method was accomplished in three steps encompassing formation of an aqueous and oily phase, emulsification and cross-linking. A total of eighteen Losartan formulations were developed using six different cross-linkers at three varying level were screened for optimum parameters. The in vitro drug release parameters of optimum formulations (LC3, LE3, LF3, LG3, LS3 and LV3) containing citric acid, epichlorohydrin, formaldehyde, glutaraldehyde, suphuric acid and vanillin as cross-linkers were assessed to determine the sustained effect. Results The values of evaluated parameters including percent yield (94.67%), average particle size (51.19 µm), drug content (44.38 mg) and entrapment efficiency (88.77%) connoted LG3 as the best formulation. Additionally, the values of relative measure of skewness (β1=0.01 and γ1=0.10) and platykurtic (β2=1.26) size distribution were least for LG3 with spherical shape and smooth surface as revealed by SEM studies. Conclusion The outcome of in vitro release and other characterizations of microspheres explicitly revealed glutaraldehyde as the best cross-linker amongst the cross-linkers used herewith. The maximum sustained effect (lasting over a period of 24 h) accompanied with higher MDT and t50% with lower%DE and Q14h values thus corroborated the objective of attaining sustained release of Losartan.

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Section: Conclusion the Outcome Of In Vitro Release And Other Charac-mentioning

confidence: 99%

Formulation and Characterization of Losartan Loaded Chitosan Microspheres: Effect of Crosslinking Agents

2020

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“…However, most species of Leptosphaeriaceae lack tef1 -α sequence data and other protein-coding markers, and some known species were sequenced using different tef1 -α primer pairs. Thus, the phylogenetic analysis was constructed based on combined LSU, SSU, and ITS sequence data as provided in Dayarathne et al (2015) ; Wanasinghe et al (2016) , Tennakoon et al (2017) , and this study. Nevertheless, we provide tef1 -α sequence data for P. artemisiae , P. artemisiae , and S. artemisiae to facilitate the future identification of species.…”

Section: Discussionmentioning

confidence: 99%

“…Species of Leptosphaeriaceae are widely distributed on various hosts and different regions ( Dayarathne et al, 2015 ; Tennakoon et al, 2017 ; Phookamsak et al, 2019 ). They can be saprobic, hemibiotropic, pathogenic, or parasitic occurring on stems and leaves of herbaceous or woody plants in terrestrial and aquatic habitats ( Alves et al, 2013 ; Hyde et al, 2013 ; Jones et al, 2015 ; Wanasinghe et al, 2016 ; Doilom et al, 2018 ). The early classification of taxa in Leptosphaeriaceae lacked DNA sequence data from ex-type strains.…”

Section: Introductionmentioning

confidence: 99%

The Plant Family Asteraceae Is a Cache for Novel Fungal Diversity: Novel Species and Genera With Remarkable Ascospores in Leptosphaeriaceae

et al. 2021

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In a cursory survey of fungi on Asteraceae in Yunnan Province, China, we report fungal species belonging to the family Leptosphaeriaceae (Pleosporales, Dothideomycetes). Two novel species have remarkable ascospores that are unusual for sexual ascomycetes. Multilocus phylogeny of large subunit, small subunit, and internal transcribed spacer sequence data showed one to be a novel genus, while the other is a new species. Praeclarispora artemisiae gen. et sp. nov. is introduced and is typical of Leptosphaeriaceae, but has unusual fusiform, versicolor ascospores with a brown median cell. Sphaerellopsis artemisiae sp. nov. has scolecosporous ascospores with deeply constricted septa that split into two parts, which resembles S. isthmospora but differs by ascospore dimension and molecular data. In addition, Plenodomus artemisiae is reported as a new collection from dead stems of Artemisia argyi in Qujing City. Plenodomus sinensis is reported as a new host record from Ageratina adenophora. All taxa are illustrated and described based on evidence of taxonomy and phylogeny.

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“…However, the half-life of IBU is only 2 h [ 8 ]. Thus, an effective method for sustained release is necessary to utilize IBU for wound healing [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

Liu

Wang

Cheng

et al. 2021

Bioactive Materials

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The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge. The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation. Herein, we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen (PCEI) and multifunctional PCEI-based F127-ε-polypeptide-alginic (FEA) dressing (FEA-PCEI) for accelerating wound healing and hair follicle neogenesis. PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization. The FEA-PCEI dressing showed the temperature-response gelation, injectability, robust antibacterial activity, light-damage-resistant, homeostasis ability, and good cytocompatibility. The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability, reduce the scar formation, and promote the hair follicle neogenesis. This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.

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Antibacterial effects and ibuprofen release potential using chitosan microspheres loaded with silver nanoparticles

Cited by 40 publications

References 44 publications

Formulation and Characterization of Losartan Loaded Chitosan Microspheres: Effect of Crosslinking Agents

Formulation and Characterization of Losartan Loaded Chitosan Microspheres: Effect of Crosslinking Agents

The Plant Family Asteraceae Is a Cache for Novel Fungal Diversity: Novel Species and Genera With Remarkable Ascospores in Leptosphaeriaceae

Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

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