Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains

Pereira, Raimundo Luiz Silva; Campina, Fábia F.; Costa, Maria do Socorro; Cruz, Rafael Pereira da; Freitas, Thiago Sampaio de; Santos, Antônia Thassya Lucas dos; Cruz, Beatriz Gonçalves; Júnior, Diniz Maciel de Sena; Lima, Igor Kleber Campos; Xavier, Maria Regivânia; Teixeira, Alexandre Magno Rodrigues; Menezes, Irwin Rose Alencar de; Quintans‐Júnior, Lucindo José; Araújo, Adriano Antunes de Souza; Coutinho, Henrique Douglas Melo

doi:10.1016/j.micpath.2021.104928

Cited by 9 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the magnetic properties of β-CD/Fe 3 O 4 NPs enabling them to break down the cellular barrier and infiltrate the bacterial cell, it was hypothesized that the significant antimicrobial effects might be attributed to the presence of biomolecules coated on the surface that originated from β-CD. These biomolecules are believed to play a crucial role in antimicrobial activity by disrupting the bacterial cell mechanism …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications

Almutairi,

Al-Rasheed,

Alaqil

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Iron oxide nanoparticles (Fe 3 O 4 NPs) are a fascinating field of study due to their wide range of practical applications in environmental and medical contexts. This study presents a straightforward, environmentally friendly method for producing Fe 3 O 4 NPs utilizing β-cyclodextrin (β-CD) as a reducing and capping agent. This approach results in the rapid and effective eco-friendly synthesis of β-CD/Fe 3 O 4 NPs. The properties and characteristics of β-CD/Fe 3 O 4 NPs were investigated using various methods, including ultraviolet−visible (UV/vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetry analysis (TGA), and vibrating-sample magnetometry (VSM). The absorption of β-CD/Fe 3 O 4 NPs caused a distinct peak at 349 nm, as evidenced by the results of UV/vis studies. This peak was attributed to the absorption of surface plasmon resonance. The crystalline nature of β-CD/Fe 3 O 4 NPs was confirmed through XRD analysis. The SEM and TEM analyses have verified the geometry and structural characteristics of β-CD/Fe 3 O 4 NPs. The β-CD/Fe 3 O 4 NPs exhibited remarkable effectiveness in the decomposing efficiency (%) of methylene blue (MB) dye with 52.2, 94.1, and 100% for 0.2, 0.4, and 0.6 g β-CD/ Fe 3 O 4 NPs, respectively. In addition, the highest efficiency in hunting radicals was observed (347.2 ± 8.2 mg/g) at 100 mg/mL β-CD/Fe 3 O 4 NPs; the combination of β-CD/Fe 3 O 4 NPs exhibited remarkable effectiveness in inhibiting the growth of some bacteria that cause infections. The capabilities of β-CD/Fe 3 O 4 NPs for various applications showed that these materials could be used in photocatalytic, antioxidants, and antibacterial. Additionally, the eco-friendly synthesis of these materials makes them a promising option for the remediation of harmful pollutants and microbes.

show abstract

Section: Resultsmentioning

confidence: 99%

“…These biomolecules are believed to play a crucial role in antimicrobial activity by disrupting the bacterial cell mechanism. 65 …”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications

Almutairi,

Al-Rasheed,

Alaqil

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Sill with regard to effects of monoterpenes against resistant S. aureus strains, Freitas et al [ 43 ] also stated that α -pinene potentiated the effect of tetracycline against the S. aureus IS-58 strain, while studies with E. coli conducted by Pereira et al [ 70 ] showed that the complex (+)- β -citronellol ( β CT)/ β -cyclodextrin ( β -CD) in combination with gentamicin showed a synergistic effect against E. coli .…”

Section: Resultsmentioning

confidence: 99%

Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

Leite-Sampaio

Gondim

Martins

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

The increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the combat of infections caused by multidrug-resistant (MDR) bacteria. Considering the verification that terpenes are promising antibacterial compounds, the present research aimed to evaluate the antibacterial and antibiotic-modulating activity of (+)-α-pinene and (-)-borneol against MDR bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compounds and antibiotics and further evaluate the intrinsic and associated antibiotic activity. These analyses revealed that (+)-α-pinene showed significant antibacterial activity only against E. coli ( MIC = 512 μ g . m L − 1 ), while no significant inhibition of S. aureus and P. aeruginosa growth was observed ( MIC ≥ 1024 μ g m L − 1 ). However, when combined with antibiotics, this compound induced a significant improvement in the activity of conventional antibiotics, as observed for ciprofloxacin, amikacin, and gentamicin against Staphylococcus aureus, as well as for amikacin and gentamicin against Escherichia coli, and amikacin against Pseudomonas aeruginosa. On the other hand, (-)-borneol was found to inhibit the growth of E. coli and enhance the antibiotic activity of ciprofloxacin and gentamicin against S. aureus. The present findings indicate that (+)-α-pinene and (-)-borneol are phytocompounds with the potential to be used in the combat of antibacterial resistance.

show abstract

“…This promising activity of Ferula compared to other oils may be attributed to the high content of the oxygenated monoterpenes, especially linalool, citronellol, allo-ocimene, and 4-terpineol. These compounds were reported to have a relevant bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria [29][30][31][32][33]. Data are presented as means ± S.D.…”

Section: Biological Activities 231 Antibacterial Activitymentioning

confidence: 99%

Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity

Jamalova

Gad

Akramov

et al. 2021

Plants

View full text Add to dashboard Cite

The chemical composition of the essential oils obtained from the aerial parts of four Apiaceae species, namely Elaeosticta allioides (EA), E. polycarpa (EP), Ferula clematidifolia (FC), and Hyalolaena intermedia (HI), were determined using gas chromatography. Altogether, 100 volatile metabolites representing 78.97, 81.03, 85.78, and 84.49% of the total components present in EA, EP, FC, and HI oils, respectively, were reported. allo-Ocimene (14.55%) was the major component in FC, followed by D-limonene (9.42%). However, in EA, germacrene D (16.09%) was present in a high amount, while heptanal (36.89%) was the predominant compound in HI. The gas chromatographic data were subjected to principal component analysis (PCA) to explore the correlations between these species. Fortunately, the PCA score plot could differentiate between the species and correlate Ferula to Elaeosticta species. Additionally, the antioxidant activity was evaluated in vitro using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and the ferric reducing power (FRAP) assays. In addition, the antimicrobial activity using the agar diffusion method was assessed, and the minimum inhibitory concentrations (MICs) were determined. Furthermore, the cell viability MTT assay was performed to evaluate the cytotoxicity of the essential oils against hepatic (HepG-2) and cervical (HeLa) cancer cell lines. In the DPPH assay, FC exhibited the maximum activity against all the antioxidant assays with IC50 values of 19.8 and 23.0 μg/mL for the DPPH and ABTS assays, respectively. Ferula showed superior antimicrobial and cytotoxic activities as well. Finally, a partial least square regression model was constructed to predict the antioxidant capacity by utilizing the metabolite profiling data. The model showed excellent predictive ability by applying the ABTS assay.

show abstract

Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains

Cited by 9 publications

References 38 publications

Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications

Green Synthesis of Magnetic Supramolecules β-Cyclodextrin/Iron Oxide Nanoparticles for Photocatalytic and Antibacterial Applications

Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

Discrimination of the Essential Oils Obtained from Four Apiaceae Species Using Multivariate Analysis Based on the Chemical Compositions and Their Biological Activity

Contact Info

Product

Resources

About