Antibacterial Au nanostructured surfaces

Wu, Songmei; Zuber, Flavia; Brugger, Juergen; Maniura‐Weber, Katharina; Ren, Qun

doi:10.1039/c5nr06157a

Cited by 100 publications

(84 citation statements)

References 25 publications

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“…needle or pillar length) is a factor in cell death [23]; however it is less important than might be expected. Wu et al [24] have experimentally analysed the interactions of bacteria with nanostructured gold surfaces. They proposed that as the height of nanofeatures on the surface decreased, the features became more like "dots", resulting in reduced deformation/stretching of the bacterial cell membrane and thus lower percentage cell death.…”

Section: Introductionmentioning

confidence: 99%

Studies of black silicon and black diamond as materials for antibacterial surfaces

et al. 2018

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'Black silicon' (bSi) samples with surfaces covered in nanoneedles of varying length, areal density and sharpness, have been fabricated using a plasma etching process. These nanostructures were then coated with a conformal uniform layer of diamond using hot filament chemical vapour deposition to produce 'black diamond' (bD) surfaces. The effectiveness of these bSi and bD surfaces in killing Gram-negative (E. coli) and Gram-positive (S. gordonii) bacteria was investigated by culturing the bacteria on the surfaces for a set time and then measuring the live-to-dead ratio. All the nanostructured surfaces killed E. coli at a significantly higher rate than the respective flat Si or diamond control samples. The length of the needles was found to be less important than their separation, i.e. areal density. This is consistent with a model for mechanical bacteria death based on the stretching and disruption of the cell membrane, enhanced by the cells motility on the surfaces. In contrast, S. gordonii were unaffected by the nanostructured surfaces, possibly due to their smaller size, thicker cell membrane and/or their lack of motility.

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Section: Introductionmentioning

confidence: 99%

Studies of black silicon and black diamond as materials for antibacterial surfaces

et al. 2018

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“…Lastly, Wu et al 66 recently reported the antibacterial activity of sparsely ordered nanopillars, nanorings, and nanonuggets, each formed via the electrodeposition of gold onto nanoporous templates, towards methicillin-resistant S. aureus (MRSA) cells. Here, the authors reported >99% cell inactivity aer 2 hours of incubation for all surface structures investigated.…”

Section: Concentrationsmentioning

confidence: 99%

Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

et al. 2019

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The incorporation of high-aspect-ratio nanostructures across surfaces has been widely reported to impart antibacterial characteristics to a substratum. This occurs because the presence of such nanostructures can induce the mechanical rupture of attaching bacteria, causing cell death. As such, the development of highefficacy antibacterial nano-architectures fabricated on a variety of biologically relevant materials is critical to the wider acceptance of this technology. In this study, we report the antibacterial behavior of a series of substrata containing multi-directional electrodeposited gold (Au) nanospikes, as both a function of deposition time and precursor concentration. Firstly, the bactericidal efficacy of substrata containing Au nanospikes was assessed as a function of deposition time to elucidate the nanopattern that exhibited the greatest degree of biocidal activity. Here, it was established that multi-directional nanospikes with an average height of $302 nm AE 57 nm (formed after a deposition time of 540 s) exhibited the greatest level of biocidal activity, with $88% AE 8% of the bacterial cells being inactivated. The deposition time was then kept constant, while the concentration of the HAuCl 4 and Pb(CH 3 COO) 2 precursor materials (used for the formation of the Au nanospikes) was varied, resulting in differing nanospike architectures.Altering the Pb(CH 3 COO) 2 precursor concentration produced multi-directional nanostructures with a wider distribution of heights, which increased the average antibacterial efficacy against both Gramnegative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacteria. Importantly, the in situ electrochemical fabrication method used in this work is robust and straightforward, and is able to produce highly reproducible antibacterial surfaces. The results of this research will assist in the wider utilization of mechano-responsive nano-architectures for antimicrobial surface technologies.

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“…The microbicide properties of the nanostructures on the surfaces of black silicon, TiO 2 , polymer, and gold have been demonstrated. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] These surfaces with nanopatterns were generally prepared by a top-down approach on specific materials. Their application will be limited by the material of the substrates and its sophisticated and expensive approach.…”

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confidence: 99%

ZnO Nanopillar Coated Surfaces with Substrate‐Dependent Superbactericidal Property

Yuan

et al. 2018

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ZnO nanopillars coated on various surfaces are able to kill adhered bacteria and fungi due to their physical structure through a rupturing mechanism. Remarkably, zinc foil and galvanized steel surfaces with ZnO nanopillar coatings demonstrate an excellent remote bacteria-killing property. Their bacterial killing efficacy is several orders higher than ZnO nanopillars coated on other surfaces as well as ZnO nanoparticles themselves. Mechanistic study shows that the nanostructure surface kills adhered microbial cells by rupturing the cell wall, while superoxide ( O ) released from the ZnO coating with electrons donated from zinc via the Zn/ZnO interface rather than photoirritation is responsible for the superior remote killing. The results of this study represent a novel mechanism of surface disinfection and its application in water disinfection is also demonstrated.

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Antibacterial Au nanostructured surfaces

Cited by 100 publications

References 25 publications

Studies of black silicon and black diamond as materials for antibacterial surfaces

Studies of black silicon and black diamond as materials for antibacterial surfaces

Multi-directional electrodeposited gold nanospikes for antibacterial surface applications

ZnO Nanopillar Coated Surfaces with Substrate‐Dependent Superbactericidal Property

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