Antibacterial, DNA interaction and superoxide dismutase activity of drug based copper(II) coordination compounds

Copper(II) complexes with new fluoroquinolones: Synthesis, structure, spectroscopic and theoretical study, DNA damage, cytotoxicity and antiviral activity

“…The observed results indicate a direct interaction between DNA and complex molecules which may occur through intercalation of the planar phenanthroline moiety of complexes. The intercalating binding mode of mixed complexes containing a fluoroquinolone and nitrogen-donor heterocyclic ligand has been confirmed by the reported CT-DNA solution viscosity measurements [21,23,79,80]. As it has been reported previously, the intercalation of planar ligand into the DNA base pairs causes the direct cleavage of DNA without ROS production [81].…”

DNA interaction, free radical scavenging andin‐vitroantibacterial activity of drug‐based copper(II) complexes

“…[38] The K b value of I and II is higher than that for most of the previously reported complexes of type [Cu(cpf)(A n )Cl]. [28] These spectral characteristics are consistent with a mode of interaction that involves a stacking interaction between the complex and the base pairs of DNA, which means that the complexes can intercalate into the double helix structure of DNA.…”

“…The antibacterial activity of all the complexes is even higher than the antibacterial activity of complexes, which were previously reported by our group. [28] It has also been suggested [29,30] that the ligands with nitrogen donor systems might inhibit enzyme production, since the enzymes that require these groups for their activity appear to be especially susceptible to deactivation by the metal ions upon chelation. Chelation reduces the polarity [29,30] of the metal ion, mainly because of the partial sharing of its positive charge with the donor groups and possibly the π -electron delocalization within the whole chelate ring system thus formed during coordination.…”

“…Compounds exhibited SOD-like activity at biological pH with the IC 50 values in the range 0.5-1.25 µM, which is very similar for the complexes of same type reported previously by our group. [28] The superoxide scavenging data are shown in Table 4.…”

Synthesis and characterization of cobalt(II), nickel(II) and copper(II)-based potential photosensitizers: Evaluation of their DNA binding profile, cleavage and photocytotoxicity

“…3). Although optical photophysical probes usually offer essential information about the binding modes of complexes to DNA, they are lacking of certain evidences to support an intercalative binding model [96][97][98][99].…”