Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface

Leśniak-Ziółkowska, Katarzyna; Śmiga-Matuszowicz, Monika; Blacha–Grzechnik, Agata; Student, Sebastian; Brzychczy-Włoch, Monika; Krok-Borkowicz, Małgorzata; Pamuła, Elżbieta; Simka, Wojciech; Kazek-Kęsik, Alicja

doi:10.1016/j.bioactmat.2020.04.020

Cited by 20 publications

(20 citation statements)

References 35 publications

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“…302 However, the clinical treatments not only have a failure rate of as high as 30%, but also lead to inevitable tissue disfigurements, drug resistance, and organ toxicity. 303,304 Although nanoparticles or hydrogels can improve the therapeutic efficiency of antibiotics and reduce the dosage, such intervention methods become helpless in the face of superbugs. 305,306 In recent years, as a bright direction of SACs, PTT-assisted enzymatic treatment has been established to have excellent therapeutic effect on tumors.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Engineering single-atom catalysts toward biomedical applications

Chang

Zhang

et al. 2022

Chem. Soc. Rev.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Engineering single-atom catalysts toward biomedical applications

Chang

Zhang

et al. 2022

Chem. Soc. Rev.

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“…Porous oxide layers can be treated using additional techniques, e.g., electrophoretic deposition, ion implantation, atomic layer deposition, or the widely-used dip coating process [ 146 ]. Then, the resulting functional hybrid coating is equipped with antibacterial properties to protect the surface against the adhesion of bacteria, the formation of biofilms, and in some cases, biologically-active substances are released from the coatings to treat bone-related infections [ 147 ]. Porous oxide layers might also be immersed in a solution containing biologically-active substances, e.g., in a solution of betamethasone sodium phosphate, which exhibits antimicrobial properties [ 148 ].…”

Section: Control Strategies For the Formation Of Clinically Important...mentioning

confidence: 99%

Recent Advances in the Control of Clinically Important Biofilms

Krukiewicz

Kazek-Kęsik

Brzychczy-Włoch

et al. 2022

IJMS

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Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several clinically important diseases. The inability to completely eradicate biofilms drastically increases the burden of disease on both the patient and the healthcare system. Therefore, it is crucial to develop innovative ways to tackle the growth and development of biofilms. This review focuses on dental- and implant-associated biofilm infections, their prevalence in humans, and potential therapeutic intervention strategies, including the recent advances in pharmacology and biomedical engineering. It lists current strategies used to control the formation of clinically important biofilms, including novel antibiotics and their carriers, antiseptics and disinfectants, small molecule anti-biofilm agents, surface treatment strategies, and nanostructure functionalization, as well as multifunctional coatings particularly suitable for providing antibacterial effects to the surface of implants, to treat either dental- or implant-related bacterial infections.

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“…Furthermore, antimicrobial agents can lead to environmental contamination and toxicity to the human body due to biocidal diffusion [23,24]. In contrast to low molecular weight compounds, antimicrobial polymers show better antimicrobial efficacy and lower residual toxicity due to higher stability and non-volatility, and thus having a long-term activity [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures

et al. 2022

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The antibacterial activity of different antibiotic and metal-free thin polymer coatings was investigated. The films comprised quaternary ammonium compounds (QAC) based on a vinyl benzyl chloride (VBC) building block. Two monomeric QAC of different alkyl chain lengths were prepared, and then polymerized by two different polymerization processes to apply them onto Ti surfaces. At first, the polymeric layer was generated directly on the surface by atom transfer radical polymerization (ATRP). For comparison purposes, in a classical route a copolymerization of the QAC-containing monomers with a metal adhesion mediating phosphonate (VBPOH) monomers was carried out and the Ti surfaces were coated via drop coating. The different coatings were characterized by X-ray photoelectron spectroscopy (XPS) illustrating a thickness in the nanomolecular range. The cytocompatibility in vitro was confirmed by both live/dead and WST-1 assay. The antimicrobial activity was evaluated by two different assays (CFU and BTG, resp.,), showing for both coating processes similar results to kill bacteria on contact. These antibacterial coatings present a simple method to protect metallic devices against microbial contamination.

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Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface

Cited by 20 publications

References 35 publications

Engineering single-atom catalysts toward biomedical applications

Engineering single-atom catalysts toward biomedical applications

Recent Advances in the Control of Clinically Important Biofilms

Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures

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