Antibacterial, antioxidant and cytotoxic activities of the stem bark of Archidendron jiringa (Jack) I.C. Nielsen

Abstract

Archidendron jiringa (Jack) I.C. Nielsen plant, locally known as jengkol, is a species belongs to Archidendron genus of the Fabaceae family. This plant is a potential source of biologically active secondary metabolites, which are useful for various purposes, such as to destroy bacteria and fungi, to treat cancer, and as antioxidant agent. In this study, extract of A. jiringa stem bark was fractionated and subsequently tested for antibacterial, cytotoxic and antioxidant activity. Extraction was carried out using maceration and fractionation of the extract was conducted using both vacuum liquid and column chromatography techniques to obtain three fractions. The biological activity of the bulk extract and fractions were then evaluated using disc diffusion method, revealing that the sample with the highest activity against Bacillus subtilis and Escherichia coli is the ethyl acetate extract, while no inhibitory effect on both bacteria was observed for some ethyl acetate fractions tested. The screening tests indicate that the bulk extract and all fractions exhibit promising toxicity, with the LC50 values in the range of 227–837 ppm. In addition, good antioxidant activities, with the IC50 values in the range of 0.7–7.2 ppm, are displayed by bulk extract and the fractions.

Male Magelang Duck’s Performance on Grower Period Fed by Probiotics Bacillus amiloliquifaciens And Jengkol Peel Extract

“…Phytobiotics can be contained from flowers, fruits, roots, leaves, and fruit peels [10]. Jengkol peel has high antioxidants and can be called as phytobiotics [11]. The combination of probiotics and phytobiotics is expected to improve the growth performance of Magelang ducks.…”