Cyclopeptide alkaloids

Abstract

In this review, we discuss cyclopeptide alkaloids, their plant origin, and the way of separation, spectral analysis done for structure elucidation, stereochemistry, and their biological activities. In addition, we discuss briefly the chemosystematic significance of the cyclopeptide alkaloids based on their discovery in the family Olacaceae.

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

“…1, although extract of LyC was composed of arrays of compounds, they can be generally classified into three major groups: 1) coumarins; 2) dihydrocaffeic conjugates; 3) cyclic-peptides containing tryptophan fragments, according to the UV spectra of natural products reported in literatures (EI-Seedi, Zahra, Goransson, & Verpoorte, 2007;Funayama et al, 1995;Kayser & Kolodziej, 1995;Li et al, 2014;Potterat, 2010). LC-MS/MS analysis further revealed the molecular weights and structures of compounds that showed relative high abundance in each group (Fig.…”

Nutritional and Bioactive Compounds in Mexican Lupin Beans Species: A Mini-Review

“…Furthermore, alkaloids, such as spartein, lupanin, 13-hydroxylupanine, and multifluorine, which are very abundant in wild species, have pharmacological activities in the central nervous system and a hypoglycemic effect on the pharmaceutic sector. However, it is very important that the molecules do not change when ingested, because their effect could be different, as in the alkaloid Frangufoline, a sedative cyclopeptide alkaloid that does not change in the gastric juices, so it is absorbed unchanged and performs its function [71].…”

Biomimetic Synthesis of Azole‐ and Aryl‐Peptide Alkaloids

“…Numerous cyclopeptide alkaloids containing aryl-alkyl ethers have been isolated from a host of different plant families, such as Rhamnaceae, Rubiaceae, Olacaceae, and others [56,57]. The structure of these 13-to 15-membered macrocycles features a phenyl alkyl ether with an enamide in ortho-para or ortho-meta orientation (Figure 9.8).…”