Antibacterial and hemostatic hydrogel via nanocomposite from cellulose nanofibers

Li, Rui; Dai, Lin; Si, Chuanling; Zeng, Zhaogang

doi:10.1016/j.carbpol.2018.04.085

Cited by 157 publications

(66 citation statements)

References 41 publications

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“…In vivo wound healing testing was done on Kunming mice, and CNF/G/Ag showed a survival rate of 83%. However, the blood clotting tests showed good haemostatic properties that slightly decreased with the increase in Ag nanoparticles (Liu et al ., ).…”

Section: Biocompatibility Of Bacterial Cellulosementioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

378

269

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Summary Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical–chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC‐based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.

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Section: Biocompatibility Of Bacterial Cellulosementioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

378

269

View full text Add to dashboard Cite

show abstract

“…Good clinical wound management is very important to combat various complications that may occur during the healing process. The management of wounds includes the control of microbial infections, cleaning the wound environment to make it free from foreign substances and the selection of a suitable wound dressing [ 2 , 3 , 4 , 5 ]. An ideal wound dressing should have several important features such as high porosity, high water-absorbing capacity, good water vapor transmission rate, non-toxicity, excellent gaseous permeation and ability to maintain a moist environment to speed up the wound healing process [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…According to the previous reports, the hydrogels with interconnected porous structure can quickly absorb a large amount of blood, causing the absorption of platelet and blood cells, thereby inducing blood clotting. [21] Because hydrogels with different concentrations of AM NSs had similar porosity, their clotting abilities were almost the same.…”

Section: In Vitro Blood Testmentioning

confidence: 99%

Construction of Chitosan‐Based Hydrogel Incorporated with Antimonene Nanosheets for Rapid Capture and Elimination of Bacteria

Liu

Xiao

Cao

et al. 2020

Adv Funct Materials

128

100

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To elaborately construct a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for treating bacterial wound infections. In this work, a composite hydrogel (CS/AM NSs hydrogel) with outstanding antibacterial ability is constructed by incorporating antimonene nanosheets (AM NSs) with extraordinary photothermal properties into the network structure of chitosan (CS). When cultured with bacteria, the CS/AM NSs hydrogel can gather bacteria on the surface through the interaction of CS with the bacterial cell membrane. Subsequently, the intrinsic bactericidal property of CS will kill some of the bacteria. After the introduction of near‐infrared laser, the AM NSs effectively convert light energy into localized heat to eliminate residual bacteria. By virtue of the synergistic action between the capture effect of CS and the photothermal effect of AM NSs, the CS/AM NSs hydrogel shows predominant antibacterial behavior against Escherichia coli and Staphylococcus aureus. In vitro assay and in vivo tests of infected full‐thickness defect wound healing confirm the satisfactory biocompatibility and antibacterial ability. Overall, this work reveals that the CS/AM NSs hydrogel holds great potential as a broad‐spectrum antibacterial wound dressing for treating bacteria‐infected wounds. Additionally, this is the first report of the application of AM NSs in the field of antibacterial treatment.

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Antibacterial and hemostatic hydrogel via nanocomposite from cellulose nanofibers

Cited by 157 publications

References 41 publications

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Construction of Chitosan‐Based Hydrogel Incorporated with Antimonene Nanosheets for Rapid Capture and Elimination of Bacteria

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