Antibacterial composite coatings of MgB2 powders embedded in PVP matrix

Abstract

Three commercial powders of MgB2 were tested in vitro by MTS and LDH cytotoxicity tests on the HS27 dermal cell line. Depending on powders, the toxicity concentrations were established in the range of 8.3–33.2 µg/ml. The powder with the lowest toxicity limit was embedded into polyvinylpyrrolidone (PVP), a biocompatible and biodegradable polymer, for two different concentrations. The self-replenishing MgB2-PVP composite materials were coated on substrate materials (plastic foil of the reservoir and silicon tubes) composing a commercial urinary catheter. The influence of the PVP-reference and MgB2-PVP novel coatings on the bacterial growth of Staphylococcus aureus ATCC 25923, Enterococcus faecium DMS 13590, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, in planktonic and biofilm state was assessed in vitro at 6, 24, and 48 h of incubation time. The MgB2-PVP coatings are efficient both against planktonic microbes and microbial biofilms. Results open promising applications for the use of MgB2 in the design of anti-infective strategies for different biomedical devices and systems.

Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

“…4a, b , Nano-MgB 2 exhibited excellent antibacterial activity at a low concentration at around 12.5 μg/mL, whereas H 3 BO 3 + Mg 2+ group exhibited little or no antibacterial effect against P. aeruginosa at the same concentration. This antibacterial effect of our synthesized Nano-MgB 2 was dramatically stronger than that of commercial MgB 2 powders 37 , and was comparable to the effects of gentamicin, amikacin, ciprofloxacin, levofloxacin, and better than imipenem, meropenem, ceftazidime, cefepime, ampicillin+sulbactam, aztreonam (Supplementary Fig. 16a ).…”

Fundamentals and utilization of solid/ liquid phase boundary interactions on functional surfaces

“…Despite top-down techniques in general offer better controllability over surface roughness with higher reproducibility, bottom-up approaches are still more popular as they are cheaper, easier to apply, and offer higher scalability. Although, the advanced examples of rough surfaces for wetting-related functional applications are composites (consisting of a matrix-/support-and one or more roughening filler materials) [63,64], monolithic systems also can be prepared by topdown techniques [65], filtrate deposition [51], foam-sintering [66] or templating methods [67].…”

Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

“…MgB 2 can be prepared by a variety of methods, including spark plasma sintering (SPS) [ 26 , 27 , 28 , 29 , 30 , 31 ]. Our research group has recently reported for the first time in the scientific literature the potential for the antimicrobial applications of MgB 2 materials (powders and biodegradable coatings based on polyvinylpyrrolidone) for the clinical field and for combating the negative impact of microbial colonization in different environments, as with the biodeterioration of heritage buildings [ 26 , 32 , 33 , 34 , 35 ]. We have previously shown that the antimicrobial activity of MgB 2 powders depends on the fabrication process (e.g., MgB 2 powders produced by reactive liquid infiltration (RLI) show superior performance to commercial powders) as well as their purity, microstructure, and pH behavior in water.…”