Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material

Karahaliloğlu, Zeynep; Kılıçay, Ebru; Denkbaş, Emir Baki

doi:10.1080/21691401.2016.1203796

Cited by 81 publications

(34 citation statements)

References 46 publications

(43 reference statements)

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“…Development of haemostatic wound dressings that induce rapid blood clotting has been shown to be vital in preventing blood loss (Martin, ). A recent study demonstrated haemostatic activity of SF driven by electrostatic interactions, which induces binding with blood platelets, thus enhancing treatment of full‐thickness wounds (Karahaliloglu, Kilicay, & Denkbas, ). Silk‐based nanofibrous mats showed superior haemostatic activity compared with surgical cotton gauze when examined by quantifying the LDH activity of adhered platelets (Figure b; p ≤ .01).…”

Section: Resultsmentioning

confidence: 99%

Functionalized PVA –silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling

Chouhan

Janani

Chakraborty

et al. 2017

J Tissue Eng Regen Med

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Chronic cutaneous ulcers, a complex pathophysiological diabetic condition, represent a critical clinical challenge in the current diabetes mellitus pandemic. Consequently, there is a compelling need for bioactive dressings that can trigger healing processes for complete wound repair. Silk fibroin (SF), a natural protein polymer from mulberry and non-mulberry silkworms, has properties that support accelerated wound healing rate. SF from non-mulberry variety possesses additional cell-binding motifs (arginine, glycine, and aspartate), offering cell-material interactions. This study is aimed to investigate wound healing efficacy of dressings made up of various SF varieties blended with poly(vinyl alcohol) biopolymer in alloxan-induced diabetic rabbit model. The nanofibrous mats have been developed using electrospinning and functionalized with growth factors and LL-37 antimicrobial peptide for sustained delivery. Following post 14-day treatment, non-mulberry SF (NMSF)-based dressings healed the wounds faster, in comparison with their mulberry Bombyx mori SF, poly(vinyl alcohol), and control counterparts (p < .01). NMSF-based dressings also supported faster granulation tissue development, angiogenesis, and reepithelialization of wounds. Gene expression study of matrix metalloproteinases and collagen proteins affirmed higher extent of tissue remodelling during the repair process. Furthermore, there was organized extracellular matrix deposition (collagen type I, collagen type III, elastin, and reticulin) and higher wound breaking strength in NMSF compared with other groups after 4 weeks. These results validated the potential of NMSF-based bioactive dressings to regulate extracellular matrix deposition leading to faster and complete repair of chronic diabetic cutaneous wounds.

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Section: Resultsmentioning

confidence: 99%

Functionalized PVA –silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling

Chouhan

Janani

Chakraborty

et al. 2017

J Tissue Eng Regen Med

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“…In the study of Aramwit et al, a sericin-based therapeutic cream formulation improved healing by promoting collagen production and rapid re-epithelialization in rat skin wounds (Aramwit et al, 2009(Aramwit et al, , 2013. Both twodimensional (films) and three-dimensional (scaffolds) sericin matrices, obtained using different blending methods, have been reported for skin tissue repair (Nayak et al, 2012;Lamboni et al, 2015;Karahaliloglu et al, 2017). Therefore, a sericin/CaP biomaterial could significantly accelerate and improves wound healing and soft tissue replacement.…”

Section: Other Applicationsmentioning

confidence: 99%

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

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Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.

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“…Alginate dressings are produced from the sodium and calcium salts comprising mannuronic and guluronic acid units [201,202], e.g., Sorbsan TM , Kaltostat TM and Algisite TM [200,203]. c. Bioactive wound dressings, which are known for their biocompatibility, biodegradability and nontoxic nature, are the last type of the modern wound dressings [204] and are derived generally from the natural tissues or artificial sources which play the serious role in healing process such as collagen [205], hyaluronic acid [206], chitosan [207,208], alginate and elastin. These materials are used alone or in combination depending on the nature and type of wound.…”

Section: Acellular Porcine or Xe-derma Scaffoldmentioning

confidence: 99%

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Bakhshayesh

Annabi

Khalilov

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

183

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The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries. Substitutes made from skin can harbour the latent viruses, and artificial skin grafts can heal with the extensive scarring, failing to regenerate structures such as glands, nerves and hair follicles. New and practical skin scaffold materials remain to be developed. The current article describes the important information about wound healing scaffolds. The scaffold types which were used in these fields were classified according to the accepted guideline of the biological medicine. Moreover, the present article gave the brief overview on the fundamentals of the tissue engineering, biodegradable polymer properties and their application in skin wound healing. Also, the present review discusses the type of the tissue engineered skin substitutes and modern wound dressings which promote the wound healing.

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Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material

Cited by 81 publications

References 46 publications

Functionalized PVA –silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling

Functionalized PVA –silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

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