Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation

Kim, Wun-Jae; Lee, Se Jung; Choi, Young Deuk; Moon, Sung Joon

doi:10.3892/ijmm_00000386

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…In general, the cell cycle arrest is a prestage that induces apoptosis. Previous reports have reported that decursin acts on the cell cycle and is involved in antitumor effects in prostate cancer, bladder cancer, and colorectal cancer [ 29 , 33 ]. In this study, decursin increased the number of cells in the G0/G1 phase and decreased in the S-phase on human osteosarcoma cell lines at 24 h. Decursin also acted on cyclin D1 and CDK6 that arrests the cell cycle in G0/G1 phase.…”

Section: Discussionmentioning

confidence: 99%

A Natural Organic Compound “Decursin” Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma

Hayashi,

Shirai,

Terauchi

et al. 2023

Journal of Oncology

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Osteosarcoma is a rare malignant tumor that commonly occurs in children. Anticancer drugs, for example, cisplatin, aid in postsurgery recovery but induce side effects such as renal damage, affecting the life prognosis of patients. Decursin which is one of the bioactive components has been reported for its anti-inflammatory, antioxidant, and antitumor effects, but the effect on osteosarcoma is unexplained. In this study, the research theme was to examine the sensitizing effect of decursin and its influence on cisplatin-induced nephrotoxicity. The cell viability and half maximal inhibitory concentration (IC50), apoptosis induction, and effect on cell cycle and Akt pathways were examined. In vivo, we examine the effects of decursin on tumors and mice bodies. Additionally, the effects of the cisplatin-decursin combination were evaluated in vitro and in vivo. Decursin suppressed cell viability and induced apoptosis via the cell cycle. Decursin also inhibited the Akt pathway by suppressing the phosphorylation of Akt. It enhanced apoptosis induction and lowered cell viability in combination with cisplatin. The increasing tumor volume was suppressed in the decursin-administrated group with further suppression in combination with cisplatin compared to sole cisplatin administration. The decrease in renal function and renal epithelial cell damage caused by cisplatin was improved by the combinatorial treatment with decursin. Therefore, decursin demonstrated an antitumor effect on the osteosarcoma cells and a renal protective effect in combination with cisplatin. Therefore, decursin is a prospective therapeutic agent against osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

A Natural Organic Compound “Decursin” Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma

Hayashi,

Shirai,

Terauchi

et al. 2023

Journal of Oncology

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“…Our results support the conclusion that the fat-soluble polyphenols in MH-30 contributed to inhibition melanoma growth. There are many reports that decursin exhibits anticancer activity by inhibiting the Wnt/βcatenin pathway, inducing cell cycle arrest and apoptosis, and inhibiting VEGF-induced angiogenesis, and also by inhibiting metastasis by targeting MMP-9 activity (53)(54)(55)(56). In addition, MH-30 showed a synergistic effect in combination with cisplatin on melanoma growth inhibition in vitro.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Park

Cho

et al. 2020

In Vivo

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Background/Aim: Although cisplatin is an effective anticancer drug, its toxic effects on normal tissues limit its use. We developed a herbal formula, MH-30, with increased fat-soluble polyphenols by improving the manufacturing method of HemoHIM. In this study, we examined whether the combination of MH-30 with cisplatin exerts synergistic antitumor effect while it reduces cisplatininduced toxicities. Materials and Methods: MH-30 was produced by adding the ethanol-insoluble fraction to its extract after decocting herbs in 30% ethanol and water. We used a melanoma-bearing mice model to investigate synergistic anticancer effects. The NK cell activity and cytokine levels were measured by Cr 51-release assay and ELISA. The AST, ALT, BUN, and creatinine levels were estimated in the serum. Results: MH-30 effectively inhibited melanoma growth in vitro. Furthermore, MH-30 had a synergistic effect in combination with cisplatin on melanoma growth inhibition in vitro and in vivo. In melanoma-bearing mice, cisplatin alone decreased the activity of NK cells and the levels of IL-2 and IFN-γ, which were effectively restored by the combination of MH-30 with cisplatin. Combined treatment with MH-30 and cisplatin significantly inhibited the cisplatin-induced increase in the levels of AST, ALT, BUN, and creatinine. Conclusion: Combination of MH-30 with cisplatin may be a beneficial anticancer treatment with reduced adverse effects.

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“…Decursin is isolated from the root of Angelica Gigas, and it has been shown to mediate cancer formation, angiogenesis, and inflammation [238]. It can effectively suppress tumor growth by inducing apoptosis via G1-phase cell cycle arrest and decreasing proliferation and angiogenesis through VEGF receptor inactivation and protein kinase C activation [239][240][241][242][243][244][245][246]. Meanwhile, decursin has been demonstrated to block COX-2 expression in the inflammatory bowel disease model as well as inhibiting PI3K, ERK, and NF-κB activation in the in vitro cancer cell line studies [247][248][249][250].…”

Section: Nonsteroidal Compounds: Decursinmentioning

confidence: 99%

Potential Effects of Nutraceuticals in Retinopathy of Prematurity

Tsang

Wolf

Pompoes

et al. 2021

Life

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Retinopathy of prematurity (ROP), the most common cause of childhood blindness, is a hypoxia-induced eye disease characterized by retinal neovascularization. In the normal retina, a well-organized vascular network provides oxygen and nutrients as energy sources to maintain a normal visual function; however, it is disrupted when pathological angiogenesis is induced in ROP patients. Under hypoxia, inadequate oxygen and energy supply lead to oxidative stress and stimulate neovasculature formation as well as affecting the function of photoreceptors. In order to meet the metabolic needs in the developing retina, protection against abnormal vascular formation is one way to manage ROP. Although current treatments provide beneficial effects in reducing the severity of ROP, these invasive therapies may also induce life-long consequences such as systemic structural and functional complications as well as neurodevelopment disruption in the developing infants. Nutritional supplements for the newborns are a novel concept for restoring energy supply by protecting the retinal vasculature and may lead to better ROP management. Nutraceuticals are provided in a non-invasive manner without the developmental side effects associated with current treatments. These nutraceuticals have been investigated through various in vitro and in vivo methods and are indicated to protect retinal vasculature. Here, we reviewed and discussed how the use of these nutraceuticals may be beneficial in ROP prevention and management.

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Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation

Cited by 14 publications

References 28 publications

A Natural Organic Compound “Decursin” Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma

A Natural Organic Compound “Decursin” Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma

Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Potential Effects of Nutraceuticals in Retinopathy of Prematurity

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