Antibacterial clay against gram-negative antibiotic resistant bacteria

Zárate-Reyes, Luis; López-Pacheco, Cynthia; Nieto‐Camacho, Antonio; Palacios, Eduardo; Gómez‐Vidales, Virginia; Kaufhold, Stephan; Ufer, Kristian; Zepeda, Eduardo García; Cervini-Silva, Javiera

doi:10.1016/j.jhazmat.2017.08.078

Cited by 41 publications

(10 citation statements)

References 22 publications

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“…These studies have focused on specific ions and heavy metals, but they did not necessarily offer definitive answers for clay antimicrobial activity. For example, when these proposed mechanisms were applied to clays other than those involved in the studies (for example Fe-saponite), they yielded contradictory results (Zarate-Reyes et al, 2018). Interestingly, none of the above studies has acknowledged or sought to investigate the presence and contribution of an organic load.…”

Section: Discussion 41 Bioactivity -The Contribution Of the Inorganic Component (In Reference To Elements Ti Fe Al And B As Leachates Or mentioning

confidence: 99%

The interweaving roles of mineral and microbiome in shaping the antibacterial activity of archaeological medicinal clays

Christidis

Knapp

Venieri

et al. 2020

Journal of Ethnopharmacology

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Section: Discussion 41 Bioactivity -The Contribution Of the Inorganic Component (In Reference To Elements Ti Fe Al And B As Leachates Or mentioning

confidence: 99%

The interweaving roles of mineral and microbiome in shaping the antibacterial activity of archaeological medicinal clays

Christidis

Knapp

Venieri

et al. 2020

Journal of Ethnopharmacology

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“…Within this, clay-based topical therapies have been shown to be effective in treating skin conditions, including necrotising fasciitis, as noted above (Williams et al, 2004), open wounds (Sirousazar et al, 2011), and acne (Toombs, 2005). Detailed analysis of clays and their impact on bacterial survival has led to the suggestion that the aluminum and iron content of clays is the toxic component (i.e., what kills bacteria), probably as a result of localized release of reactive oxygen species at the bacterial surface (Morrison et al, 2016;Wang et al, 2017;Zarate-Reyes et al, 2018). The antibacterial action of clays has been further evidenced in other studies.…”

Section: The Case Of Claymentioning

confidence: 99%

The Social and Material Life of Antimicrobial Clay: Exploring Antimicrobial Resistance, Medicines' Materiality, and Medicines Optimization

Jamie

Sharples

2020

Front. Sociol.

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While sociologists have made significant theoretical contributions to the antimicrobial resistance (AMR) debate, little attention has been given to the antimicrobial products themselves. Here we advocate a significant new direction which centers on the social and material life of antimicrobials, specifically on what they are made from and how this affects their use. This focus is timely because, in the context of declining efficacy of biomedical antibiotics, diverse materials are increasingly taking center stage in research and drug discovery as potential agents for new antimicrobial treatments. Of particular significance are natural antimicrobials, such as plants, honey and clay, whose antimicrobial potential is well-documented and which are increasingly moving into mainstream antimicrobial research. Alongside this biomedical focus, we suggest that the social and material lives of these antimicrobial materials require attention to (i) highlight the ways they have been, and continue to be, used in diverse cultures globally, (ii) explore ways we might theorize these materials within wider AMR debates, and (iii) examine the impact of antimicrobials' materiality on their use by patients. This article takes the example of clay, whose antimicrobial properties are well-established and which has been used to treat wounds and gastrointestinal problems for millennia. We first locate clay as an exemplar of a wider shift toward natural products drug discovery in pharmaceutical science and antimicrobial research. We then offer a number of theoretical "ways in" for sociologists to begin making sense of clay as it comes under the western biomedical gaze. We map these conceptual lenses on to clay's physical and symbolic mobility from its use in the global south into western biomedical research and commercialization. We particularly concentrate on post-colonial theory as a means to understand clay's movement from global south to north; laboratory studies to examine its symbolic transformation to a black-boxed antimicrobial artifact; and valuation practices as a lens to capture its movement from the margins to the mainstream. We finish by reflecting on the importance of materiality in addressing optimal use of medicines and by advocating an interdisciplinary approach to AMR which positions sociology as a key contributor to AMR solutions.

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“…These mechanisms encompass the sorptive properties of minerals leading to the release of mineral-bound cytotoxic metals on the one hand [215,216]. In the case of Al release this may imply Al binding to phospholipids resulting in osmotic imbalance and cell lysis [217,218]. On the other hand, nutrients can sorb to the minerals so that nutrient availability for bacteria becomes insufficient [219].…”

Section: Medicinal Resourcesmentioning

confidence: 99%

The role of soils in provision of genetic, medicinal and biochemical resources

Thiele‐Bruhn

2021

Phil. Trans. R. Soc. B

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Intact, ‘healthy’ soils provide indispensable ecosystem services that largely depend on the biotic activity. Soil health is connected with human health, yet, knowledge of the underlying soil functioning remains incomplete. This review highlights selected services, i.e. (i) soil as a genetic resource and hotspot of biodiversity, forming the basis for providing (ii) biochemical resources and (iii) medicinal services and goods. Soils harbour an unrivalled biodiversity of organisms, especially microorganisms. Some of the abilities of autochthonous microorganisms and their relevant enzymes serve (i) to improve natural soil functions and in particular plant growth, e.g. through beneficial plant growth-promoting, symbiotic and mycorrhizal microorganisms, (ii) to act as biopesticides, (iii) to facilitate biodegradation of pollutants for soil bioremediation and (iv) to yield enzymes or chemicals for industrial use. Soils also exert direct effects on human health. Contact with soil enriches the human microbiome, affords protection against allergies and promotes emotional well-being. Medicinally relevant are soil substrates such as loams, clays and various minerals with curative effects as well as pharmaceutically active organic chemicals like antibiotics that are formed by soil microorganisms. By contrast, irritating minerals, soil dust inhalation and misguided soil ingestion may adversely affect humans. This article is part of the theme issue ‘The role of soils in delivering Nature’s Contributions to People.

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Antibacterial clay against gram-negative antibiotic resistant bacteria

Cited by 41 publications

References 22 publications

The interweaving roles of mineral and microbiome in shaping the antibacterial activity of archaeological medicinal clays

The interweaving roles of mineral and microbiome in shaping the antibacterial activity of archaeological medicinal clays

The Social and Material Life of Antimicrobial Clay: Exploring Antimicrobial Resistance, Medicines' Materiality, and Medicines Optimization

The role of soils in provision of genetic, medicinal and biochemical resources

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