Antibacterial and Degradable Thioimidazolium Poly(ionic liquid)

Smith, Christene A.; Cataldo, Vincenzo Alessandro; Dimke, Thomas; Stephan, Ina; Guterman, Ryan

doi:10.1021/acssuschemeng.0c02666

Cited by 19 publications

(16 citation statements)

References 37 publications

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“…Important attention is also given to poly-ionic liquids (PILs), which can be designated to achieve amphiphilicity, thereby allowing the polymer’s rapid and efficient transfer through the lipid bilayer of the bacterial membrane [ 242 ]. It has been documented that PILs with high cation density and long alkyl chains have superior antimicrobial efficacy to their small-molecule counterparts [ 243 ].…”

Section: Future Promising Strategies In Cre Treatmentmentioning

confidence: 99%

“…It has been documented that PILs with high cation density and long alkyl chains have superior antimicrobial efficacy to their small-molecule counterparts [ 243 ]. However, the use of PILs is currently limited by bioaccumulation in the environment, and studies are focused on identifying compounds with optimal biodegradability [ 242 ].…”

Section: Future Promising Strategies In Cre Treatmentmentioning

confidence: 99%

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Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

et al. 2021

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Carbapenem-resistant Enterobacterales (CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment.

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Section: Future Promising Strategies In Cre Treatmentmentioning

confidence: 99%

Section: Future Promising Strategies In Cre Treatmentmentioning

confidence: 99%

Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

et al. 2021

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“…However, research regarding more broad biocidal ionic liquids have found that activity is correlated with higher molecular weights in general, not necessarily just alkyl chains [31].…”

Section: Ionic Systems As Antiseptic and Disinfectantsmentioning

confidence: 99%

Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review

Faísca¹,

Filipe²,

Petrovski³

et al. 2021

Surfaces

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Antiseptics and disinfectants are extensively used for a variety of topical and hard-surface applications. A wide variety of biocides as active chemical agents is found in these products, including alcohols, phenols, iodine, and chlorine. Many of these active agents demonstrate broad-spectrum antimicrobial activity; however, the mode of action of these agents is not well-documented. This review is focused on several examples of ionic systems based on ionic surfactants and ionic liquids as well as nanomaterials and nanoparticles acting as antiseptics and disinfectants for surfaces. It is important to note that many of these biocides may be used singly or in combination in a variety of products, which vary considerably in activity against microorganisms. Antimicrobial activity can be influenced by several factors such as formulation effects, presence of an organic load, synergy, temperature, dilution, and test method. The most promissory compounds based on ionic systems and nanomaterials published in mainly the last decade is chronologically reported in this review.

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“…Poly(ionic liquids) (PILs) consists of repeating units of polymer backbone and ionic liquid (IL) species [ 13 , 14 ]. Recently, various imidazolium PILs have been synthesized and exhibited high sterilization rates against E. coli and S. aureus , as well as multi-drug resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) [ 15 , 16 , 17 , 18 , 19 , 20 ]. The imidazolium PILs can serve as the antibacterial agents, and they are gaining more and more attention.…”

Section: Introductionmentioning

confidence: 99%

“…Most reported imidazolium PILs contain chloride, bromide, iodide, zinc, and copperas as counter ions, which could pose a hazard to normal cells [ 15 , 16 , 18 , 19 , 24 ]. Furthermore, few papers reported antibacterial hydrogels with PILs.…”

Section: Introductionmentioning

confidence: 99%

Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels

Zhao

Sheng

Zhou

2022

Gels

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Traditional antibacterial hydrogels have a broad-spectrum bactericidal effect and are widely used as wound dressings. However, the biological toxicity and drug resistance of these antibacterial hydrogels cannot meet the requirements of long-term clinical application. Imidazolium poly(ionic liquids) (PILs) are polymeric antibacterial agents exhibiting strong antibacterial properties, as they contain a strong positive charge. In this study, two imidazolium PILs, namely poly(N-butylimidazolium propiolic acid sodium) (PBP) and poly(N-(3,6-dioxaoctane) imidazolium propiolic acid sodium) (PDP), as high efficiency antibacterial agents, were synthesized by polycondensation reaction. Then, the PILs were compounded with polyethylene glycol (PEG) by a thiol-yne click reaction to prepare injectable antibacterial hydrogels. An in vitro assay showed that the injectable antibacterial hydrogels could not only quickly kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), but also had low toxicity for human skin fibroblasts cells (HSFs) and human umbilical vein endothelial cells (HUVECs), respectively. Additionally, the lipopolysaccharide (LPS) inflammation model revealed that the injectable antibacterial hydrogels also had anti-inflammatory effects, which would be advantageous to accelerate wound healing.

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Antibacterial and Degradable Thioimidazolium Poly(ionic liquid)

Cited by 19 publications

References 37 publications

Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surface Applications: A Review

Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels

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