Antibacterial Cyclopeptide Alkaloids from the Bark of Condalia buxifolia.

Abstract

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Triterpenoids from Gouania ulmifolia

“…However, there are no reports of previous phytochemical studies and ethno-medicinal uses of this plant to date. In a continuation of the search for new bioactive substances from representatives of the Rhamnaceae family in Rio Grande do Sul (Brazil) [5], [6], [7], [8], [9], [10], we studied the chemical constituents of the aerial parts of G. ulmifolia. In this work, the isolation and characterization of two new pentacyclic triterpenes (1 and 2) of the D 20(29) -lupene series, and five known compounds: lupeol (3), b-sitosterol (4), betulinic acid (5), alphytolic acid (6) and bsitosterol glucoside (7) are reported.…”

Cyclopeptide alkaloids

“…Scutianine-B (1) was only active against E. coli, while adouetine-Y¢ (8), and scutianines-C (2), -F (56) and -M (22) and scutianene-D (30) were found to be inactive against all the strains tested. This finding suggests that the stereochemistry and the presence of b-phenylserine residue in the structure of the alkaloids have an influence on bioactivity (Morel et al 2002(Morel et al , 2005. Loloatin B (60) inhibited the growth of methicillin resistant S. aureus, vancomycin resistant Enterococcus sp., and penicillin resistant Streptococcus pneumoniae with MICs of 1-2 lg/ml (Gerard et al 1996).…”

Stereoselective Hydrogenation ofCCBonds: Application to Drug and Natural Product Synthesis

“…231 Adamczyk and co-workers set out to develop a straightforward access to enantioenriched (S)-(À)-acromelobinic 232 and (S)-(À)-acromelobic 233 acids to achieve elaboration of asymmetric hydrogenation of dehydroamino acid derivatives 145 and 147 (Scheme 29.10). 234 The dehydroamino acid derivative 145 was hydrogenated in the pres- Cyclopeptide alkaloids 235,236 belong to a class of natural products widely distributed among plants of the Rhamnaceae family, 237 but their occurrence has also been confirmed in representatives of Celastraceae, 238 antifungal, sedative, and antiplasmodial. 239 Both abyssenine A and murconine E were isolated from the roots and stem bark of several Zizyphus-type Rhamnaceae.…”