Antibacterial, anti-inflammatory and mutagenic effects of some medicinal plants used in South Africa for the treatment of wounds and retained placenta in livestock

Luseba, Dibungi; Elgorashi, E.E.; Ntloedibe, D.T.; Staden, J. Van

doi:10.1016/j.sajb.2007.03.003

Cited by 122 publications

(87 citation statements)

References 21 publications

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“…If the plant is crushed and left overnight in water, the resultant mucilage from the leaves becomes a useful substitute for soap and shampoo (Van Wyk and Gericke, 2000). In terms of medicinal purposes, DE can be used for antibacterial (Luseba et al, 2007) and ethnoveterinary medicines (Van Der Merwe et al, 2001). Parts of the plant have been used to treat diseases in the rural areas of the Vhembe District, South Africa.…”

Section: Introductionmentioning

confidence: 99%

Coagulation efficiency of <i>Dicerocaryum eriocarpum</i> (DE) plant

Odiyo¹,

Bassey²,

Ochieng³

et al. 2017

WSA

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A study was conducted to investigate coagulation efficiency of the plant Dicerocaryum eriocarpum (DE) in the removal of turbidity from raw water. Widespread poor land use practices contribute to high turbidity in river water, making turbidity management or removal critical, particularly before the water is used for drinking or subjected to chemical treatment. In this study, mucilage from DE was extracted with deionized water and different chloride solutions. A coagulation efficiency of 99% using modified mucilage coagulant was achieved. The modified mucilage of potassium crude extract and sodium crude extract displayed higher coagulation efficiencies than unmodified mucilage of deionized water crude extract. An increase in coagulant dosage and initial turbidity influenced the coagulation efficiency of DE coagulant. A large reduction in turbidity levels of the treated water samples resulted in an improvement in water quality.

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Section: Introductionmentioning

confidence: 99%

Coagulation efficiency of <i>Dicerocaryum eriocarpum</i> (DE) plant

Odiyo¹,

Bassey²,

Ochieng³

et al. 2017

WSA

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“…Methanolic extracts of another Asteraceae species, Schkuhria pinnata (Lam.) used in traditional medicine to treat eye infections, Pneumonia and diarrhea in South Africa was not mutagenic in the Salmonella microsome assay against Salmonella typhimurium tester strain TA98 but showed antibacterial activity (Luseba et al, 2007). The mixture of CP (1.25 mg mL -1 ) with each concentration of extract of Dicoma anomala separately was cytotoxic and genotoxic to the root tip meristem cells.…”

Section: Discussionmentioning

confidence: 94%

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Asita¹,

Heisi²,

Tjale³

2015

ENRR

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Methanolic extracts (mg mL -1 ) of Dicoma anomala (0.0625, 0.125, 0.25), Chenopodium album (0.078, 0.156, 0.313), used in traditional medicine in Lesotho, and Camellia sinensis (0.1094, 0.2085, 0.44) were assessed for cytotoxicity, genotoxicity and modulation of Cyclophosphamide (CP 1.25 mg mL -1 ) -and EMS (0.25 mg mL -1 )-induced genotoxicity using the Allium cepa assay following 24 hours treatment. Cytotoxicity was measured by the mitotic index (MI). Genotoxicity (GT) was expressed as the number of aberrant mitotic cells per 100 mitotic cells. The MI and GT of test groups (triplicates), were compared with the negative (water) control group using t-test. Modulatory effect (ME) was calculated as, ME(%) = (1-(A-B)/(A-C) × 100) -1. A positive ME indicated an increase (synergism or potentiation) while a negative ME indicated a reduction (anti-genotoxicity) of mutagen-induced genotoxicity. The concentrations of D. anomala extract were cytotoxic and genotoxic. Mixtures of CP or EMS with the lower concentrations of D. anomala extract were more genotoxic than CP (250.50% increase) or EMS (149.74 and 157.37 % increase) or extracts alone. Only 0.313 mg mL -1 of C. album extract was cytotoxic but none of the three concentrations was genotoxic. Mixtures of CP with extracts of C.album were cytotoxic. CP-induced genotoxicity was reduced (55.18, 68.36, 57.40 %) and EMS-induced genotoxicity was also reduced by low concentrations (50.72, 61.13 %) of C.album extract. However, 0.313 mg mL -1 C. album extract increased (236.75%) EMS-induced genotoxicity. C. sinensis extracts and their mixtures with CP were not cytotoxic or genotoxic. CP-induced genotoxicity was reduced (63.61, 66.62, 78.64 %) but EMS-induced genotoxicity was increased (124.97, 4.48, 110.52 %) by C. sinensis extract.

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“…to treat diarrhea, heavy menstruation, nose bleeding, headache, stomach-ache, parasitic worms, sores and skin problems (Takawira-Nyenya, 2005). Pharmacological studies on P. angolensis revealed antibacterial activity of seeds (Steenkamp et al, 2004), stem bark, roots and leaf extracts (Luseba et al, 2007;Mulaudzi et al, 2011;Samie et al, 2009) and antifungal activity of leaf and bark extracts (Mulaudzi et al, 2011). The latter also showed HIV-1 reverse transcriptase inhibitory activity (Mulaudzi et al, 2011) as well as anthelmintic effects (McGaw et al, 2007;Molgaard et al, 2001).…”

Section: Pterocarpus Angolensismentioning

confidence: 98%

Woody species from the Mozambican Miombo woodlands: A review on their ethnomedicinal uses and pharmacological potential

Moura¹,

Duvane²,

Silva³

et al. 2018

J. Med. Plants Res.

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Miombo woodlands cover about two thirds of Mozambique national territory. They provide a wide collection of goods and services to the formal and informal economies. A review on the traditional uses of 15 Miombo tree species in human and animal health, as well as the status of research towards the identification of bioactive compounds is presented. Among the 15 species selected, 12 have been screened for their biological activity and/or pharmacological properties and/or toxicity. The information gathered in this work is a key to further exploit potential new uses and future opportunities for research and valorization of the selected species.

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Antibacterial, anti-inflammatory and mutagenic effects of some medicinal plants used in South Africa for the treatment of wounds and retained placenta in livestock

Cited by 122 publications

References 21 publications

Coagulation efficiency of <i>Dicerocaryum eriocarpum</i> (DE) plant

Coagulation efficiency of <i>Dicerocaryum eriocarpum</i> (DE) plant

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Woody species from the Mozambican Miombo woodlands: A review on their ethnomedicinal uses and pharmacological potential

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