Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii

Fernandes-Negreiros, Marília Medeiros; Machado, Raynara Iusk Araújo; Bezerra, Fabiana Lima; Melo, Maria Celeste Nunes de; Alves, Monique Gabriela Chagas Faustino; Filgueira, Luciana Guimarães Alves; Morgano, Marcelo Antônio; Trindade, Edvaldo S.; Costa, Leandro Silva; Rocha, Hugo Alexandre Oliveira

doi:10.3390/nano8010006

Cited by 21 publications

(15 citation statements)

References 29 publications

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“…First, fucoidan was mixed with silver nitrate (AgNO 3 ) solution to form AgNPs. Fucoidan was used as capping agents as well as reducing agents for the formation of stable AgNPs [ 43 ]. Then, chitosan was added to the fucoidan-coated AgNPs to form stable AgNPs coated with chitosan–fucoidan polyelectrolyte complexes.…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

et al. 2018

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Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis of AgNPs was developed using seaweed polysaccharide fucoidan. The AgNPs were further coated with chitosan to form an electrolyte complex on the surface. The developed chitosan–fucoidan complex-coated AgNPs were characterized using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). FT-IR results suggested strong polyelectrolyte complexation between fucoidan and chitosan. The developed chitosan–fucoidan complex-coated AgNPs significantly inhibited microbial growth. Moreover, the AgNPs showed efficient anticancer activity in human cervical cancer cells (HeLa). This study demonstrated that chitosan–fucoidan complex-coated AgNPs hold high potential for food and cosmeceutical applications.

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Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

et al. 2018

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“…The various fractions may contain carbohydrates with different level of negative ions due to their sulfate groups. Most of the fractions showed bactericidal effects, which might be due to the presence of sulfated molecules, such as carrageenans [21], fucans [22], and laminarin [23] in different fractions.…”

Section: Discussionmentioning

confidence: 99%

The Antibacterial and Immunomodulatory Effects of Carbohydrate Fractions of the Seaweed Gracilaria persica

Khosravi

Gharibi

Kaviani

et al. 2018

JoMMID

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INTRODUCTION Algae contain diverse photosynthetic organisms that grow in aquatic environments. According to their morphology and chemical composition, marine macroalgae or seaweeds are classified into green algae (Chlorophyta), brown algae (Phaeophyta), and red algae (Rhodophyta) [1]. They have various bioactive organic and inorganic components with beneficial applications, such as feeding and health protection of humans and animals [2, 3]. Due to the emergence of antibiotic-resistant strains of bacteria, the medicinal plants might play an alternative role in the treatment of infectious diseases. The biological and pharmacological evaluation of seaweeds has led to discovering several natural or semi-synthetic drugs in recent years [4]. In response to harsh environmental conditions, algae produce various secondary metabolites [3, 5] that have bactericidal effects against some of the Grampositive and Gram-negative bacteria [6]. In addition, brown, red, and green seaweed extracts have been reported to have antioxidant, antiviral [7], antifungal [8], cytotoxic [9], and larvicidal properties [10]. The anti-inflammatory compounds of the seaweeds can be also used for medicinal applications [11]. The Gracilaria species grow in the tropical regions throughout the world. These Algae produce sulfated polysaccharides. The polysaccharide backbone of

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“…35,36 Similar to the use of xylan employed in this work, in other studies, the use of polysaccharides with reducing agents to synthesize silver nanoparticles has already been described. 27,28,37 Determination of the Composition of NX…”

Section: Synthesis Of Silver Nanoparticles With Xylan (Nano Xylan)mentioning

confidence: 99%

“…Also, the antitumor, immunomodulatory and antibacterial activities of the sPS of the seaweed Dictyota mertensii had intensified. 28 In both cases, they composed the structure of silver nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

<p>Synthesis of Silver Nanoparticle Employing Corn Cob Xylan as a Reducing Agent with Anti-<em>Trypanosoma cruzi</em> Activity</p>

Pinto¹,

Viana²,

Moreno³

et al. 2020

IJN

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Background: Chagas disease, also known as American Trypanosomiasis, is caused by the protozoan Trypanosoma cruzi. It is occurring in Americas, including USA and Canada, and Europe and its current treatment involves the use of two drugs as follows: benznidazole (BNZ) and nifurtimox, which present high toxicity and low efficacy during the chronic phase of the disease, thus promoting the search for more effective therapeutic alternatives. Amongst them xylan, a bioactive polysaccharide, extracted from corn cob. Methods: Ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy (FITR), Raman spectroscopy, energy-dispersive X-ray spectroscopy (EDS), scanning electron microscopy, atomic force microscopy, plasma optical emission spectroscopy (ICP-OES), dynamic light scattering (DLS) have been used to characterize the silver-xylan nanoparticles (NX). Their cytotoxicity was evaluated with 3-bromo(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) test. MTT and flow cytometry were used to ascertain the anti-Trypanosoma cruzi activity. Results: UV-Vis spectroscopy gave plasmon resonance ranging between 400 and 450 nm while FITC and Raman spectroscopy proved nano interface functionalized with xylan. ICP-OES data showed NX with xylan (81%) and silver (19%). EDS showed NX consisting of carbon (59.4%), oxygen (26.2%) and silver (4.8%) main elements. Spherical NX of 55 nm average size has been depicted with SEM and AFM, while DLS showed 102 ± 1.7 nm NX. The NX displayed negligible cytotoxicity (2000 µg/mL). NX (100 µg/mL) was more effective, regardless of experiment time, in affecting the ability of parasites to reduce MTT than BZN (100 µg/mL). In addition, NX (100 µg/mL) induced death of 95% of parasites by necrosis. Conclusion: This is the first time silver nanoparticles are presented as an anti-Trypanosoma cruzi agent and the data point to the potential application of NX to new preclinical studies in vitro and in vivo.

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Antibacterial, Antiproliferative, and Immunomodulatory Activity of Silver Nanoparticles Synthesized with Fucans from the Alga Dictyota mertensii

Cited by 21 publications

References 29 publications

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

The Antibacterial and Immunomodulatory Effects of Carbohydrate Fractions of the Seaweed Gracilaria persica

<p>Synthesis of Silver Nanoparticle Employing Corn Cob Xylan as a Reducing Agent with Anti-<em>Trypanosoma cruzi</em> Activity</p>

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