Antibacterial coumarins fromAngelica gigas roots

Abstract

Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.

Antibacterial Activity of Ethanol Extract of Betel Leaf (Piper betle L.) Against Some Food Borne Pathogens

“…The use of medicinal plants as novel antibiotics have several other advantages related to safety, availability, and minimizing the risk of side effects and addiction 1 . The World Health Organization (WHO) has adopted a major policy change in accepting that most developing nations would have to make use of more traditional medical practices for primary health care 2 .…”

Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation

“…Decursin is a major active compound found in the roots of Angelica gigas Nakai, which has been traditionally used to treat female afflictions and anemia (3,4). There are some reports about the pharmacological effects of this compound showing anti-bacterial and anti-leukemic activity, activation of protein kinase C, an and anti-angiogenic effect (3)(4)(5)(6)(7).…”

“…There are some reports about the pharmacological effects of this compound showing anti-bacterial and anti-leukemic activity, activation of protein kinase C, an and anti-angiogenic effect (3)(4)(5)(6)(7). Decursin reportedly inhibits growth and promotes apoptosis in several other cancer cells (8,9).…”

Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells

“…Many studies have examined the pharmacological properties of A. gigas Nakai such as its antibacterial, anticancer, antitumor, antioxidant, anti-inflammatory, neuroprotective, anti-dementia, inhibition of platelet aggregation, and blood coagulation activity (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Based on these pharmacological properties, efforts have been made to isolate the active constituents from this plant.…”