Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications

Vaz, Juliana Miguel; Pezzoli, Daniele; Chevallier, Pascale; Campelo, Clayton Souza; Candiani, Gabriele

doi:10.2174/1381612824666180219143900

Cited by 49 publications

(34 citation statements)

References 216 publications

(245 reference statements)

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“…Still, in 1894, the German Felix Hoppe-Seyler named the compound chitosan. It was in 1950 that the chemical structure of chitosan was determined [ 14 , 15 ].…”

Section: Chitin and Chitosan Historymentioning

confidence: 99%

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Santos

Marques

Maia

et al. 2020

IJMS

264

123

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Chitosan is a cationic polymer obtained by deacetylation of chitin, found abundantly in crustacean, insect, arthropod exoskeletons, and molluscs. The process of obtaining chitin by the chemical extraction method comprises the steps of deproteinization, demineralization, and discoloration. To obtain chitosan, the deacetylation of chitin is necessary. These polymers can also be extracted through the biological extraction method involving the use of microorganisms. Chitosan has biodegradable and biocompatible properties, being applied in the pharmaceutical, cosmetic, food, biomedical, chemical, and textile industries. Chitosan and its derivatives may be used in the form of gels, beads, membranes, films, and sponges, depending on their application. Polymer blending can also be performed to improve the mechanical properties of the bioproduct. This review aims to provide the latest information on existing methods for chitin and chitosan recovery from marine waste as well as their applications.

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“…Still, in 1894, the German Felix Hoppe-Seyler named the compound chitosan. It was in 1950 that the chemical structure of chitosan was determined [ 14 , 15 ].…”

Section: Chitin and Chitosan Historymentioning

confidence: 99%

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Santos

Marques

Maia

et al. 2020

IJMS

264

123

View full text Add to dashboard Cite

show abstract

“…The development of products involving bioactive materials obtained from renewable sources is of global importance, motivating the scientific community to search for innovative products . Biomaterials include biopolymers, proteins, and nucleic acids, all of which are promising in the pharmacotherapeutic field.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanocrystals as a Sustainable Raw Material: Cytotoxicity and Applications on Healthcare Technology

Pelegrini

Ré

Oliveira

et al. 2019

Macro Materials & Eng

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Cellulose nanocrystals (CNCs) are an environmentally friendly natural material, consisting of rod‐like crystalline nanoparticles, called whiskers, or nanocrystalline cellulose. The derivation of different natural sources, aligned to their biocompatibility, biodegradability, and versatility, make them a class of fascinating materials with widespread industrial use. In addition, the cellulose species possess intriguing physicochemical and mechanical properties. This paper provides an overview of recent progress in the area of cellulosic nanocomposites, along with details of their structure and liquid crystalline behavior as nematic and cholesteric lyotropic materials. Guidance is subsequently provided for the physicochemical analysis of these materials, including X‐ray diffraction, transmission electron microscopy, optical evaluation, thermogravimetric analysis, and differential scanning calorimetry. Additionally, the functional chemical and physical properties of CNCs are correlated to the resulting nanotoxicity in in vitro and in vivo assays. This review points to relevant concerns, such as sources for the synthesis of CNCs, the nanomaterial size, and the surface chemistry, that must be overcome in order to attain safe use of CNC‐based nanomaterials. The challenging perspectives on the ongoing research are presented in order to explore the technological and industrial perspectives on the use of CNC for the generation of cost‐effective advanced nanomaterials based on cellulosic fibers.

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“…In particular, natural polymers have been of great interest, due to their inherent biological properties. Among these, chitosan has emerged as a promising material due to its various properties, including antimicrobial properties, high biocompatibility, and low immunogenicity and allergenicity . In addition, its mucoadhesive properties allow interactions with blood cells and, thus, speed up clot formation and hemostasis .…”

Section: Introductionmentioning

confidence: 99%

“…Among these, chitosan has emerged as a promising material due to its various properties, including antimicrobial properties, high biocompatibility, and low immunogenicity and allergenicity . In addition, its mucoadhesive properties allow interactions with blood cells and, thus, speed up clot formation and hemostasis . Chitosan is also widely used in biomedical applications that involve contact with the bloodstream and tissues, biodegradable medical devices, and disposable clinical apparatus.…”

Section: Introductionmentioning

confidence: 99%

Development, Validation, and Performance of Chitosan‐Based Coatings Using Catechol Coupling

Campelo

Chevallier

Loy

et al. 2019

Macromolecular Bioscience

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The use of long‐lasting polymer coatings on biodevice surfaces has been investigated to improve material–tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibility, non‐toxicity, and antimicrobial properties. One way to produce chitosan coating is by covalent grafting with catechol molecules such as dopamine, caffeic acid, and tannic acid, resulting in an attachment ten times stronger than that of simple physisorption. Caffeic acid presents an advantage over dopamine because it allows direct chitosan grafting, due to its terminal carboxylic acid group, without the need of a linking arm, as employed in the dopamine approach. In this study, the grafting of chitosan using caffeic acid, over surfaces or in solution, is compared with dopamine grafting using poly(ethylene glycol) as a linking arm. The following coating properties are observed; covering and homogeneity are assessed by X‐ray photoelectron spectroscopy and atomic force microscopy analyses, hydrophilicity with contact angle measurements, stability with aging tests, anticorrosion behavior, and coating non‐toxicity. Results show that grafting using caffeic acid/chitosan in solution over a metallic surface may be advantageous, compared to traditional dopamine coating.

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Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications

Cited by 49 publications

References 216 publications

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Cellulose Nanocrystals as a Sustainable Raw Material: Cytotoxicity and Applications on Healthcare Technology

Development, Validation, and Performance of Chitosan‐Based Coatings Using Catechol Coupling

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